The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Graphene Quantum Dots as Universal Fluorophores and Their Use in Revealing Regulated Trafficking of Insulin Receptors in Adipocytes
Open accessAbstract
Graphene quantum dots (GQDs) hold great promise as a new class of fluorophores for bioimaging, owing to their remarkable physicochemical properties including tunable photoluminescence, excellent photostability, and biocompatibility. Despite their highly anticipated potentials, GQDs have yet to be used to specifically label and track molecular targets involved in dynamic cellular processes in live cells. Here, we demonstrate that GQDs can serve as universal fluorophores for bioimaging because they can be readily conjugated with a wide range of biomolecules while preserving their functionalities. As a proof-of-concept demonstration, insulin-conjugated GQDs have been synthesized and utilized for specific labeling and dynamic tracking of insulin receptors in 3T3-L1 adipocytes. Our experiments reveal, for the first time, that the internalization and recycling of insulin receptors in adipocytes are oppositely regulated by apelin and TNFα, which may contribute to the regulations of these two cytokines in insulin sensitivity.
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Cites
Insulin signalling and the regulation of glucose and lipid metabolism
Saltiel, A. R., & Kahn, C. R. (2001) · Nature · doi:10.1038/414799a · Cited by 5,326
Probing cellular events, one quantum dot at a time
Pinaud, F., Clarke, S., Sittner, A., & Dahan, M. (2010) · Nature Methods · doi:10.1038/nmeth.1444 · Cited by 401
Cited by
Glowing Graphene Quantum Dots and Carbon Dots: Properties, Syntheses, and Biological Applications
Zheng, X. T., Ananthanarayanan, A., Luo, K. Q., & Chen, P. (2015) · Small · doi:10.1002/smll.201402648 · Cited by 2,190
Self-citationHeteroatom-doped graphene materials: syntheses, properties and applications
Wang, X., Sun, G., Routh, P., Kim, D.-H., Huang, W., & Chen, P. (2014) · Chem. Soc. Rev. · doi:10.1039/c4cs00141a · Cited by 1,891
Self-citationRevealing the tunable photoluminescence properties of graphene quantum dots
Sk, M. A., Ananthanarayanan, A., Huang, L., Lim, K. H., & Chen, P. (2014) · J. Mater. Chem. C · doi:10.1039/c4tc01191k · Cited by 698
Self-citationJu, J., & Chen, W. (2014) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2014.02.061 · Cited by 560
Iravani, S., & Varma, R. S. (2020) · Environmental Chemistry Letters · doi:10.1007/s10311-020-00984-0 · Cited by 532
Metadata
- Authors
- Zheng, X. T., Than, A., Ananthanaraya, A., Kim, D.-H., & Chen, P.
- Venue
- ACS Nano
- Publisher
- American Chemical Society (ACS)
- Published
- 2013-06-27
- Volume
- 7
- Issue
- 7
- Pages
- 6278-6286
- ISSN
- 1936-0851 (ISSN-L)
- 1936-086X
- OpenAlex
- W1993575187
- Cited by
- 245
- References
- 2
- FWCI
- 12.14
- Type
- journal article
- Language
- en
- Open access
- green
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