The effect of thermotherapy using magnetic nanoparticles on rat malignant glioma
Abstract
Thermotherapy using magnetic nanoparticles is a new technique for interstitial hyperthermia and thermoablation based on magnetic field-induced excitation of biocompatible superparamagnetic nanoparticles. To evaluate the potential of this technique for minimally invasive treatment, we carried out a systematic analysis of its effects on experimental glioblastoma multiforme in a rat tumor model. Tumors were induced by implantation of RG-2-cells into the brains of 120 male Fisher rats. Animals were randomly allocated to 10 groups of 12 rats each, including controls. Animals received two thermotherapy treatments following a single intratumoral injection of two different magnetic fluids (dextran- or aminosilane-coated iron-oxide nanoparticles). Treatment was carried out on days four and six after tumor induction using an alternating magnetic field applicator system operating at a frequency of 100 kHz and variable field strength of 0-18 kA/m. The effectiveness of treatment was determined by the survival time of the animals and histopathological examinations of the brain and the tumor.Thermotherapy with aminosilane-coated nanoparticles led up to 4.5-fold prolongation of survival over controls, while the dextran-coated particles did not indicate any advantage. Intratumoral deposition of the aminosilane-coated particles was found to be stable, allowing for serial thermotherapy treatments without repeated injection. Histological and immunohistochemical examinations after treatment revealed large necrotic areas close to particle deposits, a decreased proliferation rate and a reactive astrogliosis adjacent to the tumor.Thus, localized interstitial thermotherapy with magnetic nanoparticles has an antitumoral effect on malignant brain tumors. This method is suitable for clinical use and may be a novel strategy for treating malignant glioma, which cannot be treated successfully today. The optimal treatment schedules and potential combinations with other therapies need to be defined in further studies.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
MRI cannot properly evaluate tumor progression after MFH because of artifacts from high SPION accumulation in the lesion.
“In addition, MRI for evaluation of tumor progression cannot be properly performed after MFH, because of the artifacts caused by the very high amounts of SPION that accumulate in the lesion [219].”
From Iron oxide nanoparticles: Diagnostic, therapeutic and theranostic applications (2019) · cites this paper as [219]
Cites
Radiotherapy Plus Concomitant and Adjuvant Temozolomide for Glioblastoma
Stupp, R., Mason, W. P., van den Bent, M. J., Weller, M., Fisher, B., Taphoorn, M. J. B., Belanger, K., Brandes, A. A., Marosi, C., Bogdahn, U., et al. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa043330 · Cited by 21,807 · see citing works
Hyperthermia in combined treatment of cancer
Wust, P., Hildebrandt, B., Sreenivasa, G., Rau, B., Gellermann, J., Riess, H. B., FELIX, R., & Schlag, P. (2002) · The Lancet Oncology · doi:10.1016/s1470-2045(02)00818-5 · Cited by 2,002 · see citing works
Self-citationThe cellular and molecular basis of hyperthermia
Hildebrandt, B. (2002) · Critical Reviews in Oncology/Hematology · doi:10.1016/s1040-8428(01)00179-2 · Cited by 1,714 · see citing works
Johannsen, M., Gneveckow, U., Eckelt, L., Feussner, A., Waldöfner, N., Scholz, R., Değer, S., Wust, P., Loening, S. A., & Jordan, A. (2005) · International Journal of Hyperthermia · doi:10.1080/02656730500158360 · Cited by 802 · see citing works
Self-citationJordan, A., Wust, P., Fählin, H., John, W., Hinz, A., & FELIX, R. (1993) · International Journal of Hyperthermia · doi:10.3109/02656739309061478 · Cited by 694 · see citing works
Self-citationMagnetically mediated hyperthermia: current status and future directions
Moroz, P., Jones, S. K., & Gray, B. N. (2002) · International Journal of Hyperthermia · doi:10.1080/02656730110108785 · Cited by 538 · see citing works
