Bioanalytical Chemistry of Cytokines–a Review

Stenken, Julie A.; Poschenrieder, Andreas J.

doi:10.1016/j.aca.2014.10.009

Cited by 302Advanced Biosensing Techniques and ApplicationsAdvanced biosensing and bioanalysis techniquesAdvanced Proteomics Techniques and Applications

Bioanalytical Chemistry of Cytokines–a Review

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Stenken, Julie A., Poschenrieder, Andreas J.·2015·Analytica Chimica Acta

DOI 10.1016/j.aca.2014.10.009PMC PMC4717841

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Abstract

Cytokines are bioactive proteins produced by many different cells of the immune system. Due to their role in different inflammatory disease states and maintaining homeostasis, there is enormous clinical interest in the quantitation of cytokines. The typical standard methods for quantitation of cytokines are immunoassay-based techniques including enzyme-linked immusorbent assays (ELISA) and bead-based immunoassays read by either standard or modified flow cytometers. A review of recent developments in analytical methods for measurements of cytokine proteins is provided. This review briefly covers cytokine biology and the analysis challenges associated with measurement of these biomarker proteins for understanding both health and disease. New techniques applied to immunoassay-based assays are presented along with the uses of aptamers, electrochemistry, mass spectrometry, optical resonator-based methods. Methods used for elucidating the release of cytokines from single cells as well as in vivo collection methods are described.

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ELISA is the most widely used label-based immunoassay to quantify soluble protein in liquid biopsies such as serum and plasma.
“The most widely used label-based immunoassay to quantify soluble protein in liquid biopsies such as serum and plasma is the Enzyme-linked Immunosorbent Assay (ELISA) (3).”
From Tumor-Induced Inflammatory Cytokines and the Emerging Diagnostic Devices for Cancer Detection and Prognosis (2021) · cites this paper as [3]
Section 2.1 (page unavailable) says ELISA platforms are widely available and used to quantify cytokines, and Section 5 describes labeled detection antibodies in standard cytokine immunoassays. The review does not establish that ELISA is the most widely used label-based immunoassay for soluble proteins generally in serum and plasma; that ranking and broader scope go beyond its statement. (LLM, conf=0.82)
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In vitro selection of RNA molecules that bind specific ligands
Ellington, A. D., & Szostak, J. W. (1990) · Nature · doi:10.1038/346818a0 · Cited by 9,845 · see citing works
Light-Directed, Spatially Addressable Parallel Chemical Synthesis
Fodor, S. P. A., Read, J., Pirrung, M. C., Stryer, L., Lu, A. T., & Solas, D. W. (1991) · Science · doi:10.1126/science.1990438 · Cited by 2,697 · see citing works
Nanoparticle-Based Bio-Bar Codes for the Ultrasensitive Detection of Proteins
Nam, J., Thaxton, C. S., & Mirkin, C. A. (2003) · Science · doi:10.1126/science.1088755 · Cited by 2,391 · see citing works
Single-Cell Mass Cytometry of Differential Immune and Drug Responses Across a Human Hematopoietic Continuum
Bendall, S. C., Simonds, E. F., Qiu, P., Amir, E.-A. D., Krutzik, P. O., Finck, R., Bruggner, R. V., Melamed, R., Trejo, A., Ornatsky, O. I., et al. (2011) · Science · doi:10.1126/science.1198704 · Cited by 2,279 · see citing works
Sensitive optical biosensors for unlabeled targets: A review
Fan, X., White, I. M., Shopova, S. I., Zhu, H., Suter, J. D., & Sun, Y. (2008) · Analytica Chimica Acta · doi:10.1016/j.aca.2008.05.022 · Cited by 2,185 · see citing works
Electrogenerated Chemiluminescence and Its Biorelated Applications
Miao, W. (2008) · Chemical Reviews · doi:10.1021/cr068083a · Cited by 2,135 · see citing works
Proinflammatory Cytokines
Dinarello, C. A. (2000) · CHEST Journal · doi:10.1378/chest.118.2.503 · Cited by 2,047 · see citing works
Nanoparticle-Based Bio-Barcodes for the Ultrasensitive Detection of Proteins*
Nam, J., Thaxton, C. S., & Mirkin, C. A. (2020) · Spherical Nucleic Acids · doi:10.1201/9781003056713-94 · Cited by 2,038 · see citing works
Interferons, interferon‐like cytokines, and their receptors
Pestka, S., Krause, C. D., & Walter, M. R. (2004) · Immunological Reviews · doi:10.1111/j.0105-2896.2004.00204.x · Cited by 1,768 · see citing works
Cellular Actions of the Insulin-Like Growth Factor Binding Proteins
Firth, S. M., & Baxter, R. C. (2002) · Endocrine Reviews · doi:10.1210/er.2001-0033 · Cited by 1,754 · see citing works
Aptamer-Based Multiplexed Proteomic Technology for Biomarker Discovery
Gold, L., Ayers, D., Bertino, J., Bock, C., Bock, A., Brody, E. N., Carter, J., Dalby, A. B., Eaton, B. E., Fitzwater, T., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0015004 · Cited by 1,754 · see citing works
Protein detection using proximity-dependent DNA ligation assays
Fredriksson, S., Gullberg, M. T., Jarvius, J., Olsson, C., Pietras, K., Gustafsdottir, S., Östman, A., & Landegren, U. D. (2002) · Nature Biotechnology · doi:10.1038/nbt0502-473 · Cited by 1,511 · see citing works
Biomarkers in Heart Failure
D, E. B. M. (2008) · New England Journal of Medicine · doi:10.1056/nejmra0800239 · Cited by 1,252 · see citing works
Label-Free, Single-Molecule Detection with Optical Microcavities
Armani, A. M., Kulkarni, R. P., Fraser, S. E., Flagan, R. C., & Vahala, K. J. (2007) · Science · doi:10.1126/science.1145002 · Cited by 1,139 · see citing works
The cytokine handbook
Thomson, A. W. (1994) · Cited by 1,114 · see citing works
Historical insights into cytokines
Dinarello, C. A. (2007) · European Journal of Immunology · doi:10.1002/eji.200737772 · Cited by 926 · see citing works
Multiplexed particle-based flow cytometric assays
Vignali, D. A. A. (2000) · Journal of Immunological Methods · doi:10.1016/s0022-1759(00)00238-6 · Cited by 916 · see citing works
Handbook of Surface Plasmon Resonance
Kooyman, R. P. H., Corn, R. M., Wark, A. W., Lee, H. J., Gedig, E. T., Engbers, G. H. M., Walstrom, L., de Mol, N. J., Hall, D. R., Yager, P., et al. (2008) · Royal Society of Chemistry eBooks · doi:10.1039/9781847558220 · Cited by 843 · see citing works
Mass Spectrometric Quantitation of Peptides and Proteins Using Stable Isotope Standards and Capture by Anti-Peptide Antibodies (SISCAPA)
Anderson, N. L., Anderson, N. G., Haines, L. R., Hardie, D. B., Olafson, R. W., & Pearson, T. W. (2004) · Journal of Proteome Research · doi:10.1021/pr034086h · Cited by 806 · see citing works
The cytokine network
Balkwill, F. R., & Burke, F. (1989) · Immunology Today · doi:10.1016/0167-5699(89)90085-6 · Cited by 785 · see citing works
Soluble receptors for cytokines and growth factors: generation and biological function
Rose‐John, S., & Heinrich, P. C. (1994) · Biochemical Journal · doi:10.1042/bj3000281 · Cited by 784 · see citing works
Aptamer in Bioanalytical Applications
