The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Self-Assembled Tat Nanofibers as Effective Drug Carrier and Transporter
Open accessAbstract
Cell penetrating peptides (CPPs) have been extensively explored as molecular vectors through covalent linkage to anticancer drugs to improve the drug's water solubility and to help overcome multidrug resistance. We report here the use of the Tat CPP as a molecular building unit to construct well-defined supramolecular nanofibers that can be utilized as a nanoscale vector to encapsulate the hydrophobic drug paclitaxel (PTX) (loading efficiency: 89.7 ± 5.0%) with a high loading capacity (6.8 ± 0.4%). Notably, our TEM imaging results reveal that nanofibers containing a higher PTX content tend to be more flexible than those with a lower PTX content. Fluorescence and confocal microscopy imaging show that the Tat nanofibers can effectively transport encapsulated molecules into the cells through an adsorptive-mediated endocytosis pathway. Cytotoxicity experiments and flow cytometry measurements demonstrate that PTX loaded in the nanofibers exerts its cytotoxicity against cancer cells by arresting the cells at the G2/M phase, the same working mechanism as free PTX.
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Cites
Molecular properties that influence the oral bioavailability of drug candidates
Veber, D. F., Johnson, S. R., Cheng, H.-Y., Smith, B. R., Ward, K. W., & Kopple, K. D. (2002) · Journal of Medicinal Chemistry · doi:10.1021/jm020017n · Cited by 8,420
The effect of particle design on cellular internalization pathways
Gratton, S. E. A., Ropp, P. A., Pohlhaus, P. D., Luft, J. C., Madden, V. J., Napier, M. E., & DeSimone, J. M. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0801763105 · Cited by 2,918
The influence of drug-like concepts on decision-making in medicinal chemistry
Leeson, P. D., & Springthorpe, B. (2007) · Nature Reviews Drug Discovery · doi:10.1038/nrd2445 · Cited by 2,403
Harush-Frenkel, O., Rozentur, E., Benita, S., & Altschuler, Y. (2008) · Biomacromolecules · doi:10.1021/bm700535p · Cited by 405
Chen, H., Kim, S., Li, L., Wang, S., Park, K., & Cheng, J.-X. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0707046105 · Cited by 394
Kalaria, D. R., Sharma, G., Beniwal, V., & Ravi Kumar, M. N. V. (2009) · Pharmaceutical Research · doi:10.1007/s11095-008-9763-4 · Cited by 246
Lipid-like Self-Assembling Peptides
Zhang, S. (2012) · Accounts of Chemical Research · doi:10.1021/ar300034v · Cited by 132
Cited by
Designing hydrogels for controlled drug delivery
Li, J., & Mooney, D. J. (2016) · Nature Reviews Materials · doi:10.1038/natrevmats.2016.71 · Cited by 4,832
Cheetham, A. G., Chakroun, R. W., Ma, W., & Cui, H. (2017) · Chem. Soc. Rev. · doi:10.1039/c7cs00521k · Cited by 367
Self-citationCheng, K., Ding, Y., Zhao, Y., Ye, S., Zhao, X., Zhang, Y., Ji, T., Wu, H., Wang, B., Anderson, G. J., et al. (2018) · Nano Letters · doi:10.1021/acs.nanolett.8b01071 · Cited by 325
Farkhani, S. M., Valizadeh, A., Karami, H., Mohammadi, S., Sohrabi, N., & Badrzadeh, F. (2014) · Peptides · doi:10.1016/j.peptides.2014.04.015 · Cited by 273
Drug-induced morphology switch in drug delivery systems based on poly(2-oxazoline)s
Schulz, A., Jaksch, S., Schubel, R., Wegener, E., Di, Z., Han, Y., Meister, A., Kressler, J., Kabanov, A. V., Luxenhofer, R., et al. (2014) · ACS Nano · doi:10.1021/nn406388t · Cited by 142
Metadata
- Authors
- Zhang, P., Cheetham, A. G., Lin, Y.-A., & Cui, H.
- Venue
- ACS Nano
- Publisher
- American Chemical Society (ACS)
- Published
- 2013-06-18
- Volume
- 7
- Issue
- 7
- Pages
- 5965-5977
- ISSN
- 1936-0851 (ISSN-L)
- 1936-086X
- OpenAlex
- W2329054428
- Cited by
- 209
- References
- 7
- FWCI
- 7.79
- Type
- journal article
- Language
- en
- Open access
- green
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