Jordan, A., Scholz, R., Wust, P., Schirra, H., Schiestel, T., Schmidt, H., & Felix, R. (1999) · Journal of Magnetism and Magnetic Materials · doi:10.1016/s0304-8853(98)00558-7 · Cited by 521 · see citing works
Self-citationBarth, R. F. (1998) · Journal of Neuro-Oncology · doi:10.1023/a:1005805203044 · Cited by 358 · see citing works
Effects of Magnetic Fluid Hyperthermia (MFH) on C3H mammary carcinomain vivo
Jordan, A., Scholz, R., Wust, P., Fähling, H., Krause, J., Wlodarczyk, W., Sander, B., Vogl, T., & FELIX, R. (1997) · International Journal of Hyperthermia · doi:10.3109/02656739709023559 · Cited by 325 · see citing works
Self-citationIntracellular Hyperthermia for Cancer Using Magnetite Cationic Liposomes: An in vivo Study
Yanase, M., Shinkai, M., Honda, H., Wakabayashi, T., Yoshida, J., & Kobayashi, T. (1998) · Japanese Journal of Cancer Research · doi:10.1111/j.1349-7006.1998.tb00586.x · Cited by 322 · see citing works
Jordan, A., Wust, P., Scholz, R., Tesche, B., Fähling, H., Mitrovics, T., Vogl, T., Cervós‐Navarro, J., & FELIX, R. (1996) · International Journal of Hyperthermia · doi:10.3109/02656739609027678 · Cited by 258 · see citing works
Self-citationThermal Ablation of Tumors Using Magnetic Nanoparticles
Hilger, I., Hiergeist, R., Hergt, R., Winnefeld, K., Schubert, H., & Kaiser, W. A. (2002) · Investigative Radiology · doi:10.1097/00004424-200210000-00008 · Cited by 224 · see citing works
Itô, A., Tanaka, K., Kondo, K., Shinkai, M., Honda, H., Matsumoto, K., Saida, T., & Kobayashi, T. (2003) · Cancer Science · doi:10.1111/j.1349-7006.2003.tb01438.x · Cited by 217 · see citing works
Johannsen, M., Thiesen, B., Jordan, A., Taymoorian, K., Gneveckow, U., Waldöfner, N., Scholz, R., Koch, M., Lein, M., Jung, K., et al. (2005) · The Prostate · doi:10.1002/pros.20213 · Cited by 198 · see citing works
Self-citationJohannsen, M., Thiesen, B., Gneveckow, U., Taymoorian, K., Waldöfner, N., Scholz, R., Değer, S., Jung, K., Loening, S. A., & Jordan, A. (2005) · The Prostate · doi:10.1002/pros.20324 · Cited by 123 · see citing works
Self-citationTanaka, K., Itô, A., Kobayashi, T., Kawamura, T., Shimada, S., Matsumoto, K., Saida, T., & Honda, H. (2005) · International Journal of Cancer · doi:10.1002/ijc.21061 · Cited by 122 · see citing works
Evaluation of Magnetic Fluid Hyperthermia in a Standard Rat Model of Prostate Cancer
Johannsen, M., Jordan, A., Scholz, R., Koch, M., Lein, M., Değer, S., Roigas, J., Jung, K., & Loening, S. A. (2004) · Journal of Endourology · doi:10.1089/0892779041271715 · Cited by 119 · see citing works
Self-citationKawai, N., Itô, A., Nakahara, Y., Futakuchi, M., Shirai, T., Honda, H., Kobayashi, T., & Kohri, K. (2005) · The Prostate · doi:10.1002/pros.20253 · Cited by 116 · see citing works
Devineni, D., Klein–Szanto, A. J., & Gallo, J. M. (1996) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s002800050518 · Cited by 56 · see citing works
Ohno, T., Wakabayashi, T., Takemura, A., Yoshida, J., Itô, A., Shinkai, M., Honda, H., & Kobayashi, T. (2002) · Journal of Neuro-Oncology · doi:10.1023/a:1015080808031 · Cited by 50 · see citing works
Aas, A. T., Brun, A. E., Blennow, C., Str�mblad, S., & Salford, L. G. (1995) · Journal of Neuro-Oncology · doi:10.1007/bf01059948 · Cited by 50 · see citing works
Radiation and drug response of the rat glioma RG2
Weizsäcker, M., Nagamune, A., Winkelströter, R., Vieten, H., & Wechsler, W. (1982) · European Journal of Cancer and Clinical Oncology · doi:10.1016/0277-5379(82)90200-0 · Cited by 22 · see citing works
Johannsen, M., Thiesen, B., Taymoorian, K., Gneveckow, U., Waldöfner, N., Koch, M., Scholz, R., Lein, M., Jung, K., Loening, S. A., et al. (2005) · European Urology Supplements · doi:10.1016/s1569-9056(05)80216-7 · Cited by 2 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Nanoparticles in Medicine: Therapeutic Applications and Developments
Zhang, L., Gu, F., Chan, J. M., Wang, A. Z., Langer, R., & Farokhzad, O. C. (2007) · Clinical Pharmacology & Therapeutics · doi:10.1038/sj.clpt.6100400 · Cited by 2,685 · see citing works