Iliuk, A. B., Hu, L., & Tao, W. A. (2011) · Analytical Chemistry · doi:10.1021/ac201057w · Cited by 764 · see citing works
Aptamers Generated from Cell-SELEX for Molecular Medicine: A Chemical Biology Approach
Fang, X., & Tan, W. (2009) · Accounts of Chemical Research · doi:10.1021/ar900101s · Cited by 748 · see citing works
Cytokine profiles as markers of disease severity in sepsis: a multiplex analysis
Bozza, F. A., Salluh, J. I., Japiassú, A. M., Soares, M., de Assis, E. F., Gomes, R. N., Bozza, M. T., Castro-Faria-Neto, H. C., & Bozza, P. T. (2007) · Critical Care · doi:10.1186/cc5783 · Cited by 740 · see citing works
Electrochemical Immunosensors for Detection of Cancer Protein Biomarkers
Chikkaveeraiah, B. V., Bhirde, A. A., Morgan, N. Y., Eden, H. S., & Chen, X. S. (2012) · ACS Nano · doi:10.1021/nn3023969 · Cited by 721 · see citing works
The rational development of molecularly imprinted polymer-based sensors for protein detection
Whitcombe, M. J., Chianella, I., Larcombe, L. D., Piletsky, S. A., Noble, J. E., Porter, R., & Horgan, A. M. (2010) · Chemical Society Reviews · doi:10.1039/c0cs00049c · Cited by 710 · see citing works
A unified view of propagating and localized surface plasmon resonance biosensors
Haes, A. J., & Duyne, R. P. V. (2004) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-004-2708-9 · Cited by 667 · see citing works
Multiplexed protein profiling on microarrays by rolling-circle amplification
Schweitzer, B. I., Roberts, S. J., Grimwade, B. G., Shao, W., Wang, M., Fu, Q., Shu, Q., Laroche, I., Zhou, Z., Tchernev, V. T., et al. (2002) · Nature Biotechnology · doi:10.1038/nbt0402-359 · Cited by 572 · see citing works
The fundamental flaws of immunoassays and potential solutions using tandem mass spectrometry
Hoofnagle, A. N., & Wener, M. H. (2009) · Journal of Immunological Methods · doi:10.1016/j.jim.2009.06.003 · Cited by 562 · see citing works
Electrochemiluminescence detection for development of immunoassays and DNA probe assays for clinical diagnostics
Blackburn, G. F., Shah, H. P., Kenten, J. H., Leland, J. K., Kamin, R. A., Link, J., Peterman, J., Powell, M. J., Shah, A., & Talley, D. B. (1991) · Clinical Chemistry · doi:10.1093/clinchem/37.9.1534 · Cited by 558 · see citing works
Measurement of biomarker proteins for point-of-care early detection and monitoring of cancer
Rusling, J. F., Kumar, C. V., Gutkind, J. S., & Patel, V. (2010) · The Analyst · doi:10.1039/c0an00204f · Cited by 555 · see citing works
Aptamer-Modified Gold Nanoparticles for Colorimetric Determination of Platelet-Derived Growth Factors and Their Receptors
Huang, C., Huang, Y., Cao, Z. C., Tan, W., & Chang, H. (2005) · Analytical Chemistry · doi:10.1021/ac050957q · Cited by 542 · see citing works
New Approaches to Sepsis: Molecular Diagnostics and Biomarkers
Reinhart, K., Bauer, M. W., Riedemann, N. C., & Hartog, C. S. (2012) · Clinical Microbiology Reviews · doi:10.1128/cmr.00016-12 · Cited by 528 · see citing works
Cytometric bead array: a multiplexed assay platform with applications in various areas of biology
Morgan, E., Varro, R., Sepulveda, H., Ember, J. A., Apgar, J. R., Wilson, J., Lowe, L., Chen, R., Shivraj, L., Agadir, A., et al. (2004) · Clinical Immunology · doi:10.1016/j.clim.2003.11.017 · Cited by 507 · see citing works
Aptamers as therapeutic and diagnostic agents
Brody, E. N., & Gold, L. (2000) · Reviews in Molecular Biotechnology · doi:10.1016/s1389-0352(99)00004-5 · Cited by 495 · see citing works
Selective Protein Capture by Epitope Imprinting
Nishino, H., Huang, C., & Shea, K. J. (2006) · Angewandte Chemie International Edition · doi:10.1002/anie.200503760 · Cited by 471 · see citing works
Prerequisites for cytokine measurements in clinical trials with multiplex immunoassays
de Jager, W., Bourcier, K., Rijkers, G. T., Prakken, B. J., & Seyfert‐Margolis, V. (2009) · BMC Immunology · doi:10.1186/1471-2172-10-52 · Cited by 428 · see citing works
Cytokine detection by antibody-based proximity ligation
Gullberg, M. T., Gustafsdottir, S., Schallmeiner, E., Jarvius, J., Bjarnegård, M., Betsholtz, C., Landegren, U. D., & Fredriksson, S. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0400552101 · Cited by 412 · see citing works
Cytokine release from innate immune cells: association with diverse membrane trafficking pathways
Lacy, P., & Stow, J. L. (2011) · Blood · doi:10.1182/blood-2010-08-265892 · Cited by 407 · see citing works
How Cytokine Networks Fuel Inflammation: Toward a cytokine-based disease taxonomy
Schett, G., Elewaut, D., McInnes, I. B., Dayer, J.-M., & Neurath, M. F. (2013) · Nature Medicine · doi:10.1038/nm.3260 · Cited by 406 · see citing works
Simultaneous quantitation of 15 cytokines using a multiplexed flow cytometric assay
Carson, R. T., & Vignali, D. A. A. (1999) · Journal of Immunological Methods · doi:10.1016/s0022-1759(99)00069-1 · Cited by 404 · see citing works
Inhibitory DNA Ligands to Platelet-Derived Growth Factor B-Chain
Green, L. S., JELLINEK, D. A., JENISON, R. D., et al. (1996) · Biochemistry · doi:10.1021/bi961544+ · Cited by 390 · see citing works
Towards molecularly imprinted polymers selective to peptides and proteins. The epitope approach
Rachkov, A. E., & Minoura, N. (2001) · Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology · doi:10.1016/s0167-4838(00)00226-0 · Cited by 376 · see citing works
Highly multiparametric analysis by mass cytometry
Ornatsky, O., Bandura, D. R., Baranov, V. I., Nitz, M., Winnik, M. A., & Tanner, S. D. (2010) · Journal of Immunological Methods · doi:10.1016/j.jim.2010.07.002 · Cited by 368 · see citing works
Critical review and perspective of macromolecularly imprinted polymers
Kryscio, D. R., & Peppas, N. A. (2011) · Acta Biomaterialia · doi:10.1016/j.actbio.2011.11.005 · Cited by 368 · see citing works
Multiplex bead array assays for detection of soluble cytokines: Comparisons of sensitivity and quantitative values among kits from multiple manufacturers
Khan, S. S., Smith, M. S., Reda, D., Suffredini, A. F., & McCoy, J. P. (2004) · Cytometry Part B Clinical Cytometry · doi:10.1002/cyto.b.20021 · Cited by 357 · see citing works
Microfluidic Single-Cell mRNA Isolation and Analysis
Marcus, J. S., Anderson, W. F., & Quake, S. R. (2006) · Analytical Chemistry · doi:10.1021/ac0519460 · Cited by 351 · see citing works
Inflammatory Cytokines in Heart Failure: Mediators and Markers
Gullestad, L. L., Ueland, T., Vinge, L. E., Finsen, A. V., Yndestad, A., & Aukrust, P. (2012) · Cardiology · doi:10.1159/000338166 · Cited by 350 · see citing works
The Cytokine Response to Human Traumatic Brain Injury: Temporal Profiles and Evidence for Cerebral Parenchymal Production
Helmy, A. E., Carpenter, K. L. H., Menon, D. K., Pickard, J. D., & Hutchinson, P. J. (2010) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2010.142 · Cited by 338 · see citing works
Polyfunctional responses by human T cells result from sequential release of cytokines
Han, Q., Bagheri, N., Bradshaw, E. M., Hafler, D. A., Lauffenburger, D. A., & Love, J. C. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1117194109 · Cited by 329 · see citing works
