The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.
Toxicity Mechanisms in Escherichia coli Vary for Silver Nanoparticles and Differ from Ionic Silver
Abstract
Silver nanoparticles (Ag NPs) are commonly added to various consumer products and materials to impair bacterial growth. Recent studies suggested that the primary mechanism of antibacterial action of silver nanoparticles is release of silver ion (Ag(+)) and that particle-specific activity of silver nanoparticles is negligible. Here, we used a genome-wide library of Escherichia coli consisting of ∼4000 single gene deletion mutants to elucidate which physiological pathways are involved in how E. coli responds to different Ag NPs. The nanoparticles studied herein varied in both size and surface charge. AgNO3 was used as a control for soluble silver ions. Within a series of differently sized citrate-coated Ag NPs, smaller size resulted in higher Ag ion dissolution and toxicity. Nanoparticles functionalized with cationic, branched polyethylene imine (BPEI) exhibited equal toxicity with AgNO3. When we used a genome-wide approach to investigate the pathways involved in the response of E. coli to different toxicants, we found that only one of the particles (Ag-cit10) exhibited a pattern of response that was statistically similar to that of silver ion. By contrast, the pathways involved in E. coli response to Ag-BPEI particles were more similar to those observed for another cationic nanoparticle that did not contain Ag. Overall, we found that the pathways involved in bacterial responses to Ag nanoparticles are highly dependent on physicochemical properties of the nanoparticles, particularly the surface characteristics. These results have important implications for the regulation and testing of silver nanoparticles.
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Cited by
Silver nanoparticles: A new view on mechanistic aspects on antimicrobial activity
Durán, N., Durán, M., de Jesus, M. B., Seabra, A. B., Fávaro, W. J., & Nakazato, G. (2016) · Nanomedicine: Nanotechnology, Biology and Medicine · doi:10.1016/j.nano.2015.11.016 · Cited by 1,542
Antibacterial Activity of Silver Nanoparticles: Structural Effects
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Antibacterial properties and toxicity from metallic nanomaterials
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Valsami-Jones, E., & Lynch, I. (2015) · Science · doi:10.1126/science.aad0768 · Cited by 232
An evaluation of blood compatibility of silver nanoparticles
Huang, H., Lai, W., Cui, M., Liang, L., Lin, Y., Fang, Q., Liu, Y., & Xie, L. (2016) · Scientific Reports · doi:10.1038/srep25518 · Cited by 186
Metadata
- Authors
- Ivask, A., ElBadawy, A., Kaweeteerawat, C., Boren, D., Fischer, H., Ji, Z., Chang, C. H., Liu, R., Tolaymat, T., Telesca, D., Zink, J. I., Cohen, Y., Holden, P. A., & Godwin, H. A.
- Venue
- ACS Nano
- Publisher
- American Chemical Society (ACS)
- Published
- 2013-12-24
- Volume
- 8
- Issue
- 1
- Pages
- 374-386
- ISSN
- 1936-0851 (ISSN-L)
- 1936-086X
- OpenAlex
- W1969181076
- Cited by
- 599
- References
- 46
- FWCI
- 13.91
- Type
- journal article
- Language
- en
- Open access
- closed
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- Ivask, A., ElBadawy, A., Kaweeteerawat, C., Boren, D., Fischer, H., Ji, Z., Chang, C. H., Liu, R., Tolaymat, T., Telesca, D., Zink, J. I., Cohen, Y., Holden, P. A., & Godwin, H. A. (2014). Toxicity Mechanisms in Escherichia coli Vary for Silver Nanoparticles and Differ from Ionic Silver. ACS Nano. https://doi.org/10.1021/nn4044047
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