Reddy, L. H., Arias, J. L., Nicolas, J., & Couvreur, P. (2012) · Chemical Reviews · doi:10.1021/cr300068p · Cited by 2,106 · see citing works
Maier-Hauff, K., Ulrich, F., Nestler, D., Niehoff, H., Wust, P., Thiesen, B., Orawa, H., Budach, V., & Jordan, A. (2010) · Journal of Neuro-Oncology · doi:10.1007/s11060-010-0389-0 · Cited by 1,447 · see citing works
Self-citationRasmussen, J. W., Martinez, E., Louka, P., & Wingett, D. (2010) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2010.502560 · Cited by 1,346 · see citing works
Magnetic fluid hyperthermia: focus on superparamagnetic iron oxide nanoparticles
Laurent, S., Dutz, S., Häfeli, U. O., & Mahmoudi, M. (2011) · Advances in Colloid and Interface Science · doi:10.1016/j.cis.2011.04.003 · Cited by 1,326 · see citing works
Multifunctional Nanoparticles: Cost Versus Benefit of Adding Targeting and Imaging Capabilities
Cheng, Z., Zaki, A. A., Hui, J. Z., Muzykantov, V. R., & Tsourkas, A. (2012) · Science · doi:10.1126/science.1226338 · Cited by 1,322 · see citing works
Nanogels as Pharmaceutical Carriers: Finite Networks of Infinite Capabilities
Kabanov, A. V., & Vinogradov, S. V. (2009) · Angewandte Chemie International Edition · doi:10.1002/anie.200900441 · Cited by 1,320 · see citing works
Biological applications of magnetic nanoparticles
Colombo, M., Carregal‐Romero, S., Casula, M. F., Gutiérrez, L., Morales, M. P., Böhm, I., Heverhagen, J. T., Prosperi, D., & Parak, W. J. (2012) · Chemical Society Reviews · doi:10.1039/c2cs15337h · Cited by 1,314 · see citing works
Iron oxide nanoparticles: Diagnostic, therapeutic and theranostic applications
Dadfar, S. M., Roemhild, K., Drude, N. I., von Stillfried, S., Knüchel, R., Kiessling, F., & Lammers, T. (2019) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2019.01.005 · Cited by 1,181 · see citing works
Assessment of the Evolution of Cancer Treatment Therapies
Arruebo, M., Vilaboa, N. E., Sáez, B., Lambea, J., Tres, A., Valladares, M., & González‐Fernández, Á. (2011) · Cancers · doi:10.3390/cancers3033279 · Cited by 932 · see citing works
Clinical applications of magnetic nanoparticles for hyperthermia
Thiesen, B., & Jordan, A. (2008) · International Journal of Hyperthermia · doi:10.1080/02656730802104757 · Cited by 829 · see citing works
Self-citationMaier-Hauff, K., Rothe, R., Scholz, R., Gneveckow, U., Wust, P., Thiesen, B., Feussner, A., von Deimling, A., Waldöfner, N., Felix, R., et al. (2006) · Journal of Neuro-Oncology · doi:10.1007/s11060-006-9195-0 · Cited by 772 · see citing works
Self-citationTargeted pharmaceutical nanocarriers for cancer therapy and imaging
Torchilin, V. P. (2007) · The AAPS Journal · doi:10.1208/aapsj0902015 · Cited by 758 · see citing works
Surface Engineering of Iron Oxide Nanoparticles for Targeted Cancer Therapy
Kievit, F. M., & Zhang, M. (2011) · Accounts of Chemical Research · doi:10.1021/ar2000277 · Cited by 606 · see citing works
Nanooncology: The future of cancer diagnosis and therapy
Thakor, A. S., & Gambhir, S. S. (2013) · CA A Cancer Journal for Clinicians · doi:10.3322/caac.21199 · Cited by 591 · see citing works
Nanotechnology in hyperthermia cancer therapy: From fundamental principles to advanced applications
Beik, J., Abed, Z., Ghoreishi, F. S., Hosseini-Nami, S., Mehrzadi, S., Shakeri‐Zadeh, A., & Kamrava, S. K. (2016) · Journal of Controlled Release · doi:10.1016/j.jconrel.2016.05.062 · Cited by 581 · see citing works
Applications and potential toxicity of magnetic iron oxide nanoparticles
Liu, G., Gao, J., Ai, H., & Chen, X. (2013) · Small · doi:10.1002/smll.201201531 · Cited by 570 · see citing works
Johannsen, M., Gneveckow, U., Thiesen, B., Taymoorian, K., Cho, C. H., Waldöfner, N., Scholz, R., Jordan, A., Loening, S. A., & Wust, P. (2006) · European Urology · doi:10.1016/j.eururo.2006.11.023 · Cited by 531 · see citing works
Self-citationNanomaterials for Neural Interfaces
Kotov, N. A., Winter, J. O., Clements, I. P., Jan, E., Timko, B. P., Campidelli, S., Pathak, S., Mazzatenta, A., Lieber, C. M., Prato, M., et al. (2009) · Advanced Materials · doi:10.1002/adma.200801984 · Cited by 504 · see citing works