Conceptual and methodological issues relevant to cytokine and inflammatory marker measurements in clinical research
Zhou, X., Fragala, M. S., McElhaney, J. E., & Kuchel, G. A. (2010) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e32833cf3bc · Cited by 329 · see citing works
Aptamer-Based Electrochemical Biosensor for Interferon Gamma Detection
Liu, Y., Tuleouva, N., Ramanculov, E. M., & Revzin, A. (2010) · Analytical Chemistry · doi:10.1021/ac101409t · Cited by 326 · see citing works
Essential Role of IL-21 in B Cell Activation, Expansion, and Plasma Cell Generation during CD4+ T Cell-B Cell Collaboration
Kuchen, S., Robbins, R., Sims, G. P., Sheng, C., Phillips, T. M., Lipsky, P. E., & Ettinger, R. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.9.5886 · Cited by 326 · see citing works
Antibody-Based Protein Multiplex Platforms: Technical and Operational Challenges
Ellington, A. A., Kullo, I. J., Bailey, K. R., & Klee, G. G. (2009) · Clinical Chemistry · doi:10.1373/clinchem.2009.127514 · Cited by 314 · see citing works
Aptamer Modules as Sensors and Detectors
Famulok, M., & Mayer, G. (2011) · Accounts of Chemical Research · doi:10.1021/ar2000293 · Cited by 301 · see citing works
Heterogeneous immunoassays using magnetic beads on a digital microfluidic platform
Sista, R. S., Eckhardt, A. E., Srinivasan, V., et al. (2008) · Lab on a Chip · doi:10.1039/b807855f · Cited by 294 · see citing works
Sensitivity Improved Surface Plasmon Resonance Biosensor for Cancer Biomarker Detection Based on Plasmonic Enhancement
Law, W., Yong, K., Baev, A. S., et al. (2011) · ACS Nano · doi:10.1021/nn2009485 · Cited by 290 · see citing works
Validation and comparison of two multiplex technologies, Luminex® and Mesoscale Discovery, for human cytokine profiling
Chowdhury, F., Williams, A. P., & Johnson, P. (2008) · Journal of Immunological Methods · doi:10.1016/j.jim.2008.10.002 · Cited by 285 · see citing works
Multiplexed microsphere-based flow cytometric assays
Kellar, K. L., & Iannone, M. A. (2002) · Experimental Hematology · doi:10.1016/s0301-472x(02)00922-0 · Cited by 282 · see citing works
Current trends in quantitative proteomics
Elliott, M. H., SMITH, D. S. H., Parker, C. E., & Borchers, C. H. (2009) · Journal of Mass Spectrometry · doi:10.1002/jms.1692 · Cited by 274 · see citing works
Multiplexed Sandwich Immunoassays Using Electrochemiluminescence Imaging Resolved at the Single Bead Level
Deiss, F. T., LaFratta, C. N., Symer, M. M., et al. (2009) · Journal of the American Chemical Society · doi:10.1021/ja901876z · Cited by 268 · see citing works
Advances in human proteomics at high scale with the SOMAscan proteomics platform
Gold, L., Walker, J. J., Wilcox, S. K., & Williams, S. A. (2011) · New Biotechnology · doi:10.1016/j.nbt.2011.11.016 · Cited by 263 · see citing works
Zeptosens' protein microarrays: A novel high performance microarray platform for low abundance protein analysis
Pawlak, M., Schick, E., Bopp, M. A., Schneider, M. J., Oroszlan, P. L., & Ehrat, M. (2002) · PROTEOMICS · doi:10.1002/1615-9861(200204)2:4 · Cited by 258 · see citing works
Chemical Analysis of Single Cells
Lin, Y., Trouillon, R., Рустамовна, С. Г., & Ewing, A. G. (2011) · Analytical Chemistry · doi:10.1021/ac2009838 · Cited by 251 · see citing works
Selective enrichment of newly synthesized proteins for quantitative secretome analysis
Eichelbaum, K., Winter, M., Diaz, M. B., Herzig, S., & Krijgsveld, J. (2012) · Nature Biotechnology · doi:10.1038/nbt.2356 · Cited by 248 · see citing works
Developing Multiplexed Assays for Troponin I and Interleukin-33 in Plasma by Peptide Immunoaffinity Enrichment and Targeted Mass Spectrometry
Kuhn, E. W., Addona, T. A., Keshishian, H., Burgess, M. W., Mani, D. R., Lee, R. T., Sabatine, M. S., Gerszten, R. E., & Carr, S. A. (2009) · Clinical Chemistry · doi:10.1373/clinchem.2009.123935 · Cited by 247 · see citing works
Albumin depletion of human plasma also removes low abundance proteins including the cytokines
Granger, J. I., Siddiqui, J., Copeland, S., et al. (2005) · PROTEOMICS · doi:10.1002/pmic.200401331 · Cited by 229 · see citing works
Cell-surface sensors for real-time probing of cellular environments
Zhao, W., Schäfer, S., Choi, J. H., Yamanaka, Y. J., Lombardi, M. L., Bose, S., Carlson, A. L., Phillips, J. A., Teo, W., Droujinine, I. A., et al. (2011) · Nature Nanotechnology · doi:10.1038/nnano.2011.101 · Cited by 225 · see citing works
Cytokine networking of innate immunity cells: a potential target of therapy
Střı́ž, I., Brabcová, E., Kolesár, L., & Sekerková, A. (2014) · Clinical Science · doi:10.1042/cs20130497 · Cited by 224 · see citing works
Carbon Nanotube Microwell Array for Sensitive Electrochemiluminescent Detection of Cancer Biomarker Proteins
Sardesai, N. P., Barron, J. C., & Rusling, J. F. (2011) · Analytical Chemistry · doi:10.1021/ac201292q · Cited by 221 · see citing works
Cytokines as Biomarkers in Rheumatoid Arthritis
Burska, A. N., Boissinot, M., & Ponchel, F. (2014) · Mediators of Inflammation · doi:10.1155/2014/545493 · Cited by 220 · see citing works
Comparison of Multiplex Immunoassay Platforms
Fu, Q., Zhu, J., & Eyk, J. E. V. (2009) · Clinical Chemistry · doi:10.1373/clinchem.2009.135087 · Cited by 217 · see citing works
Too large to fit? Recent developments in macromolecular imprinting
Ge, Y., & Turner, A. P. F. (2008) · Trends in biotechnology · doi:10.1016/j.tibtech.2008.01.001 · Cited by 217 · see citing works
An immunological Interleukine-6 capacitive biosensor using perturbation with a potentiostatic step
Berggren, C., Bjarnason, B., & Johansson, G. (1998) · Biosensors and Bioelectronics · doi:10.1016/s0956-5663(98)00058-x · Cited by 212 · see citing works
Current trends in the development of the electrochemiluminescent immunosensors
Muzyka, K. (2013) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2013.11.011 · Cited by 211 · see citing works
Ultrasensitive Detection of Cancer Biomarkers in the Clinic by Use of a Nanostructured Microfluidic Array
Malhotra, R., Patel, V., Chikkaveeraiah, B. V., et al. (2012) · Analytical Chemistry · doi:10.1021/ac301392g · Cited by 207 · see citing works
Mapping of the secretome of primary isolates of mammalian cells, stem cells and derived cell lines
Skalníková, H. K., Motlík, J., Gadher, S. J., & Kovářová, H. (2010) · PROTEOMICS · doi:10.1002/pmic.201000402 · Cited by 204 · see citing works
High-sensitivity miniaturized immunoassays for tumor necrosis factor ? using microfluidic systems
Cesaro-Tadic, S., Dernick, G., Juncker, D., et al. (2004) · Lab on a Chip · doi:10.1039/b408964b · Cited by 202 · see citing works
Direct Proteomic Quantification of the Secretome of Activated Immune Cells
Meissner, F., Scheltema, R. A., Mollenkopf, H., & Mann, M. (2013) · Science · doi:10.1126/science.1232578 · Cited by 200 · see citing works
PET Imaging of Inflammation Biomarkers
Wu, C., Li, F., Niu, G., & Chen, X. S. (2013) · Theranostics · doi:10.7150/thno.6592 · Cited by 199 · see citing works
