The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Compartmental Genomics in Living Cells Revealed by Single-Cell Nanobiopsy
Open accessAbstract
The ability to study the molecular biology of living single cells in heterogeneous cell populations is essential for next generation analysis of cellular circuitry and function. Here, we developed a single-cell nanobiopsy platform based on scanning ion conductance microscopy (SICM) for continuous sampling of intracellular content from individual cells. The nanobiopsy platform uses electrowetting within a nanopipette to extract cellular material from living cells with minimal disruption of the cellular milieu. We demonstrate the subcellular resolution of the nanobiopsy platform by isolating small subpopulations of mitochondria from single living cells, and quantify mutant mitochondrial genomes in those single cells with high throughput sequencing technology. These findings may provide the foundation for dynamic subcellular genomic analysis.
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Cites
Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin
Clark, I. E., Dodson, M. W., Jiang, C., Cao, J. H., Huh, J. R., Seol, J. H., Yoo, S. J., Hay, B. A., & Guo, M. (2006) · Nature · doi:10.1038/nature04779 · Cited by 1,788
Multifunctional carbon-nanotube cellular endoscopes.
Singhal, R., Orynbayeva, Z., Kalyana Sundaram, R. V., Niu, J. J., Bhattacharyya, S., Vitol, E. A., Schrlau, M. G., Papazoglou, E. S., Friedman, G., & Gogotsi, Y. (2011) · Nature Nanotechnology · doi:10.1038/nnano.2010.241 · Cited by 241
Quantitative PCR Analysis of DNA, RNAs, and Proteins in the Same Single Cell
Ståhlberg, A., Thomsen, C., Ruff, D., & Åman, P. (2012) · Clinical Chemistry · doi:10.1373/clinchem.2012.191445 · Cited by 78
Cited by
Perspective and Prospectus on Single-Entity Electrochemistry
Baker, L. A. (2018) · Journal of the American Chemical Society · doi:10.1021/jacs.8b09747 · Cited by 285
Metadata
- Authors
- Actis, P., Maalouf, M. M., Kim, H. J., Lohith, A., Vilozny, B., Seger, R. A., & Pourmand, N.
- Venue
- ACS Nano
- Publisher
- American Chemical Society (ACS)
- Published
- 2013-12-04
- Volume
- 8
- Issue
- 1
- Pages
- 546-553
- ISSN
- 1936-0851 (ISSN-L)
- 1936-086X
- OpenAlex
- W2036640181
- Cited by
- 183
- References
- 3
- FWCI
- 6.38
- Type
- journal article
- Language
- en
- Open access
- green
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