Kievit, F. M., & Zhang, M. (2011) · Advanced Materials · doi:10.1002/adma.201102313 · Cited by 495 · see citing works
Figuerola, A., Di Corato, R., Manna, L., & Pellegrino, T. (2010) · Pharmacological Research · doi:10.1016/j.phrs.2009.12.012 · Cited by 480 · see citing works
Magnetic nanoparticle hyperthermia for prostate cancer
Johannsen, M., Thiesen, B., Wust, P., & Jordan, A. (2010) · International Journal of Hyperthermia · doi:10.3109/02656731003745740 · Cited by 474 · see citing works
Self-citationTargeted magnetic iron oxide nanoparticles for tumor imaging and therapy
Shin, D. (2008) · International Journal of Nanomedicine · doi:10.2147/ijn.s2824 · Cited by 463 · see citing works
Magnetic Nanoparticles in Cancer Theranostics
Gobbo, O. L., Sjaastad, K., Radomski, M. W., Volkov, Y., & Prina‐Mello, A. (2015) · Theranostics · doi:10.7150/thno.11544 · Cited by 462 · see citing works
Tay, Z. W., Chandrasekharan, P., Chiu-Lam, A., Hensley, D. W., Dhavalikar, R., Zhou, X. Y., Yu, E. Y., Goodwill, P. W., Zheng, B., Rinaldi, C., et al. (2018) · ACS Nano · doi:10.1021/acsnano.8b00893 · Cited by 459 · see citing works
Kandasamy, G., & Maity, D. (2015) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2015.10.058 · Cited by 426 · see citing works
Aghebati‐Maleki, A., Dolati, S., Ahmadi, M., Baghbanzhadeh, A., Asadi, M., Fotouhi, A., Yousefi, M., & Maleki, L. A. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.29126 · Cited by 423 · see citing works
Hadjipanayis, C. G., Machaidze, R., Kaluzová, M., Wang, L., Schuette, A. J., Chen, H., Wu, X., & Mao, H. Z. (2010) · Cancer Research · doi:10.1158/0008-5472.can-10-1022 · Cited by 420 · see citing works
Mahmoudi, K., Bouras, A., Bozec, D., Ivkov, R., & Hadjipanayis, C. G. (2018) · International Journal of Hyperthermia · doi:10.1080/02656736.2018.1430867 · Cited by 417 · see citing works
Cancer therapy with iron oxide nanoparticles: Agents of thermal and immune therapies
Soetaert, F., Korangath, P. C., Serantes, D., Fiering, S., & Ivkov, R. (2020) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2020.06.025 · Cited by 413 · see citing works
Physics of heat generation using magnetic nanoparticles for hyperthermia
Dennis, C. L., & Ivkov, R. (2013) · International Journal of Hyperthermia · doi:10.3109/02656736.2013.836758 · Cited by 390 · see citing works
Nanoparticles for Radiation Therapy Enhancement: the Key Parameters
Retif, P., Pinel, S., Toussaint, M., Frochot, C., Chouikrat, R., Bastogne, T., & Barberi‐Heyob, M. (2015) · Theranostics · doi:10.7150/thno.11642 · Cited by 383 · see citing works
Post-mortem studies in glioblastoma patients treated with thermotherapy using magnetic nanoparticles
van Landeghem, F. K. H., Maier-Hauff, K., Jordan, A., Hoffmann, K., Gneveckow, U., Scholz, R., Thiesen, B., Brück, W., & von Deimling, A. (2008) · Biomaterials · doi:10.1016/j.biomaterials.2008.09.044 · Cited by 354 · see citing works
Self-citationMultifunctional nanoparticles for brain tumor imaging and therapy
Cheng, Y., Morshed, R. A., Auffinger, B., Tobias, A. L., & Lesniak, M. S. (2013) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2013.09.006 · Cited by 351 · see citing works
Health Concerns of Various Nanoparticles: A Review of Their in Vitro and in Vivo Toxicity
Ajdary, M., Moosavi, M. A., Rahmati, M., Falahati, M., Mahboubi, M., Mandegary, A., Jangjoo, S., Mohammadinejad, R., & Varma, R. S. (2018) · Nanomaterials · doi:10.3390/nano8090634 · Cited by 346 · see citing works
Horák, D., Babič, M., Macková, H., & Beneš, M. J. (2007) · Journal of Separation Science · doi:10.1002/jssc.200700088 · Cited by 342 · see citing works
EGFR-Targeted Magnetic Nanoparticle Heaters Kill Cancer Cells without a Perceptible Temperature Rise
Creixell, M., Bohórquez, A. C., Torres‐Lugo, M., & Rinaldi, C. (2011) · ACS Nano · doi:10.1021/nn201822b · Cited by 329 · see citing works
Nanoparticles: Functionalization and Multifunctional Applications in Biomedical Sciences
