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RGD-Modified Apoferritin Nanoparticles for Efficient Drug Delivery to Tumors
Open accessAbstract
Ferritin (FRT) is a major iron storage protein found in humans and most living organisms. Each ferritin is composed of 24 subunits, which self-assemble to form a cage-like nanostructure. FRT nanocages can be genetically modified to present a peptide sequence on the surface. Recently, we demonstrated that Cys-Asp-Cys-Arg-Gly-Asp-Cys-Phe-Cys (RGD4C)-modified ferritin can efficiently home to tumors through RGD-integrin αvβ3 interaction. Though promising, studies on evaluating surface modified ferritin nanocages as drug delivery vehicles have seldom been reported. Herein, we showed that after being precomplexed with Cu(II), doxorubicin can be loaded onto RGD modified apoferritin nanocages with high efficiency (up to 73.49 wt %). When studied on U87MG subcutaneous tumor models, these doxorubicin-loaded ferritin nanocages showed a longer circulation half-life, higher tumor uptake, better tumor growth inhibition, and less cardiotoxicity than free doxorubicin. Such a technology might be extended to load a broad range of therapeutics and holds great potential in clinical translation.
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Cited by
Liang, M., Fan, K., Zhou, M., Duan, D., Zheng, J., Yang, D., Feng, J., & Yan, X. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1407808111 · Cited by 507
Recent Advances in Subcellular Targeted Cancer Therapy Based on Functional Materials
Chen, W., Luo, G., & Zhang, X. (2019) · Advanced Materials · doi:10.1002/adma.201802725 · Cited by 373
pH-Sensitive ZnO Quantum Dots–Doxorubicin Nanoparticles for Lung Cancer Targeted Drug Delivery
Cai, X., Luo, Y., Zhang, W., Du, D., & Lin, Y. (2016) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.6b04933 · Cited by 359
Chen, F., Ehlerding, E. B., & Cai, W. (2014) · Journal of Nuclear Medicine · doi:10.2967/jnumed.114.146019 · Cited by 328
Passive versus Active Tumor Targeting Using RGD- and NGR-Modified Polymeric Nanomedicines
Kunjachan, S., Pola, R., Gremse, F., Theek, B., Ehling, J., Moeckel, D., Hermanns-Sachweh, B., Pechar, M., Ulbrich, K., Hennink, W. E., et al. (2014) · Nano Letters · doi:10.1021/nl404391r · Cited by 317
Metadata
- Authors
- Zhen, Z., Tang, W., Chen, H., Lin, X., Todd, T., Wang, G., Cowger, T., Chen, X., & Xie, J.
- Venue
- ACS Nano
- Publisher
- American Chemical Society (ACS)
- Published
- 2013-06-04
- Volume
- 7
- Issue
- 6
- Pages
- 4830-4837
- ISSN
- 1936-0851 (ISSN-L)
- 1936-086X
- OpenAlex
- W2087782895
- Cited by
- 368
- References
- 0
- FWCI
- 11.62
- Type
- journal article
- Language
- en
- Open access
- green
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- Zhen, Z., Tang, W., Chen, H., Lin, X., Todd, T., Wang, G., Cowger, T., Chen, X., & Xie, J. (2013). RGD-Modified Apoferritin Nanoparticles for Efficient Drug Delivery to Tumors. ACS Nano. https://doi.org/10.1021/nn305791q
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