Diverse Roles of Macrophages in Atherosclerosis: From Inflammatory Biology to Biomarker Discovery
Gui, T., Shimokado, A., Sun, Y., Akasaka, T., & Muragaki, Y. (2012) · Mediators of Inflammation · doi:10.1155/2012/693083 · Cited by 198 · see citing works
Multidimensional analysis of the frequencies and rates of cytokine secretion from single cells by quantitative microengraving
Han, Q., Bradshaw, E. M., Nilsson, B., Hafler, D. A., & Love, J. C. (2010) · Lab on a Chip · doi:10.1039/b926849a · Cited by 195 · see citing works
Molecularly templated materials in chemical sensing
Holthoff, E. L., & Bright, F. V. (2007) · Analytica Chimica Acta · doi:10.1016/j.aca.2007.05.044 · Cited by 188 · see citing works
Real-Time Rolling Circle Amplification for Protein Detection
Yang, L., Fung, C. W., Cho, E. J., et al. (2007) · Analytical Chemistry · doi:10.1021/ac062186b · Cited by 186 · see citing works
Human asthma phenotypes: from the clinic, to cytokines, and back again
Bhakta, N. R., & Woodruff, P. G. (2011) · Immunological Reviews · doi:10.1111/j.1600-065x.2011.01032.x · Cited by 186 · see citing works
Parallel Picoliter RT-PCR Assays Using Microfluidics
Marcus, J. S., Anderson, W. F., & Quake, S. R. (2006) · Analytical Chemistry · doi:10.1021/ac0513865 · Cited by 185 · see citing works
Simple Fabrication of Antibody Microarrays on Nonfouling Polymer Brushes with Femtomolar Sensitivity for Protein Analytes in Serum and Blood
Hucknall, A., Kim, D., Rangarajan, S., et al. (2009) · Advanced Materials · doi:10.1002/adma.200803125 · Cited by 185 · see citing works
Biological and Technical Variables Affecting Immunoassay Recovery of Cytokines from Human Serum and Simulated Vaginal Fluid: A Multicenter Study
Fichorova, R. N., Richardson‐Harman, N., Alfano, M., et al. (2008) · Analytical Chemistry · doi:10.1021/ac702628q · Cited by 184 · see citing works
Interlaboratory Evaluation of Automated, Multiplexed Peptide Immunoaffinity Enrichment Coupled to Multiple Reaction Monitoring Mass Spectrometry for Quantifying Proteins in Plasma
Kuhn, E. W., Whiteaker, J. R., Mani, D. R., Jackson, A., Zhao, L., Pope, M. E., SMITH, D. S. H., Rivera, K. D., Anderson, N. L., Skates, S. J., et al. (2011) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m111.013854 · Cited by 183 · see citing works
Sensitive Immunoassay of a Biomarker Tumor Necrosis Factor-α Based on Poly(guanine)-Functionalized Silica Nanoparticle Label
Wang, J., Liu, G., Engelhard, M., & Lin, Y. (2006) · Analytical Chemistry · doi:10.1021/ac060809f · Cited by 175 · see citing works
Analytical Chemistry with Silica Sol-Gels: Traditional Routes to New Materials for Chemical Analysis
Walcarius, A., & Collinson, M. M. (2009) · Annual Review of Analytical Chemistry · doi:10.1146/annurev-anchem-060908-155139 · Cited by 174 · see citing works
An Evaluation of Commercial Fluorescent Bead-Based Luminex Cytokine Assays
Siawaya, J. F. D., Roberts, T., de Villiers, C. B., Black, G. F., Golakai, H. J., Stanley, K., Bapela, N. B., Hoal, E. G., Parida, S. K., van Helden, P. D., et al. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002535 · Cited by 173 · see citing works
A Microchip-Based Multianalyte Assay System for the Assessment of Cardiac Risk
Christodoulides, N., Tran, M., Floriano, P. N., et al. (2002) · Analytical Chemistry · doi:10.1021/ac011150a · Cited by 169 · see citing works
Synthetic DNA Aptamers to Detect Protein Molecular Variants in a High‐Throughput Fluorescence Quenching Assay
Fang, X., Sen, A., Vicéns, M. C., et al. (2003) · ChemBioChem · doi:10.1002/cbic.200300615 · Cited by 168 · see citing works
Anti‐VEGF Aptamer (Pegaptanib) Therapy for Ocular Vascular Diseases
Ng, E. W. M., & Adamis, A. P. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1348.062 · Cited by 161 · see citing works
Real-time label-free immunoassay of interferon-gamma and prostate-specific antigen using a Fiber-Optic Localized Surface Plasmon Resonance sensor
Jeong, H., Erdene, N., Park, J. H., et al. (2012) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2012.08.013 · Cited by 160 · see citing works
Lab‐on‐a‐Chip Methods for Point‐of‐Care Measurements of Salivary Biomarkers of Periodontitis
Christodoulides, N. J., Floriano, P. N., Miller, C. S., Ebersole, J. L., MOHANTY, S., Dharshan, P., Griffin, M. J., Lennart, A., Ballard, K., King, C. P., et al. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1384.035 · Cited by 158 · see citing works
Membrane Array Characterization of 80 Chemokines, Cytokines, and Growth Factors in Open- and Closed-Eye Tears: Angiogenin and Other Defense System Constituents
Sack, R. A., Conradi, L., Krumholz, D. M., et al. (2005) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.04-0760 · Cited by 155 · see citing works
Molecular imprinting of proteins emerging as a tool for protein recognition
Takeuchi, T., & Hishiya, T. (2008) · Organic & Biomolecular Chemistry · doi:10.1039/b715737c · Cited by 155 · see citing works
Multiplex measurement of proinflammatory cytokines in human serum: Comparison of the Meso Scale Discovery electrochemiluminescence assay and the Cytometric Bead Array
Dabitao, D., Margolick, J. B., Lopez, J. A., & Bream, J. H. (2011) · Journal of Immunological Methods · doi:10.1016/j.jim.2011.06.033 · Cited by 154 · see citing works
A high-throughput single-cell analysis of human CD8+ T cell functions reveals discordance for cytokine secretion and cytolysis
Varadarajan, N., Jülg, B. D., Yamanaka, Y. J., Chen, H., Ogunniyi, A. O., McAndrew, E. G., Porter, L. C., Trocha, A. K., Hill, B. J., Douek, D. C., et al. (2011) · Journal of Clinical Investigation · doi:10.1172/jci58653 · Cited by 153 · see citing works
Variables That Affect Assays for Plasma Cytokines and Soluble Activation Markers
Aziz, N., Nishanian, P., Mitsuyasu, R. T., Detels, R., & Fahey, J. L. (1999) · Clinical and Diagnostic Laboratory Immunology · doi:10.1128/cdli.6.1.89-95.1999 · Cited by 151 · see citing works
Development of an Aptamer Beacon for Detection of Interferon-Gamma
Tuleuova, N., Jones, C. N., Yan, J., et al. (2010) · Analytical Chemistry · doi:10.1021/ac9025237 · Cited by 145 · see citing works
Photoaptamer arrays applied to multiplexed proteomic analysis
Bock, C., Coleman, M., Collins, B. D., et al. (2004) · PROTEOMICS · doi:10.1002/pmic.200300631 · Cited by 144 · see citing works
Multiplexed Analysis of Human Cytokines by Use of the FlowMetrix System
Oliver, K. G., Kettman, J. R., & Fulton, R. J. (1998) · Clinical Chemistry · doi:10.1093/clinchem/44.9.2057 · Cited by 140 · see citing works
Highly Sensitive Detection of Protein with Aptamer-Based Target-Triggering Two-Stage Amplification
Zhang, Z.-Z., & Zhang, C. (2012) · Analytical Chemistry · doi:10.1021/ac2029002 · Cited by 140 · see citing works
Multiplexed Protein Quantification with Barcoded Hydrogel Microparticles
Appleyard, D. C., Chapin, S. C., & Doyle, P. S. (2010) · Analytical Chemistry · doi:10.1021/ac1022343 · Cited by 139 · see citing works
Protein Quantitation through Targeted Mass Spectrometry: The Way Out of Biomarker Purgatory?