Subbiah, R., Veerapandian, M., & Yun, K. (2010) · Current Medicinal Chemistry · doi:10.2174/092986710794183024 · Cited by 326 · see citing works
McNamara, K., & Tofail, S. A. M. (2015) · Physical Chemistry Chemical Physics · doi:10.1039/c5cp00831j · Cited by 312 · see citing works
Cole, A. J., David, A. E., Wang, J., Galbán, C. J., Hill, H. L., & Yang, V. C. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2010.11.040 · Cited by 308 · see citing works
Alphandéry, E., Faure, S., Seksek, O., Guyot, F., & Chebbi, I. (2011) · ACS Nano · doi:10.1021/nn201290k · Cited by 306 · see citing works
Gamarra, L. F., Silva, A. C., de Oliveira, T. R., Mamani, J. B., Malheiros, S. M. F., Malavolta, L., Pavon, L. F., Sibov, T. T., Amaro, E., & Gamarra, L. F. (2011) · International Journal of Nanomedicine · doi:10.2147/ijn.s14737 · Cited by 298 · see citing works
Wust, P., Gneveckow, U., Wust, P., Gneveckow, U., Johannsen, M., Böhmer, D., Henkel, T. O., Kahmann, F., Sehouli, J., FELIX, R., et al. (2006) · International Journal of Hyperthermia · doi:10.1080/02656730601106037 · Cited by 295 · see citing works
Self-citationDrug loaded magnetic nanoparticles for cancer therapy
Jurgons, R., Seliger, C., Hilpert, A., Trahms, L., Odenbach, S., & Alexiou, C. (2006) · Journal of Physics Condensed Matter · doi:10.1088/0953-8984/18/38/s24 · Cited by 282 · see citing works
Espinosa, A., Kolosnjaj‐Tabi, J., Abou‐Hassan, A., Sangnier, A. P., Curcio, A., Silva, A., Corato, R. D., Neveu, S., Pellegrino, T., Liz‐Marzán, L. M., et al. (2018) · Advanced Functional Materials · doi:10.1002/adfm.201803660 · Cited by 271 · see citing works
Magnetic fluid hyperthermia: Advances, challenges, and opportunity
Kozissnik, B., Bohórquez, A. C., Dobson, J., & Rinaldi, C. (2013) · International Journal of Hyperthermia · doi:10.3109/02656736.2013.837200 · Cited by 267 · see citing works
Inorganic nanomaterials for bioimaging, targeted drug delivery and therapeutics
Liang, R., Wei, M., Evans, D. G., & Duan, X. (2014) · Chemical Communications · doi:10.1039/c4cc03118k · Cited by 263 · see citing works
Nanoparticles for Thermal Cancer Therapy
Day, E. S., Morton, J. G., & West, J. L. (2009) · Journal of Biomechanical Engineering · doi:10.1115/1.3156800 · Cited by 263 · see citing works
Lartigue, L., Innocenti, C., Thangavel, K., Awwad, A., Duque, M. D. M. S., Guari≠, Y., Larionova≠, J., Guérin, C., Montero, J., Barragan‐Montero, V., et al. (2011) · Journal of the American Chemical Society · doi:10.1021/ja111448t · Cited by 260 · see citing works
Optimizing Magnetic Nanoparticle Design for Nanothermotherapy
Gazeau, F., Lévy, M., & Wilhelm, C. (2008) · Nanomedicine · doi:10.2217/17435889.3.6.831 · Cited by 256 · see citing works
Magnetic iron oxide nanoparticles for brain imaging and drug delivery
Qiao, R., Fu, C., Forgham, H., Javed, I., Huang, X., Zhu, J., Whittaker, A. K., & Davis, T. P. (2023) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2023.114822 · Cited by 254 · see citing works
SHARMA, H. S., & Sharma, A. (2007) · Progress in brain research · doi:10.1016/s0079-6123(06)62013-x · Cited by 246 · see citing works
Balivada, S., Rachakatla, R. S., Wang, H., Samarakoon, T., Dani, R. K., Pyle, M. M., Kroh, F. O., Walker, B., Leaym, X., Koper, O., et al. (2010) · BMC Cancer · doi:10.1186/1471-2407-10-119 · Cited by 236 · see citing works
Structural Investigation of MFe2O4 (M = Fe, Co) Magnetic Fluids
Jacintho, G. V. M., Brolo, A. G., Cório, P., Suarez, P. A. Z., & Rubim, J. C. (2009) · The Journal of Physical Chemistry C · doi:10.1021/jp9013477 · Cited by 231 · see citing works
Palanisamy, S., & Wang, Y.-M. (2019) · Dalton Transactions · doi:10.1039/c9dt00459a · Cited by 230 · see citing works
Salloum, M., Ma, R., Weeks, D., & Zhu, L. K. (2008) · International Journal of Hyperthermia · doi:10.1080/02656730801907937 · Cited by 226 · see citing works
Magnetic nanofluids (Ferrofluids): Recent advances, applications, challenges, and future directions
