Remote Optical Switch for Localized and Selective Control of Gene Interference
Open accessAbstract
Near infrared-absorbing gold nanoplasmonic particles (GNPs) are used as optical switches of gene interference and are remotely controlled using light. We have tuned optical switches to a wavelength where cellular photodamage is minimized. Optical switches are functionalized with double-stranded oligonucleotides. At desired times and at specific intracellular locations, remote optical excitation is used to liberate gene-interfering oligonucleotides. We demonstrate a novel gene-interfering technique offering spatial and temporal control, which is otherwise impossible using conventional gene-interfering techniques.
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NIR irradiation has been widely applied for targeted drug delivery in recent years.
“This enables the wide application of NIR irradiation for targeted drug delivery, which has been explored in recent years [179,180].”
From Recent Advances in Nanomicelles Delivery Systems. (2020) · cites this paper as [179]
The paper’s Abstract describes NIR-triggered, localized release of gene-interfering oligonucleotides in cells, supporting a specific example of targeted release. It does not establish that NIR irradiation has been widely applied for targeted drug delivery in recent years. (LLM, conf=0.84)
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Cites
Cancer Cell Imaging and Photothermal Therapy in the Near-Infrared Region by Using Gold Nanorods
Huang, X., El‐Sayed, I. H., Qian, W. P., & El‐Sayed, M. A. (2006) · Journal of the American Chemical Society · doi:10.1021/ja057254a · Cited by 5,442 · see citing works
Preparation and Growth Mechanism of Gold Nanorods (NRs) Using Seed-Mediated Growth Method
Nikoobakht, B., & El‐Sayed, M. A. (2003) · Chemistry of Materials · doi:10.1021/cm020732l · Cited by 5,072 · see citing works
Construction of a genetic toggle switch in Escherichia coli
Gardner, T. S., Cantor, C. R., & Collins, J. J. (2000) · Nature · doi:10.1038/35002131 · Cited by 4,310 · see citing works
Nanoshell-mediated near-infrared thermal therapy of tumors under magnetic resonance guidance
Hirsch, L. R., Stafford, R. J., Bankson, J. A., Sershen, S. R., Rivera, B., Price, R. E., Hazle, J. D., Halas, N. J., & West, J. L. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2232479100 · Cited by 3,961 · see citing works
Link, S., & El‐Sayed, M. A. (2000) · International Reviews in Physical Chemistry · doi:10.1080/01442350050034180 · Cited by 2,392 · see citing works
Oligonucleotide-Modified Gold Nanoparticles for Intracellular Gene Regulation
Rosi, N. L., Giljohann, D. A., Thaxton, C. S., Lytton‐Jean, A. K. R., Han, M. S., & Mirkin, C. A. (2006) · Science · doi:10.1126/science.1125559 · Cited by 1,988 · see citing works
種結晶を媒介とした成長法を用いた金ナノロッド(NR)の調製と成長メカニズム
Nikoobakht, B., & El-Sayed, M. A. (2003) · Chemistry of Materials · Cited by 1,419 · see citing works
The Structure and Function of the Endothelial Glycocalyx Layer
Weinbaum, S., Tarbell, J. M., & Damiano, E. R. (2007) · Annual Review of Biomedical Engineering · doi:10.1146/annurev.bioeng.9.060906.151959 · Cited by 1,204 · see citing works
Nanotechnology Applications in Cancer
Nie, S., Xing, Y., Gloria, K., & Simons, J. W. (2007) · Annual Review of Biomedical Engineering · doi:10.1146/annurev.bioeng.9.060906.152025 · Cited by 1,125 · see citing works
Gene Regulation at the Single-Cell Level
Rosenfeld, N., Young, J. W., Alon, U., Swain, P. S., & Elowitz, M. B. (2005) · Science · doi:10.1126/science.1106914 · Cited by 1,104 · see citing works
Size-dependent DNA Mobility in Cytoplasm and Nucleus
Lukács, G. L., Haggie, P. M., Seksek, O., Lechardeur, D., Freedman, N. D., & Verkman, A. S. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.3.1625 · Cited by 752 · see citing works
RNA Silencing in Plants--Defense and Counterdefense
