Cited by 224RNA Interference and Gene DeliveryGold and Silver Nanoparticles Synthesis and ApplicationsAdvanced biosensing and bioanalysis techniques

Remote Optical Switch for Localized and Selective Control of Gene Interference

Open access
Lee, Somin Eunice, Liu, Gang Logan, Kim, Franklin, Lee, Luke P.·2009·Nano Letters

Abstract

Near infrared-absorbing gold nanoplasmonic particles (GNPs) are used as optical switches of gene interference and are remotely controlled using light. We have tuned optical switches to a wavelength where cellular photodamage is minimized. Optical switches are functionalized with double-stranded oligonucleotides. At desired times and at specific intracellular locations, remote optical excitation is used to liberate gene-interfering oligonucleotides. We demonstrate a novel gene-interfering technique offering spatial and temporal control, which is otherwise impossible using conventional gene-interfering techniques.

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Crossref · 10.1021/nl802689k

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  • NIR irradiation has been widely applied for targeted drug delivery in recent years.

    “This enables the wide application of NIR irradiation for targeted drug delivery, which has been explored in recent years [179,180].”

    From Recent Advances in Nanomicelles Delivery Systems. (2020) · cites this paper as [179]

    The paper’s Abstract describes NIR-triggered, localized release of gene-interfering oligonucleotides in cells, supporting a specific example of targeted release. It does not establish that NIR irradiation has been widely applied for targeted drug delivery in recent years. (LLM, conf=0.84)

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  1. [7]Hamad-Schifferli K Schwartz JJ Santos AT Zhang S Jacobsen JM Nature 2002 415 152 155 11805829

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Authors
Lee, S. E., Liu, G. L., Kim, F., & Lee, L. P.
Affiliations
University of Illinois Urbana-Champaign (US)
Corresponding author
Lee, Luke P.
Venue
Nano Letters
Published
2009-01-07
Volume
9
Issue
2
Pages
562-570
ISSN
  • 1530-6984 (ISSN-L)
  • 1530-6992
OpenAlex
W2076719191
Cited by
224
References
42
Citations by year
2025: 3 · 2024: 10 · 2023: 10 · 2022: 7 · 2021: 3 · 2020: 4 · 2019: 4 · 2018: 19 · 2017: 9 · 2016: 16 · 2015: 17 · 2014: 16 · 2013: 26 · 2012: 29
FWCI
10.73
Type
journal article
Language
en
Open access
Locations
  • Nano Letters (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Physical Science Consortium
  • National Institutes of Health
  • National Eye Institute (3PN2 EY01824, PN2EY018241)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
  • Physical Sciences › Materials Science › Electronic, Optical and Magnetic Materials › Gold and Silver Nanoparticles Synthesis and Applications
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Advanced biosensing and bioanalysis techniques
Keywords
optical switches, gold nanoparticles, nanoplasmonics, gene interference, oligonucleotides, near-infrared light, spatiotemporal control, intracellular delivery
MeSH terms
Cell Line, DNA, Gold, Erb-b2 Receptor Tyrosine Kinases, RNA Interference, Metal Nanoparticles

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