Philip, J. (2022) · Advances in Colloid and Interface Science · doi:10.1016/j.cis.2022.102810 · Cited by 225 · see citing works
Zhang, L., Dong, W., & Sun, H. (2013) · Nanoscale · doi:10.1039/c3nr01616a · Cited by 214 · see citing works
Review on magnetic nanoparticle-mediated hyperthermia for cancer therapy
Arunima Rajan, S., & Sahu, N. K. (2020) · Journal of Nanoparticle Research · doi:10.1007/s11051-020-05045-9 · Cited by 205 · see citing works
Grauer, O. M., Jaber, M., Heß, K., Weckesser, M., Schwindt, W., Maring, S., Wölfer, J., & Stummer, W. (2018) · Journal of Neuro-Oncology · doi:10.1007/s11060-018-03005-x · Cited by 186 · see citing works
Magnetic Hyperthermia and Radiation Therapy: Radiobiological Principles and Current Practice †
Spirou, S. V., Basini, M., Lascialfari, A., Sangregorio, C., & Innocenti, C. (2018) · Nanomaterials · doi:10.3390/nano8060401 · Cited by 179 · see citing works
Electrospun Nanofibers: Recent Applications in Drug Delivery and Cancer Therapy
Contreras‐Cáceres, R., Cabeza, L., Perazzoli, G., Díaz, A., López‐Romero, J. M., Melguizo, C., & Prados, J. C. (2019) · Nanomaterials · doi:10.3390/nano9040656 · Cited by 173 · see citing works
Nanotechnology based approaches in cancer therapeutics
Biswas, A. K., Islam, M. R., Choudhury, Z. S., Mostafa, A., & Kadir, M. F. (2014) · Advances in Natural Sciences Nanoscience and Nanotechnology · doi:10.1088/2043-6262/5/4/043001 · Cited by 163 · see citing works
Iron and manganese based magnetocaloric materials for near room temperature thermal management
Chaudhary, V., Chen, X., & Ramanujan, R. V. (2018) · Progress in Materials Science · doi:10.1016/j.pmatsci.2018.09.005 · Cited by 161 · see citing works
Combining magnetic particle imaging and magnetic fluid hyperthermia in a theranostic platform
Hensley, D. W., Tay, Z. W., Dhavalikar, R., Zheng, B., Goodwill, P. W., Rinaldi, C., & Conolly, S. (2016) · Physics in Medicine and Biology · doi:10.1088/1361-6560/aa5601 · Cited by 149 · see citing works
Nanoshell-mediated photothermal therapy improves survival in a murine glioma model
Day, E. S., Thompson, P. A., Zhang, L., Lewinski, N. A., Ahmed, N. M., Drezek, R. A., Blaney, S. M., & West, J. L. (2010) · Journal of Neuro-Oncology · doi:10.1007/s11060-010-0470-8 · Cited by 148 · see citing works
Ittrich, H., Peldschus, K., Raabe, N., Kaul, M. G., & Adam, G. (2013) · RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren · doi:10.1055/s-0033-1335438 · Cited by 143 · see citing works
Zhang, Y., Zhai, D., Xu, M., Yao, Q., Chang, J., & Wu, C. (2016) · Journal of Materials Chemistry B · doi:10.1039/c6tb00390g · Cited by 141 · see citing works
Magnetic nanoparticles: an emerging technology for malignant brain tumor imaging and therapy
Wankhede, M., Bouras, A., Kaluzová, M., & Hadjipanayis, C. G. (2012) · Expert Review of Clinical Pharmacology · doi:10.1586/ecp.12.1 · Cited by 138 · see citing works
Applications of Nanoparticles for MRI Cancer Diagnosis and Therapy
Błasiak, B., van Veggel, F. C. J. M., & Tomanek, B. (2013) · Journal of Nanomaterials · doi:10.1155/2013/148578 · Cited by 138 · see citing works
Basel, M. T., Balivada, S., Wang, Shrestha, Seo, Pyle, Ayabaweera, Dani, R. K., Koper, Tamura, M., et al. (2012) · International Journal of Nanomedicine · doi:10.2147/ijn.s28344 · Cited by 137 · see citing works
Magnetic Nanoparticle Targeted Hyperthermia of Cutaneous Staphylococcus aureus Infection
Kim, M.-H., Yamayoshi, I., Mathew, S., Lin, H., Nayfach, J., & Simon, S. I. (2013) · Annals of Biomedical Engineering · doi:10.1007/s10439-012-0698-x · Cited by 135 · see citing works
Hernández-Hernandez, A. A., Aguirre‐Álvarez, G., Cariño‐Cortés, R., Mendoza-Huízar, L. H., & Jiménez-Alvarado, R. (2020) · Chemical Papers · doi:10.1007/s11696-020-01229-8 · Cited by 135 · see citing works
Nanoparticles for Imaging and Treating Brain Cancer
Meyers, J. D., Doane, T. L., Burda, C., & Basilion, J. P. (2012) · Nanomedicine · doi:10.2217/nnm.12.185 · Cited by 130 · see citing works
Superparamagnetic iron oxide nanoparticles: promises for diagnosis and treatment of cancer.