Carr, S. A., & Anderson, L. (2008) · Clinical Chemistry · doi:10.1373/clinchem.2008.114686 · Cited by 139 · see citing works
Nanoparticle‐Based Electrochemical Bioassays of Proteins
Wang, J. (2007) · Electroanalysis · doi:10.1002/elan.200603789 · Cited by 138 · see citing works
Label-free technologies for quantitative multiparameter biological analysis
Qavi, A. J., Washburn, A. L., Byeon, J.-Y., & Bailey, R. C. (2009) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-009-2637-8 · Cited by 136 · see citing works
Droplet-based microfluidic platforms for single T cell secretion analysis of IL-10 cytokine
Konry, T., Dominguez‐Villar, M., Baecher‐Allan, C., Hafler, D. A., & Yarmush, M. L. (2010) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2010.09.006 · Cited by 134 · see citing works
Sensitivity by combination: immuno-PCR and related technologies
Adler, M., Wacker, R., & Niemeyer, C. M. (2008) · The Analyst · doi:10.1039/b718587c · Cited by 134 · see citing works
Sensitive protein detection via triple-binder proximity ligation assays
Schallmeiner, E., Oksanen, E., Ericsson, O., et al. (2006) · Nature Methods · doi:10.1038/nmeth974 · Cited by 133 · see citing works
Variable estimates of cytokine levels produced by commercial ELISA kits: results using international cytokine standards
Ledur, A., Fitting, C., David, B., et al. (1995) · Journal of Immunological Methods · doi:10.1016/0022-1759(95)00184-c · Cited by 131 · see citing works
Molecular Imaging of Inflammation/Infection: Nuclear Medicine and Optical Imaging Agents and Methods
Signore, A., Mather, S. J., Piaggio, G., Malviya, G., & Dierckx, R. A. (2010) · Chemical Reviews · doi:10.1021/cr900351r · Cited by 129 · see citing works
Proximity ligation assays for sensitive and specific protein analyses
Gustafsdottir, S., Schallmeiner, E., Fredriksson, S., Gullberg, M. T., Söderberg, O., Jarvius, M., Jarvius, J., Howell, M., & Landegren, U. D. (2005) · Analytical Biochemistry · doi:10.1016/j.ab.2005.01.018 · Cited by 127 · see citing works
Photostable Single-Molecule Nanoparticle Optical Biosensors for Real-Time Sensing of Single Cytokine Molecules and Their Binding Reactions
Huang, T., Nallathamby, P. D., & Xu, X. N. (2008) · Journal of the American Chemical Society · doi:10.1021/ja8068853 · Cited by 126 · see citing works
Microdialysis of Cytokines: Methodological Considerations, Scanning Electron Microscopy, and Determination of Relative Recovery
Helmy, A. E., Carpenter, K. L. H., Skepper, J. N., et al. (2009) · Journal of Neurotrauma · doi:10.1089/neu.2008.0719 · Cited by 126 · see citing works
Microdialysis of large molecules
Clough, G. (2005) · The AAPS Journal · doi:10.1208/aapsj070369 · Cited by 125 · see citing works
Electrochemical immunosensor of tumor necrosis factor α based on alkaline phosphatase functionalized nanospheres
Yin, Z., Liu, Y., Jiang, L., et al. (2010) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2010.03.025 · Cited by 124 · see citing works
Optical biosensors : today and tomorrow
Ligler, F. S., & Taitt, C. R. (2008) · doi:10.1016/b978-0-444-53125-4.x5001-3 · Cited by 123 · see citing works
Colorimetric Bio-Barcode Amplification Assay for Cytokines
Nam, J., Wise, A. R., & Groves, J. T. (2005) · Analytical Chemistry · doi:10.1021/ac0513764 · Cited by 123 · see citing works
On the existence of cytokines in invertebrates
Beschin, A., Bilej, M., Torreele, E., & BAETSELIER, P. D. (2001) · Cellular and Molecular Life Sciences · doi:10.1007/pl00000901 · Cited by 121 · see citing works
Immunochromatographic techniques - a critical review
Weller, M. G. (2000) · Fresenius Journal of Analytical Chemistry · doi:10.1007/s002160051558 · Cited by 120 · see citing works
Detection of proteins using a colorimetric bio-barcode assay
Nam, J., Jang, K., & Groves, J. T. (2007) · Nature Protocols · doi:10.1038/nprot.2007.201 · Cited by 120 · see citing works
Silicon Photonic Microring Resonators for Quantitative Cytokine Detection and T-Cell Secretion Analysis
Luchansky, M. S., & Bailey, R. C. (2010) · Analytical Chemistry · doi:10.1021/ac902725q · Cited by 120 · see citing works
Protein microarrays and quantum dot probes for early cancer detection
Zajac, A., Song, D., Qian, W. P., et al. (2007) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2007.02.019 · Cited by 118 · see citing works
The Clinical Usefulness of the Measurement of Cytokines
Bienvenu, J., Monneret, G., Fabien, N., & Revillard, J. (2000) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm.2000.040 · Cited by 117 · see citing works
Microdialysis sampling of cytokines
Ao, X., & Stenken, J. A. (2006) · Methods · doi:10.1016/j.ymeth.2005.11.012 · Cited by 116 · see citing works
Self-citation
Comparison of cytokine measurements using ELISA, ELISPOT and semi-quantitative RT-PCR
Favre, N., Bordmann, G., & Rudin, W. (1997) · Journal of Immunological Methods · doi:10.1016/s0022-1759(97)00033-1 · Cited by 115 · see citing works
Photoacoustic tomography of joints aided by an Etanercept-conjugated gold nanoparticle contrast agent—anex vivopreliminary rat study
Chamberland, D. L., Agarwal, A., Kotov, N. A., Fowlkes, J. B., Carson, P. L., & Wang, X. (2008) · Nanotechnology · doi:10.1088/0957-4484/19/9/095101 · Cited by 115 · see citing works
A Microdialysis Technique for Routine Measurement of Macromolecules in the Injured Human Brain
Hillman, J., Åneman, O., Anderson, C. D., Sjögren, F., Säberg, C., & Mellergård, P. (2005) · Neurosurgery · doi:10.1227/01.neu.0000159711.93592.8d · Cited by 113 · see citing works
Quantification of Cytokines Involved in Wound Healing Using Surface Plasmon Resonance
Battaglia, T. M., Masson, J., Sierks, M. R., et al. (2005) · Analytical Chemistry · doi:10.1021/ac050568w · Cited by 112 · see citing works
In vivo cytokine-associated responses to biomaterials
Schutte, R. J., Xie, L., Klitzman, B., & Reichert, W. M. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2008.09.026 · Cited by 111 · see citing works
Electrochemical Aptameric Recognition System for a Sensitive Protein Assay Based on Specific Target Binding-Induced Rolling Circle Amplification
Wu, Z., Zhou, H. H., Zhang, S., et al. (2010) · Analytical Chemistry · doi:10.1021/ac902400n · Cited by 110 · see citing works
