The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
Designing hydrogels for controlled drug delivery
Open accessAbstract
Hydrogel delivery systems can leverage therapeutically beneficial outcomes of drug delivery and have found clinical use. Hydrogels can provide spatial and temporal control over the release of various therapeutic agents, including small-molecule drugs, macromolecular drugs and cells. Owing to their tunable physical properties, controllable degradability and capability to protect labile drugs from degradation, hydrogels serve as a platform in which various physiochemical interactions with the encapsulated drugs control their release. In this Review, we cover multiscale mechanisms underlying the design of hydrogel drug delivery systems, focusing on physical and chemical properties of the hydrogel network and the hydrogel–drug interactions across the network, mesh, and molecular (or atomistic) scales. We discuss how different mechanisms interact and can be integrated to exert fine control in time and space over the drug presentation. We also collect experimental release data from the literature, review clinical translation to date of these systems, and present quantitative comparisons between different systems to provide guidelines for the rational design of hydrogel delivery systems.
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Metadata
- Authors
- Li, J., & Mooney, D. J.
- Venue
- Nature Reviews Materials
- Published
- 2016-10-18
- Volume
- 1
- Issue
- 12
- ISSN
- 2058-8437 (ISSN-L)
- OpenAlex
- W2539107597
- Cited by
- 4,832
- References
- 18
- FWCI
- 12.96
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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