Laurent, S., & Mahmoudi, M. (2011) · PubMed Central · Cited by 130 · see citing works
Etemadi, H., & Plieger, P. G. (2020) · Advanced Therapeutics · doi:10.1002/adtp.202000061 · Cited by 130 · see citing works
Soleymani, M., Velashjerdi, M., Shaterabadi, Z., & Barati, A. (2020) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2020.116130 · Cited by 128 · see citing works
Nanoparticles for hyperthermic therapy: synthesis strategies and applications in glioblastoma
Lal, S., Verma, J., & Noorden, C. J. F. V. (2014) · International Journal of Nanomedicine · doi:10.2147/ijn.s57501 · Cited by 127 · see citing works
Magnetic Nanoparticles: From Synthesis to Theranostic Applications
Khizar, S., Ahmad, N. M., Zine, N., Jaffrezic-Renault, N. J., Errachid, A., & Elaı̈ssari, A. (2021) · ACS Applied Nano Materials · doi:10.1021/acsanm.1c00852 · Cited by 127 · see citing works
Magnetic mesoporous silica spheres for hyperthermia therapy
Martín-Saavedra, F. M., Ruíz-Hernández, E., Boré, A., Arcos, D., Vallet‐Regí, M., & Vilaboa, N. E. (2010) · Acta Biomaterialia · doi:10.1016/j.actbio.2010.06.030 · Cited by 126 · see citing works
Magnetic nanoparticles and nanocomposites for remote controlled therapies
Hauser, A. K., Wydra, R. J., Stocke, N. A., Anderson, K. W., & Hilt, J. Z. (2015) · Journal of Controlled Release · doi:10.1016/j.jconrel.2015.09.039 · Cited by 125 · see citing works
Treatment of Canine Oral Melanoma with Nanotechnology-Based Immunotherapy and Radiation
Hoopes, P. J., Wagner, R. J., Duval, K. E. A., Kang, K., Gladstone, D. J., Moodie, K. L., Crary-Burney, M., Arias‐Pulido, H., Veliz, F. A., Steinmetz, N. F., et al. (2018) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.8b00126 · Cited by 125 · see citing works
Therapeutic Nanomedicine for Brain Cancer
Tzeng, S. Y., & Green, J. J. (2013) · Therapeutic Delivery · doi:10.4155/tde.13.38 · Cited by 123 · see citing works
Processing of Iron Oxide Nanoparticles by Supercritical Fluids
Lam, U. T., Mammucari, R., Suzuki, K., & Foster, N. R. (2008) · Industrial & Engineering Chemistry Research · doi:10.1021/ie070494+ · Cited by 122 · see citing works
Chelate-free metal ion binding and heat-induced radiolabeling of iron oxide nanoparticles
Boros, E., Bowen, A. M., Josephson, L., Vasdev, N., & Holland, J. P. (2014) · Chemical Science · doi:10.1039/c4sc02778g · Cited by 121 · see citing works
Enhanced reduction in cell viability by hyperthermia induced by magnetic nanoparticles
Torres‐Lugo, M., Rodriguez, H. L., Latorre‐Esteves, M., Méndez, J., Soto, O., Rodriguez, A. R., & Rinaldi, C. (2011) · International Journal of Nanomedicine · doi:10.2147/ijn.s14613 · Cited by 120 · see citing works
Nanoparticles: Novel vehicles in treatment of Glioblastoma
Pourgholi, F., Hajivalili, M., Jadidi‐Niaragh, F., Kafil, H. S., & Yousefi, M. (2015) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2015.12.014 · Cited by 120 · see citing works
Application of iron oxide nanoparticles in glioma imaging and therapy: from bench to bedside
Liu, H., Zhang, J., Chen, X., Du, X., Zhang, J., Liu, G., & Zhang, W. (2016) · Nanoscale · doi:10.1039/c6nr00147e · Cited by 120 · see citing works
A review on hyperthermia via nanoparticle-mediated therapy
Sohail, A., Ahmad, Z., Bég, O. A., Arshad, S., & Sherin, L. (2017) · Bulletin du Cancer · doi:10.1016/j.bulcan.2017.02.003 · Cited by 119 · see citing works
Fèvre, R. L., Durand‐Dubief, M., Chebbi, I., Mandawala, C., Lagroix, F., Valet, J., Idbaïh, A., Adam, C., Delattre, J., Schmitt, C., et al. (2017) · Theranostics · doi:10.7150/thno.18927 · Cited by 118 · see citing works
Dante, S., Petrelli, A., Petrini, E. M., Marotta, R., Maccione, A., Alabastri, A., Quarta, A., Donato, F. D., Ravasenga, T., Sathya, A., et al. (2017) · ACS Nano · doi:10.1021/acsnano.7b00397 · Cited by 117 · see citing works