Characterization of the evanescent field profile and bound mass sensitivity of a label-free silicon photonic microring resonator biosensing platform
Luchansky, M. S., Washburn, A. L., Martin, T. A., Iqbal, M., Gunn, L. C., & Bailey, R. C. (2010) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2010.07.010 · Cited by 109 · see citing works
Chemical Sensors Based on Molecularly Imprinted Sol-Gel Materials
Mujahid, A., Lieberzeit, P. A., & Dickert, F. L. (2010) · Materials · doi:10.3390/ma3042196 · Cited by 109 · see citing works
Diffractometric Detection of Proteins Using Microbead-Based Rolling Circle Amplification
Lee, J., İçöz, K., Roberts, A., Ellington, A. D., & Savran, C. A. (2009) · Analytical Chemistry · doi:10.1021/ac901716d · Cited by 108 · see citing works
Quantification of human insulin‐like growth factor‐1 and qualitative detection of its analogues in plasma using liquid chromatography/electrospray ionisation tandem mass spectrometry
Bredehöft, M., Schänzer, W., & Thevis, M. (2008) · Rapid Communications in Mass Spectrometry · doi:10.1002/rcm.3388 · Cited by 107 · see citing works
Advances in Surface Plasmon Resonance Sensing with Nanoparticles and Thin Films: Nanomaterials, Surface Chemistry, and Hybrid Plasmonic Techniques
Bolduc, O. R., & Masson, J. (2011) · Analytical Chemistry · doi:10.1021/ac2012976 · Cited by 105 · see citing works
Mass-spectrometry-based clinical proteomics – a review and prospective
Parker, C. E., Pearson, T. W., Anderson, N. L., & Borchers, C. H. (2010) · The Analyst · doi:10.1039/c0an00105h · Cited by 104 · see citing works
A microfluidic electrochemiluminescent device for detecting cancer biomarker proteins
Sardesai, N. P., Kadimisetty, K., Faria, R. C., & Rusling, J. F. (2013) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-012-6656-5 · Cited by 103 · see citing works
Chemical Analysis of Single Cells
Borland, L. M., Kottegoda, S., Phillips, K. S., et al. (2008) · Annual Review of Analytical Chemistry · doi:10.1146/annurev.anchem.1.031207.113100 · Cited by 102 · see citing works
Integrated Nanoplasmonic Sensing for Cellular Functional Immunoanalysis Using Human Blood
Oh, B.-R., Huang, N., Chen, W., et al. (2014) · ACS Nano · doi:10.1021/nn406370u · Cited by 100 · see citing works
Polymer-Functionalized Silica Nanosphere Labels for Ultrasensitive Detection of Tumor Necrosis Factor-alpha
Yuan, L., Hua, X., Wu, Y., et al. (2011) · Analytical Chemistry · doi:10.1021/ac201558w · Cited by 100 · see citing works
Detection of Proteins in Serum by Micromagnetic Aptamer PCR (MAP) Technology
Csordas, A. T., Gerdon, A. E., Adams, J. D., et al. (2009) · Angewandte Chemie International Edition · doi:10.1002/anie.200904846 · Cited by 100 · see citing works
A Short DNA Aptamer That Recognizes TNFα and Blocks Its Activity in Vitro
Orava, E. W., Jarvik, N., Shek, Y. L., Sidhu, S. S., & Gariépy, J. (2012) · ACS Chemical Biology · doi:10.1021/cb3003557 · Cited by 99 · see citing works
A microdevice for multiplexed detection of T-cell-secreted cytokines
Zhu, H., Stybayeva, G., Macal, M., et al. (2008) · Lab on a Chip · doi:10.1039/b810244a · Cited by 98 · see citing works
Report from a workshop on multianalyte microsphere assays
Earley, M. C., Vogt, R. F., Shapiro, H. M., et al. (2002) · Cytometry · doi:10.1002/cyto.10140 · Cited by 98 · see citing works
Micropatterned Aptasensors for Continuous Monitoring of Cytokine Release from Human Leukocytes
Liu, Y., Yan, J., Howland, M. C., Kwa, T., & Revzin, A. (2011) · Analytical Chemistry · doi:10.1021/ac202117g · Cited by 97 · see citing works
Cytokines in acute kidney injury (AKI)
Lee, D. W., Faubel, S. G., & Edelstein, C. L. (2011) · Clinical Nephrology · doi:10.5414/cn106921 · Cited by 95 · see citing works
Critical Cytokine Pathways to Cardiac Inflammation
Rose, N. R. (2011) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2011.0057 · Cited by 92 · see citing works
Electrochemical enzyme immunoassay using model labels
Li, X., Yang, X., & Zhang, S. (2008) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2008.04.002 · Cited by 92 · see citing works
Signal integration, crosstalk mechanisms and networks in the function of inflammatory cytokines
Schmitz, M. L., Weber, A., Roxlau, T., Gaestel, M., & Kracht, M. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2011.06.019 · Cited by 92 · see citing works
Fiber-Optic Microsphere-Based Antibody Array for the Analysis of Inflammatory Cytokines in Saliva
Blicharz, T. M., Siqueira, W. L., Helmerhorst, E. J., Oppenheim, F. G., Wexler, P. J., Little, F. F., & Walt, D. R. (2009) · Analytical Chemistry · doi:10.1021/ac802181j · Cited by 91 · see citing works
Macrophage–neutrophil interaction: A paradigm for chronic inflammation revisited
Lefkowitz, D. L., & Lefkowitz, S. S. (2001) · Immunology and Cell Biology · doi:10.1046/j.1440-1711.2001.01020.x · Cited by 90 · see citing works
Application of Photonic Crystal Enhanced Fluorescence to a Cytokine Immunoassay
Mathias, P. C., Ganesh, N., & Cunningham, B. T. (2008) · Analytical Chemistry · doi:10.1021/ac801377k · Cited by 89 · see citing works
Lateral flow assay for simultaneous detection of cellular- and humoral immune responses
Corstjens, P. L. A. M., de Dood, C. J., Schip, J. J. V. D. P.-V., et al. (2011) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2011.06.983 · Cited by 89 · see citing works
Detecting Cytokine Release from Single T-cells
Zhu, H., Stybayeva, G., Silangcruz, J., Yan, J., Ramanculov, E. M., Dandekar, S., George, M. D., & Revzin, A. (2009) · Analytical Chemistry · doi:10.1021/ac901390j · Cited by 89 · see citing works
Conjugation of Functionalized Gadolinium Metallofullerenes with IL-13 Peptides for Targeting and Imaging Glial Tumors
Fillmore, H. L., Shultz, M. D., Henderson, S. C., et al. (2011) · Nanomedicine · doi:10.2217/nnm.10.134 · Cited by 89 · see citing works
The role of cytokines in the pathogenesis and treatment of HIV infection
Catálfamo, M., Saout, C. L., & Lane, H. C. (2012) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2012.05.007 · Cited by 88 · see citing works
Finger-actuated, self-contained immunoassay cassettes
