The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
EGFR-Targeted Magnetic Nanoparticle Heaters Kill Cancer Cells without a Perceptible Temperature Rise
Abstract
It is currently believed that magnetic nanoparticle heaters (MNHs) can kill cancer cells only when the temperature is raised above 43 °C due to energy dissipation in an alternating magnetic field. On the other hand, simple heat conduction arguments indicate that in small tumors or single cells the relative rates of energy dissipation and heat conduction result in a negligible temperature rise, thus limiting the potential of MNHs in treating small tumors and metastatic cancer. Here we demonstrate that internalized MNHs conjugated to epidermal growth factor (EGF) and which target the epidermal growth factor receptor (EGFR) do result in a significant (up to 99.9%) reduction in cell viability and clonogenic survival in a thermal heat dose dependent manner, without the need for a perceptible temperature rise. The effect appears to be cell type specific and indicates that magnetic nanoparticles in alternating magnetic fields may effectively kill cancer cells under conditions previously considered as not possible.
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Citations
Cites
The effect of thermotherapy using magnetic nanoparticles on rat malignant glioma
Jordan, A., Scholz, R., Maier-Hauff, K., van Landeghem, F. K. H., Waldoefner, N., Teichgraeber, U., Pinkernelle, J., Bruhn, H., Neumann, F., Thiesen, B., et al. (2006) · Journal of Neuro-Oncology · doi:10.1007/s11060-005-9059-z · Cited by 459
Cited by
Fundamentals and advances in magnetic hyperthermia
Périgo, E. A., Hemery, G., Sandre, O., Ortega, D., Garaio, E., Plazaola, F., & Teran, F. J. (2015) · Applied Physics Reviews · doi:10.1063/1.4935688 · Cited by 836
Dutz, S., & Hergt, R. (2013) · International Journal of Hyperthermia · doi:10.3109/02656736.2013.822993 · Cited by 522
Tay, Z. W., Chandrasekharan, P., Chiu-Lam, A., Hensley, D. W., Dhavalikar, R., Zhou, X. Y., Yu, E. Y., Goodwill, P. W., Zheng, B., Rinaldi, C., et al. (2018) · ACS Nano · doi:10.1021/acsnano.8b00893 · Cited by 459
Nanoparticles for Imaging, Sensing, and Therapeutic Intervention
Bogart, L. K., Pourroy, G., Murphy, C. J., Puntes, V., Pellegrino, T., Rosenblum, D., Peer, D., & Lévy, R. (2014) · ACS Nano · doi:10.1021/nn500962q · Cited by 295
Design of iron oxide-based nanoparticles for MRI and magnetic hyperthermia
Blanco-Andujar, C., Walter, A., Cotin, G., Bordeianu, C., Mertz, D., Felder-Flesch, D., & Begin-Colin, S. (2016) · Nanomedicine · doi:10.2217/nnm-2016-5001 · Cited by 276
Metadata
- Authors
- Creixell, M., Bohórquez, A. C., Torres-Lugo, M., & Rinaldi, C.
- Venue
- ACS Nano
- Publisher
- American Chemical Society (ACS)
- Published
- 2011-08-22
- Volume
- 5
- Issue
- 9
- Pages
- 7124-7129
- ISSN
- 1936-0851 (ISSN-L)
- 1936-086X
- OpenAlex
- W2315718304
- Cited by
- 325
- References
- 1
- FWCI
- 15.86
- Type
- journal article
- Language
- en
- Open access
- closed
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- Creixell, M., Bohórquez, A. C., Torres-Lugo, M., & Rinaldi, C. (2011). EGFR-Targeted Magnetic Nanoparticle Heaters Kill Cancer Cells without a Perceptible Temperature Rise. ACS Nano. https://doi.org/10.1021/nn201822b
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