The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Organic Stealth Nanoparticles for Highly Effective in Vivo Near-Infrared Photothermal Therapy of Cancer
Abstract
In recent years, a wide range of near-infrared (NIR) light absorbing nanomaterials, mostly inorganic ones, have been developed for photothermal therapy (PTT) of cancer. In this work, we develop a novel organic PTT agent based on poly-(3,4-ethylenedioxythiophene):poly(4-styrenesulfonate) (PEDOT:PSS), a conductive polymer mixture with strong NIR absorbance, for in vivo photothermal treatment of cancer. After being layer-by-layer coated with charged polymers and then conjugated with branched polyethylene glycol (PEG), the obtained PEDOT:PSS-PEG nanoparticles are highly stable in the physiological environment and exhibit a stealth-like behavior after intravenous injection with a long blood circulation half-life. As a result, an extremely high in vivo tumor uptake of PEDOT:PSS-PEG attributed to the tumor-enhanced permeability and retention effect is observed. We further use PEDOT:PSS-PEG as a PTT agent for in vivo cancer treatment and realize excellent therapeutic efficacy in a mouse tumor model under NIR light irradiation at a low laser power density. Comprehensive blood tests and careful histological examination reveal no apparent toxicity of PEDOT:PSS-PEG to mice at our treated dose within 40 days. To our best knowledge, this work is the first to use systemically administrated conductive polymer nanoparticles for highly effective in vivo PTT treatment in animals and encourages further explorations of those organic nanomaterials for cancer theranostic applications.
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Cites
Freestanding palladium nanosheets with plasmonic and catalytic properties
Huang, X., Tang, S., Mu, X., Dai, Y., Chen, G., Zhou, Z., Ruan, F., Yang, Z., & Zheng, N. (2011) · Nature Nanotechnology · doi:10.1038/nnano.2010.235 · Cited by 1,602
Sharifi, S., Behzadi, S., Laurent, S., Laird Forrest, M., Stroeve, P., & Mahmoudi, M. (2012) · Chem. Soc. Rev. · doi:10.1039/c1cs15188f · Cited by 1,460
Cited by
Nano-graphene in biomedicine: theranostic applications
Yang, K., Feng, L., Shi, X., & Liu, Z. (2013) · Chem. Soc. Rev. · doi:10.1039/c2cs35342c · Cited by 1,634
Self-citationMaterials for solar-powered water evaporation
Zhao, F., Guo, Y., Zhou, X., Shi, W., & Yu, G. (2020) · Nature Reviews Materials · doi:10.1038/s41578-020-0182-4 · Cited by 1,541
Zha, Z., Yue, X., Ren, Q., & Dai, Z. (2013) · Advanced Materials · doi:10.1002/adma.201202211 · Cited by 746
Song, G., Liang, C., Yi, X., Zhao, Q., Cheng, L., Yang, K., & Liu, Z. (2016) · Advanced Materials · doi:10.1002/adma.201504617 · Cited by 587
Self-citationXiao, Q., Zheng, X., Bu, W., Ge, W., Zhang, S., Chen, F., Xing, H., Ren, Q., Fan, W., Zhao, K., et al. (2013) · Journal of the American Chemical Society · doi:10.1021/ja404985w · Cited by 554
Metadata
- Authors
- Cheng, L., Yang, K., Chen, Q., & Liu, Z.
- Venue
- ACS Nano
- Publisher
- American Chemical Society (ACS)
- Published
- 2012-05-22
- Volume
- 6
- Issue
- 6
- Pages
- 5605-5613
- ISSN
- 1936-0851 (ISSN-L)
- 1936-086X
- OpenAlex
- W2001903221
- Cited by
- 429
- References
- 2
- FWCI
- 20.75
- Type
- journal article
- Language
- en
- Open access
- closed
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