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Chemiluminescence and Chemiluminescence Resonance Energy Transfer (CRET) Aptamer Sensors Using Catalytic Hemin/G-Quadruplexes
Open accessAbstract
The incorporation of hemin into the thrombin/G-quadruplex aptamer assembly or into the ATP/G-quadruplex nanostructure yields active DNAzymes that catalyze the generation of chemiluminescence. These catalytic processes enable the detection of thrombin and ATP with detection limits corresponding to 200 pM and 10 μM, respectively. The conjugation of the antithrombin or anti-ATP aptamers to CdSe/ZnS semiconductor quantum dots (QDs) allowed the detection of thrombin or ATP through the luminescence of the QDs that is powered by a chemiluminescence resonance energy-transfer (CRET) process stimulated by the hemin/G-quadruplex/thrombin complex or the hemin/G-quadruplex/ATP nanostructure, in the presence of luminol/H(2)O(2). The advantages of applying the CRET process for the detection of thrombin or ATP, by the resulting hemin/G-quadruplex DNAzyme structures, are reflected by low background signals and the possibility to develop multiplexed aptasensor assays using different sized QDs.
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Citations
Cited by
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Triplex DNA Nanostructures: From Basic Properties to Applications
Hu, Y., Cecconello, A., Idili, A., Ricci, F., & Willner, I. (2017) · Angewandte Chemie International Edition · doi:10.1002/anie.201701868 · Cited by 336
Self-citationOptical aptasensors for quantitative detection of small biomolecules: A review
Feng, C., Dai, S., & Wang, L. (2014) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2014.03.014 · Cited by 300
Recent advances in nanoparticle based aptasensors for food contaminants
Sharma, R., Ragavan, K. V., Thakur, M. S., & Raghavarao, K. S. M. S. (2015) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2015.07.017 · Cited by 258
A general approach to the design of allosteric, transcription factor-regulated DNAzymes
Adornetto, G., Porchetta, A., Palleschi, G., Plaxco, K. W., & Ricci, F. (2015) · Chemical Science · doi:10.1039/c5sc00228a · Cited by 31
Metadata
- Authors
- Liu, X., Freeman, R., Golub, E., & Willner, I.
- Venue
- ACS Nano
- Publisher
- American Chemical Society (ACS)
- Published
- 2011-09-08
- Volume
- 5
- Issue
- 9
- Pages
- 7648-7655
- ISSN
- 1936-0851 (ISSN-L)
- 1936-086X
- OpenAlex
- W2330004524
- Cited by
- 274
- References
- 0
- FWCI
- 12.58
- Type
- journal article
- Language
- en
- Open access
- green
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