Salloum, M., Ma, R., & Zhu, L. K. (2008) · International Journal of Hyperthermia · doi:10.1080/02656730802203377 · Cited by 117 · see citing works
Proposal of New Safety Limits for In Vivo Experiments of Magnetic Hyperthermia Antitumor Therapy
de la Parte, B. H., Rodrigo, I., Gutiérrez-Basoa, J., Correcher, S. I., Medina, C. M., Echevarría-Uraga, J. J., García, J. Á., Plazaola, F., & Garcı́a-Alonso, I. (2022) · Cancers · doi:10.3390/cancers14133084 · Cited by 116 · see citing works
Magnetoliposomes: Versatile Innovative Nanocolloids for Use in Biotechnology and Biomedicine
Soenen, S. J., Hodenius, M., & Cuyper, M. D. (2009) · Nanomedicine · doi:10.2217/17435889.4.2.177 · Cited by 113 · see citing works
Effective Elimination of Cancer Stem Cells by Magnetic Hyperthermia
Sadhukha, T., Niu, L., Wiedmann, T. S., & Panyam, J. (2013) · Molecular Pharmaceutics · doi:10.1021/mp400015b · Cited by 112 · see citing works
Nanoparticle-Based Therapies for Wound Biofilm Infection: Opportunities and Challenges
Kim, M. (2016) · IEEE Transactions on NanoBioscience · doi:10.1109/tnb.2016.2527600 · Cited by 112 · see citing works
Use of bacterial magnetosomes in the magnetic hyperthermia treatment of tumours: A review
Alphandéry, E., Chebbi, I., Guyot, F., & Durand‐Dubief, M. (2013) · International Journal of Hyperthermia · doi:10.3109/02656736.2013.821527 · Cited by 110 · see citing works
NanoFerrite Particle Based Radioimmunonanoparticles: Binding Affinity and In Vivo Pharmacokinetics
Natarajan, A., Gruettner, C., Ivkov, R., DeNardo, G. L., Mirick, G. R., Yuan, A., Foreman, A. R., & DeNardo, S. J. (2008) · Bioconjugate Chemistry · doi:10.1021/bc800015n · Cited by 110 · see citing works
Cancer therapy using nanoformulated substances: scientific, regulatory and financial aspects
Alphandéry, E., Grand-Dewyse, P., Lefèvre, R., Mandawala, C., & Durand‐Dubief, M. (2015) · Expert Review of Anticancer Therapy · doi:10.1586/14737140.2015.1086647 · Cited by 108 · see citing works
Synthesis of composite magnetic nanoparticles Fe3O4 with alendronate for osteoporosis treatment
Lee, M. S., Su, C.-M., Yeh, J., Wu, P., Tsai, T., & Lou, S.-L. (2016) · International Journal of Nanomedicine · doi:10.2147/ijn.s112415 · Cited by 108 · see citing works
- Authors
- Jordan, A., Scholz, R., Maier-Hauff, K., van Landeghem, F. K. H., Waldoefner, N., Teichgraeber, U., Pinkernelle, J., Bruhn, H., Neumann, F., Thiesen, B., von Deimling, A., & Felix, R.
- Affiliations
- Charité – Universitätsmedizin Berlin (DE)
- Corresponding author
- Jordan, Andreas
- ORCID
- Bruhn, Harald
- Venue
- Journal of Neuro-Oncology
- Published
- 2005-11-29
- Volume
- 78
- Issue
- 1
- Pages
- 7-14
- ISSN
- 0167-594X (ISSN-L)
- 1573-7373
- OpenAlex
- W2093807603
- Cited by
- 459
- References
- 23
- Citations by year
- 2026: 5 · 2025: 10 · 2024: 11 · 2023: 17 · 2022: 19 · 2021: 30 · 2020: 23 · 2019: 20 · 2018: 31 · 2017: 30 · 2016: 20 · 2015: 28 · 2014: 32 · 2013: 29 · 2012: 28
- FWCI
- 10.36
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Journal of Neuro-Oncology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- European Regional Development Fund
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Characterization and Applications of Magnetic Nanoparticles
- Physical Sciences › Engineering › Biomedical Engineering › Ultrasound and Hyperthermia Applications
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Keywords
- magnetic nanoparticles, heat therapy, glioblastoma, high-grade glioma, interstitial hyperthermia, thermal ablation, superparamagnetic iron oxide nanoparticles, dextran-coated nanoparticles, alternating magnetic field, intratumoral injection, tumor necrosis, astrocyte activation, rat tumor model, survival
- MeSH terms
- Animals, Brain Neoplasms, Glioma, Hyperthermia, Induced, Immunohistochemistry, Magnetic Resonance Imaging, Magnetics, Male, Rats, Inbred F344, Survival Analysis, Nanostructures, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
