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pH-Sensitive ZnO Quantum Dots–Doxorubicin Nanoparticles for Lung Cancer Targeted Drug Delivery
Abstract
In this paper, we reported a ZnO quantum dots-based pH-responsive drug delivery platform for intracellular controlled release of drugs. Acid-decomposable, luminescent aminated ZnO quantum dots (QDs) were synthesized as nanocarriers with ultrasmall size (∼3 nm). The dicarboxyl-terminated poly(ethylene glycol) (PEG) had been introduced to NH2-ZnO QDs, which rendered it stable under physiological fluid. Moreover, a targeting ligand, hyaluronic acid (HA), was conjugated to ZnO QDs for specifically binding to the overexpressed glycoprotein CD44 by cancer cells. Doxorubicin (DOX) molecules were successfully loaded to PEG functionalized ZnO QDs via formation of metal-DOX complex and covalent interactions. The pH-sensitive ZnO QDs dissolved to Zn(2+) in acidic endosome/lysosome after uptake by cancer cells, which triggered dissociation of the metal-drug complex and a controlled DOX release. As result, a synergistic therapy was achieved due to incorporation of the antitumor effect of Zn(2+) and DOX.
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Cited by
Quantum dots in imaging, drug delivery and sensor applications
Matea, C., Mocan, T., Tabaran, F., Pop, T., Mosteanu, O., Puia, C., Iancu, C., & Mocan, L. (2017) · International Journal of Nanomedicine · doi:10.2147/ijn.s138624 · Cited by 666
Internal stimuli-responsive nanocarriers for drug delivery: Design strategies and applications
Liu, M., Du, H., Zhang, W., & Zhai, G. (2017) · Materials Science and Engineering: C · doi:10.1016/j.msec.2016.11.030 · Cited by 235
Self-citationNanoparticle Interactions with the Tumor Microenvironment
Huai, Y., Hossen, M. N., Wilhelm, S., Bhattacharya, R., & Mukherjee, P. (2019) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.9b00448 · Cited by 113
Maxwell, T., Nogueira Campos, M. G., Smith, S., Doomra, M., Thwin, Z., & Santra, S. (2020) · Nanoparticles for Biomedical Applications · doi:10.1016/b978-0-12-816662-8.00015-1 · Cited by 43
Metadata
- Authors
- Cai, X., Luo, Y., Zhang, W., Du, D., & Lin, Y.
- Venue
- ACS Applied Materials & Interfaces
- Publisher
- American Chemical Society (ACS)
- Published
- 2016-08-19
- Volume
- 8
- Issue
- 34
- Pages
- 22442-22450
- ISSN
- 1944-8244 (ISSN-L)
- 1944-8252
- OpenAlex
- W2490849378
- Cited by
- 359
- References
- 0
- FWCI
- 12.03
- Type
- journal article
- Language
- en
- Open access
- closed
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- Cai, X., Luo, Y., Zhang, W., Du, D., & Lin, Y. (2016). pH-Sensitive ZnO Quantum Dots–Doxorubicin Nanoparticles for Lung Cancer Targeted Drug Delivery. ACS Applied Materials & Interfaces. https://doi.org/10.1021/acsami.6b04933
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