Cited by 241Nanopore and Nanochannel Transport StudiesGraphene and Nanomaterials ApplicationsForce Microscopy Techniques and Applications

Multifunctional carbon-nanotube cellular endoscopes.

Singhal, Riju, Orynbayeva, Zulfiya, Kalyana Sundaram, Ramalingam Venkat, Niu, Jun Jie, Bhattacharyya, Sayan, Vitol, Elina A., Schrlau, Michael G., Papazoglou, Elisabeth S. +2 more·2011·Nature Nanotechnology

Abstract

Glass micropipettes, atomic force microscope tips and nanoneedles can be used to interrogate cells, but these devices either have conical geometries that can damage cells during penetration or are incapable of continuous fluid handling. Here, we report a carbon-nanotube-based endoscope for interrogating cells, transporting fluids and performing optical and electrochemical diagnostics at the single organelle level. The endoscope, which is made by placing a multiwalled carbon nanotube (length, 50-60 µm) at the tip of a glass pipette, can probe the intracellular environment with a spatial resolution of ∼100 nm and can also access organelles without disrupting the cell. When the nanotube is filled with magnetic nanoparticles, the endoscope can be remotely manoeuvered to transport nanoparticles and attolitre volumes of fluids to and from precise locations. Because they are mounted on conventional glass micropipettes, the endoscopes readily fit standard instruments, creating a broad range of opportunities for minimally invasive intracellular probing, drug delivery and single-cell surgery.

Integrity signals

Registry

Crossref · 10.1038/nnano.2010.241

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  • Optical interrogation of individual cells and organelles with a spatial resolution of ∼100 nm might be enabled through the use of carbon-nanotube-based endoscopes that project from B/CI nanorobots.

    “Optical interrogation of individual cells and organelles with a spatial resolution of ∼100 nm might be enabled through the use of carbon-nanotube-based endoscopes that project from B/CI nanorobots (Singhal et al., 2011).”

    From Human Brain/Cloud Interface (2019) · cites this paper as Singhal et al., 2011

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Authors
Singhal, R., Orynbayeva, Z., Kalyana Sundaram, R. V., Niu, J. J., Bhattacharyya, S., Vitol, E. A., Schrlau, M. G., Papazoglou, E. S., Friedman, G., & Gogotsi, Y.
Affiliations
  • Drexel University (US)
  • Indian Institute of Science Education and Research Kolkata (IN)
Corresponding author
  • Friedman, Gary
  • Gogotsi, Yury
Venue
Nature Nanotechnology
Published
2010-12-12
Volume
6
Issue
1
Pages
57-64
ISSN
  • 1748-3387 (ISSN-L)
  • 1748-3395
OpenAlex
W1986684600
Cited by
241
References
33
Citations by year
2026: 2 · 2025: 10 · 2024: 8 · 2023: 9 · 2022: 10 · 2021: 17 · 2020: 11 · 2019: 9 · 2018: 20 · 2017: 18 · 2016: 24 · 2015: 16 · 2014: 23 · 2013: 27 · 2012: 23
FWCI
12.08
Type
journal article
Language
en
Open access
closed
Locations
  • Nature Nanotechnology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Science Foundation
  • W. M. Keck Foundation
  • Drexel University
Topics
  • Physical Sciences › Engineering › Biomedical Engineering › Nanopore and Nanochannel Transport Studies
  • Physical Sciences › Engineering › Biomedical Engineering › Graphene and Nanomaterials Applications
  • Physical Sciences › Physics and Astronomy › Atomic and Molecular Physics, and Optics › Force Microscopy Techniques and Applications
Keywords
multi-walled carbon nanotubes, glass micropipettes, magnetic nanoparticles, magnetic manipulation, fluid transport, drug delivery, optical diagnostics
MeSH terms
HeLa Cells, Humans, Microscopy, Electron, Scanning, Microscopy, Atomic Force, Nanotubes, Carbon, Electrochemical Techniques

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