The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Aptamer-Functionalized Nanoparticles for Medical Applications: Challenges and Opportunities
Open accessAbstract
With advances in aptamer selection technologies and nanomedicine, aptamer-functionalized nanoparticles are being explored as promising platforms for targeted therapeutic and diagnostic applications. In this Perspective, we outline recent progress in this field, as exemplified by Bamrungsap et al. in this issue of ACS Nano. Furthermore, we highlight the challenges and opportunities in translating current proof-of-concept designs into in vivo applications, with emphasis on the intrinsic properties of aptamers and their interplay with nanoparticles. With continuous efforts, we expect aptamer-functionalized nanoparticles to advance from preclinical into clinical development for further evaluation.
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Cites
Cancer nanotechnology: opportunities and challenges
Ferrari, M. (2005) · Nature Reviews Cancer · doi:10.1038/nrc1566 · Cited by 4,558
Nanoparticle therapeutics: an emerging treatment modality for cancer
Davis, M. E., Chen, Z., & Shin, D. M. (2008) · Nature Reviews Drug Discovery · doi:10.1038/nrd2614 · Cited by 4,233
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Nanomedicine therapeutic approaches to overcome cancer drug resistance
Markman, J. L., Rekechenetskiy, A., Holler, E., & Ljubimova, J. Y. (2013) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2013.09.019 · Cited by 733
“Currently, all nanoparticles using aptamers as target agents are still in the preclinical phase [103].”
BackgroundPeptide ligand-mediated targeted drug delivery of nanomedicines
Jiang, Z., Guan, J., Qian, J., & Zhan, C. (2019) · Biomaterials Science · doi:10.1039/c8bm01340c · Cited by 172
Nexus between in silico and in vivo models to enhance clinical translation of nanomedicine
Moradi Kashkooli, F., Soltani, M., Souri, M., Meaney, C., & Kohandel, M. (2021) · Nano Today · doi:10.1016/j.nantod.2020.101057 · Cited by 120
Tang, Z., Zhang, L., Wang, Y., Li, D., Zhong, Z., & Zhou, S. (2016) · Acta Biomaterialia · doi:10.1016/j.actbio.2016.06.038 · Cited by 73
Metadata
- Authors
- Xiao, Z., & Farokhzad, O. C.
- Venue
- ACS Nano
- Publisher
- American Chemical Society (ACS)
- Published
- 2012-05-10
- Volume
- 6
- Issue
- 5
- Pages
- 3670-3676
- ISSN
- 1936-0851 (ISSN-L)
- 1936-086X
- OpenAlex
- W2051580523
- Cited by
- 172
- References
- 2
- FWCI
- 6.97
- Type
- journal article
- Language
- en
- Open access
- green
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- Xiao, Z., & Farokhzad, O. C. (2012). Aptamer-Functionalized Nanoparticles for Medical Applications: Challenges and Opportunities. ACS Nano. https://doi.org/10.1021/nn301869z
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