Qiu, X., Thompson, J. A., Chen, Z., et al. (2009) · Biomedical Microdevices · doi:10.1007/s10544-009-9334-4 · Cited by 88 · see citing works
Resistive Pulse Sensing of Analyte‐Induced Multicomponent Rod Aggregation Using Tunable Pores
Platt, M., Willmott, G. R., & Lee, G. U. (2012) · Small · doi:10.1002/smll.201200058 · Cited by 88 · see citing works
Detection of Proteins in Serum by Micromagnetic Aptamer PCR (MAP) Technology
Csordas, A. T., Gerdon, A. E., Adams, J. D., et al. (2009) · Angewandte Chemie · doi:10.1002/ange.200904846 · Cited by 87 · see citing works
Detection and measurement of cytokines
Thorpe, R., Wadhwa, M., Bird, C. R., & Mire‐Sluis, A. R. (1992) · Blood Reviews · doi:10.1016/0268-960x(92)90025-l · Cited by 86 · see citing works
The nucleic acid ligand. A new tool for molecular recognition
McGown, L. B., Joseph, M. J., Pitner, J. B., et al. (1995) · Analytical Chemistry · doi:10.1021/ac00117a002 · Cited by 84 · see citing works
Detection of spontaneous and antigen-induced human interleukin-4 responses in vitro: comparison of ELISPOT, a novel ELISA and real-time RT-PCR
Ekerfelt, C., Ernerudh, J., & Jenmalm, M. C. (2002) · Journal of Immunological Methods · doi:10.1016/s0022-1759(01)00520-8 · Cited by 82 · see citing works
Fiber-optic particle plasmon resonance sensor for detection of interleukin-1β in synovial fluids
Chiang, C.-Y., Hsieh, M., Huang, K.-W., Chau, L., Chang, C., & Lyu, S. (2010) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2010.08.047 · Cited by 82 · see citing works
Magnetic microbead-based electrochemical immunoassays
Kuramitz, H. (2009) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-009-2650-y · Cited by 82 · see citing works
Rapid analysis of inflammatory cytokines in cerebrospinal fluid using chip‐based immunoaffinity electrophoresis
Phillips, T. M. (2004) · Electrophoresis · doi:10.1002/elps.200305873 · Cited by 82 · see citing works
Cytokine quantitation: technologies and applications
Sachdeva, N. K. (2007) · Frontiers in bioscience · doi:10.2741/2418 · Cited by 80 · see citing works
Exercise Training, Physical Fitness and the Growth Hormone-Insulin-Like Growth Factor-1 Axis and Cytokine Balance
Eliakim, A., & Nemet, D. (2010) · Medicine and sport science/Medicine and sport · doi:10.1159/000321977 · Cited by 77 · see citing works
Investigation of Molecular Beacon Aptamer‐Based Bioassay for Platelet‐Derived Growth Factor Detection
Vicéns, M. C., Sen, A., Vanderlaan, A., et al. (2005) · ChemBioChem · doi:10.1002/cbic.200400308 · Cited by 76 · see citing works
Detection of tumor necrosis factor (TNF-α) in cell culture medium with label free electrochemical impedance spectroscopy
Pui, T. S., Kongsuphol, P., Arya, S. K., et al. (2013) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2013.02.019 · Cited by 74 · see citing works
Proteomics and diagnostics: Let's Get Specific, again
Zichi, D., Eaton, B. E., Singer, B. S., & Gold, L. (2008) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2008.01.016 · Cited by 73 · see citing works
Reproducibility of serum cytokines and growth factors
Gu, Y., Zeleniuch‐Jacquotte, A., Linkov, F. Y., Koenig, K. L., Liu, M., Velikokhatnaya, L., Shore, R. E., Marrangoni, A., Toniolo, P. G., Lokshin, A. E., et al. (2008) · Cytokine · doi:10.1016/j.cyto.2008.10.014 · Cited by 72 · see citing works
Macrophages in tissues and in vitro
Gordon, S., Fraser, I. P., Nath, D., Hughes, D. A., & Clarke, S. (1992) · Current Opinion in Immunology · doi:10.1016/0952-7915(92)90119-y · Cited by 72 · see citing works
Programmable Nano-Bio-Chip Sensors: Analytical Meets Clinical
Jokerst, J. V., Jacobson, J. W., Bhagwandin, B., et al. (2010) · Analytical Chemistry · doi:10.1021/ac901743u · Cited by 71 · see citing works
Quantification of Interleukin-6 in cell culture medium using surface plasmon resonance biosensors
Chou, T.-H., Chuang, C., & Wu, C. (2010) · Cytokine · doi:10.1016/j.cyto.2010.04.004 · Cited by 69 · see citing works
Surface plasmon resonance immunoassay for the detection of the TNFα biomarker in human serum
Martínez-Perdiguero, J., Retolaza, A., Bujanda, L., & Merino, S. (2013) · Talanta · doi:10.1016/j.talanta.2013.11.063 · Cited by 68 · see citing works
Ultrasensitive Detection of Cytokines Enabled by Nanoscale ZnO Arrays
Adalsteinsson, V. A., Parajuli, O., Kepics, S., et al. (2008) · Analytical Chemistry · doi:10.1021/ac800747q · Cited by 67 · see citing works
Photoproteins in Bioanalysis
(2006) · Wiley eBooks · doi:10.1002/3527609148 · Cited by 66 · see citing works
The physics of life: one molecule at a time
Leake, M. C. (2012) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2012.0248 · Cited by 65 · see citing works
Therapeutic potential of anti–interleukin‐17A aptamer: Suppression of interleukin‐17A signaling and attenuation of autoimmunity in two mouse models
Ishiguro, A., Akiyama, T., Adachi, H., Inoue, J., & Nakamura, Y. (2010) · Arthritis & Rheumatism · doi:10.1002/art.30108 · Cited by 64 · see citing works
The Generation and Characterization of Antagonist RNA Aptamers to Human Oncostatin M
Rhodes, A., Deakin, A. M., Spaull, J. R., et al. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m002981200 · Cited by 63 · see citing works
Quantification of tumor necrosis factor-α and matrix metalloproteinases-3 in synovial fluid by a fiber-optic particle plasmon resonance sensor
Huang, Y., Chiang, C.-Y., Li, C.-H., et al. (2013) · The Analyst · doi:10.1039/c3an00276d · Cited by 61 · see citing works
Quantitative cell line based bioassays for human cytokines
Mire‐Sluis, A. R., Page, L., & Thorpe, R. (1995) · Journal of Immunological Methods · doi:10.1016/0022-1759(95)00220-1 · Cited by 60 · see citing works
Performance evaluation of cytometric bead assays for the measurement of lung cytokines in two rodent models
Young, S., Antonini, J. M., Roberts, J. R., et al. (2007) · Journal of Immunological Methods · doi:10.1016/j.jim.2007.11.004 · Cited by 59 · see citing works
Rapid and sensitive detection of cytokines using functionalized gold nanoparticle-based immuno-PCR, comparison with immuno-PCR and ELISA
Potůčková, L., Franko, F., Bambousková, M., et al. (2011) · Journal of Immunological Methods · doi:10.1016/j.jim.2011.06.012 · Cited by 57 · see citing works
