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Laser-Activated Gene Silencing via Gold Nanoshell−siRNA Conjugates
Abstract
The temporal and spatial control over the delivery of materials such as siRNA into cells remains a significant technical challenge. We demonstrate the pulsed near-infrared (NIR) laser-dependent release of siRNA from coated 40 nm gold nanoshells. Tat-lipid coating mediates the cellular uptake of the nanomaterial at picomolar concentration, while spatiotemporal silencing of a reporter gene (green fluorescence protein) was studied using photomasking. The NIR laser-induced release of siRNA from the nanoshells is found to be power- and time-dependent, through surface-linker bond cleavage, while the escape of the siRNA from endosomes occurs above a critical pulse energy attributed to local heating and cavitation. NIR laser-controlled drug release from functional nanomaterials should facilitate more sophisticated developmental biology and therapeutic studies.
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Citations
Cites
Remote Optical Switch for Localized and Selective Control of Gene Interference
Lee, S. E., Liu, G. L., Kim, F., & Lee, L. P. (2009) · Nano Letters · doi:10.1021/nl802689k · Cited by 224
Cited by
Wang, F., Wang, Y.-C., Dou, S., Xiong, M.-H., Sun, T.-M., & Wang, J. (2011) · ACS Nano · doi:10.1021/nn200007z · Cited by 813
Guo, S., Huang, Y., Jiang, Q., Sun, Y., Deng, L., Liang, Z., Du, Q., Xing, J., Zhao, Y., Wang, P. C., et al. (2010) · ACS Nano · doi:10.1021/nn101638u · Cited by 401
Recent advances in metal nanoparticles in cancer therapy
Sharma, A., Goyal, A. K., & Rath, G. (2018) · Journal of Drug Targeting · doi:10.1080/1061186x.2017.1400553 · Cited by 341
Photoresponsive nanoparticles for drug delivery
Rwei, A. Y., Wang, W., & Kohane, D. S. (2015) · Nano Today · doi:10.1016/j.nantod.2015.06.004 · Cited by 318
Therapeutic platforms based on gold nanoparticles and their covalent conjugates with drug molecules
Vigderman, L., & Zubarev, E. R. (2013) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.05.004 · Cited by 305
Metadata
- Authors
- Braun, G. B., Pallaoro, A., Wu, G., Missirlis, D., Zasadzinski, J. A., Tirrell, M., & Reich, N. O.
- Venue
- ACS Nano
- Publisher
- American Chemical Society (ACS)
- Published
- 2009-06-15
- Volume
- 3
- Issue
- 7
- Pages
- 2007-2015
- ISSN
- 1936-0851 (ISSN-L)
- 1936-086X
- OpenAlex
- W2112166581
- Cited by
- 270
- References
- 1
- FWCI
- 9.48
- Type
- journal article
- Language
- en
- Open access
- closed
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- Braun, G. B., Pallaoro, A., Wu, G., Missirlis, D., Zasadzinski, J. A., Tirrell, M., & Reich, N. O. (2009). Laser-Activated Gene Silencing via Gold Nanoshell−siRNA Conjugates. ACS Nano. https://doi.org/10.1021/nn900469q
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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