Analysis of recombinant cytokines in human body fluids by immunoaffinity capillary electrophoresis
Phillips, T. M., & Dickens, B. F. (1998) · Electrophoresis · doi:10.1002/elps.1150191632 · Cited by 57 · see citing works
Templated xerogels as platforms for biomolecule-less biomolecule sensors
Tao, Z., Tehan, E. C., Bukowski, R. M., et al. (2006) · Analytica Chimica Acta · doi:10.1016/j.aca.2006.01.076 · Cited by 57 · see citing works
Measurement of cytokines by bioassays: Theory and application
Meager, A. (2006) · Methods · doi:10.1016/j.ymeth.2005.11.005 · Cited by 57 · see citing works
Cytokines and cytokine measurements in a clinical laboratory
Whiteside, T. L. (1994) · Clinical and Diagnostic Laboratory Immunology · doi:10.1128/cdli.1.3.257-260.1994 · Cited by 57 · see citing works
Microdialysis in Drug Development
MÃ¼ller, M. (2012) · AAPS advances in the pharmaceutical sciences series · doi:10.1007/978-1-4614-4815-0 · Cited by 57 · see citing works
Clinical Applications for Biomarkers of Acute and Chronic Graft-versus-Host Disease
Levine, J. E., Paczesny, S., & Sarantopoulos, S. (2012) · Transplantation and Cellular Therapy · doi:10.1016/j.bbmt.2011.10.019 · Cited by 56 · see citing works
What Can Microdialysis Tell Us About the Temporal and Spatial Generation of Cytokines in Allergen-Induced Responses in Human Skin In Vivo?
Clough, G., Jackson, C. L., Lee, J. J. P., et al. (2007) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5700930 · Cited by 55 · see citing works
History of inductively coupled plasma mass spectrometry-based immunoassays
Giesen, C., Waentig, L., Panne, U., & Jakubowski, N. (2012) · Spectrochimica Acta Part B Atomic Spectroscopy · doi:10.1016/j.sab.2012.06.009 · Cited by 55 · see citing works
Multiplex serum biomarker assessments: technical and biostatistical issues
Butterfield, L. H., Potter, D. M., & Kirkwood, J. M. (2011) · Journal of Translational Medicine · doi:10.1186/1479-5876-9-173 · Cited by 55 · see citing works
Inflammatory Cytokines, Growth Factors, and Depression
Lotrich, F. E. (2012) · Current Pharmaceutical Design · doi:10.2174/138161212803523680 · Cited by 55 · see citing works
Biodistribution, pharmacokinetics and metabolism of interleukin‐1 receptor antagonist (IL‐1RA) using [18F]‐IL1RA and PET imaging in rats
Cawthorne, C., Prenant, C., Smigova, A., Julyan, P. J., Maroy, R., Herholz, K., Rothwell, N. J., & Boutin, H. (2010) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2010.01068.x · Cited by 54 · see citing works

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Research works printed but not linked: 3

[190]Rishpon J Buchner V Electrochemical antibody-based sensors Elsevier Science B.V 2005 329 73
[194]Rusling JF Kumar CV Gutkind JS Patel V Measurement of biomarker proteins for point-of-care early detection and monitoring of cancer Analyst (Cambridge, U K) 2010 135 2496 511 PMC2997816 20614087
[279]Westerink BHC Cremers TIFH Handbook of Microdialysis Sampling: Methods, Applications, and Clinical Aspects Amsterdam Academic Press 2007

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Kartikasari, A. E. R., Huertas, C. S., Mitchell, A., & Plebanski, M. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.692142 · Cited by 343 · see citing works
“July 2021 | Volume 11 | Article 692142 In a large collaborative international study, twelve laboratories compared various immunoassays including ELISA, Luminex, and chemiluminescence assays to measure human cytokines, IL-1b and IL-6.”
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Idiosyncrasies of Thermofluorimetric Aptamer Binding Assays
Damase, T. R., & Allen, P. B. (2019) · BioTechniques · doi:10.2144/btn-2018-0128 · Cited by 10 · see citing works
Aptamer cocktails: Enhancement of sensing signals compared to single use of aptamers for detection of bacteria
Kim, Y. S., Chung, J., Song, M., et al. (2013) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2013.11.003 · Cited by 90 · see citing works
An aptamer cocktail-based electrochemical aptasensor for direct capture and rapid detection of tetracycline in honey
Huang, Y., Yan, X.-C., Zhao, L., et al. (2019) · Microchemical Journal · doi:10.1016/j.microc.2019.104179 · Cited by 41 · see citing works
Selecting DNA aptamers for endotoxin separation
Ying, G., Zhu, F., Yu, Y., et al. (2015) · Biotechnology Letters · doi:10.1007/s10529-015-1839-8 · Cited by 6 · see citing works
Aptameric sensors based on structural change for diagnosis
Abe, K., Ogasawara, D., Yoshida, W., et al. (2010) · Faraday Discussions · doi:10.1039/c005359g · Cited by 9 · see citing works

Authors: Stenken, J. A., & Poschenrieder, A. J.
Affiliations: University of Arkansas at Fayetteville (US)
Technical University of Munich (DE)
Corresponding author: Stenken, Julie A.
ORCID: Stenken, Julie A.
Poschenrieder, Andreas J.
Venue: Analytica Chimica Acta
Publisher: Elsevier BV
Published: 2015-01
Volume: 853
Pages: 95-115
ISSN: 0003-2670 (ISSN-L)
DOI: 10.1016/j.aca.2014.10.009
PMC: PMC4717841
OpenAlex: W2021618744
Cited by: 302
References: 287
Citations by year: 2026: 18 · 2025: 26 · 2024: 25 · 2023: 37 · 2022: 32 · 2021: 43 · 2020: 31 · 2019: 25 · 2018: 26 · 2017: 13 · 2016: 19 · 2015: 7
FWCI: 1.22
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Analytica Chimica Acta (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Neurological Disorders and Stroke (R21NS075874)
National Institute of Biomedical Imaging and Bioengineering (R01EB001441, R01EB014404)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Advanced Biosensing Techniques and Applications
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Advanced biosensing and bioanalysis techniques
Physical Sciences › Chemistry › Spectroscopy › Advanced Proteomics Techniques and Applications
Keywords: cytokines, immunoassay, ELISA, bead-based immunoassay, flow cytometry, aptamers, electrochemical biosensor, mass spectrometry, cytokine biomarkers, inflammatory diseases
MeSH terms: Antibodies, Flow Cytometry, Humans, Immunoassay, Mass Spectrometry, Cytokines, Surface Plasmon Resonance, Microfluidics, Aptamers, Nucleotide, Nanoparticles, Electrochemical Techniques

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