Vance, V. B., & Vaucheret, H. (2001) · Science · doi:10.1126/science.1061334 · Cited by 600 · see citing works
Highly efficient molecular delivery into mammalian cells using carbon nanotube spearing
Cai, D., Mataraza, J., Qin, Z., et al. (2005) · Nature Methods · doi:10.1038/nmeth761 · Cited by 552 · see citing works
The Role of Metal Nanoparticles in Remote Release of Encapsulated Materials
Skirtach, A. G., Déjugnat, C., Braun, D., et al. (2005) · Nano Letters · doi:10.1021/nl050693n · Cited by 532 · see citing works
Targeted Photothermal Lysis of the Pathogenic Bacteria, Pseudomonas aeruginosa, with Gold Nanorods
Norman, R. S., Stone, J. W., Gole, A. M., et al. (2007) · Nano Letters · doi:10.1021/nl0727056 · Cited by 505 · see citing works
Fine-Tuning the Shape of Gold Nanorods
Gou, L., & Murphy, C. J. (2005) · Chemistry of Materials · doi:10.1021/cm050525w · Cited by 498 · see citing works
Laser‐Induced Release of Encapsulated Materials inside Living Cells
Skirtach, A. G., Javier, A. M., Kreft, O., Köhler, K., Alberola, A. P., Möhwald, H., Parak, W. J., & Sukhorukov, G. B. (2006) · Angewandte Chemie International Edition · doi:10.1002/anie.200504599 · Cited by 497 · see citing works
Peterlinz, K. A., Georgiadis, R. M., Herne, T. M., & Tarlov, M. J. (1997) · Journal of the American Chemical Society · doi:10.1021/ja964326c · Cited by 478 · see citing works
Laser‐Induced Release of Encapsulated Materials inside Living Cells
Skirtach, A. G., Javier, A. M., Kreft, O., Köhler, K., Alberola, A. P., Möhwald, H., Parak, W. J., & Sukhorukov, G. B. (2006) · Angewandte Chemie · doi:10.1002/ange.200504599 · Cited by 455 · see citing works
Lu, Y., Liu, G. L., Kim, J. J., Mejia, Y. X., & Lee, L. P. (2004) · Nano Letters · doi:10.1021/nl048232+ · Cited by 439 · see citing works
Self-citationChen, C., Lin, Y.-P., Wang, C.-W., Tzeng, H.-C., Wu, C.-H., Chen, Y.-C., Chen, C.-P., Chen, L., & Wu, Y. (2006) · Journal of the American Chemical Society · doi:10.1021/ja0570180 · Cited by 425 · see citing works
Hamad‐Schifferli, K., Schwartz, J. J., Santos, A. T., Zhang, S., & Jacobson, J. M. (2002) · Nature · doi:10.1038/415152a · Cited by 398 · see citing works
Optical amplification of photothermal therapy with gold nanoparticles and nanoclusters
Khlebtsov, B. N., Zharov, V. P., Melnikov, A., Tuchin, V. V., & Khlebtsov, N. G. (2006) · Nanotechnology · doi:10.1088/0957-4484/17/20/022 · Cited by 375 · see citing works
Photo-mediated gene activation using caged RNA/DNA in zebrafish embryos
Ando, H., Furuta, T., Tsien, R. Y., et al. (2001) · Nature Genetics · doi:10.1038/ng583 · Cited by 368 · see citing works
Optofluidic control using photothermal nanoparticles
Liu, G. L., Kim, J. J., Lu, Y., & Lee, L. P. (2005) · Nature Materials · doi:10.1038/nmat1528 · Cited by 361 · see citing works
Self-citationGold nanoshell bioconjugates for molecular imaging in living cells
Loo, C. H., Hirsch, L. R., Lee, M., Chang, E., West, J. L., Halas, N. J., & Drezek, R. A. (2005) · Optics Letters · doi:10.1364/ol.30.001012 · Cited by 305 · see citing works
Light‐Activated RNA Interference
Shah, S., Rangarajan, S., & Friedman, S. H. (2005) · Angewandte Chemie International Edition · doi:10.1002/anie.200461458 · Cited by 206 · see citing works
Targeting Expression with Light Using Caged DNA*
Monroe, W., McQuain, M. M., Chang, M. S., Alexander, J., & Haselton, F. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.30.20895 · Cited by 157 · see citing works
Targeted destruction of murine macrophage cells with bioconjugated gold nanorods
Pissuwan, D., Valenzuela, S. M., Killingsworth, M. C., Xu, X., & Cortie, M. B. (2007) · Journal of Nanoparticle Research · doi:10.1007/s11051-007-9212-z · Cited by 130 · see citing works
Independent optically addressable nanoparticle-polymer optomechanical composites
Sershen, S. R., Westcott, S. L., Halas, N. J., et al. (2002) · Applied Physics Letters · doi:10.1063/1.1481536 · Cited by 128 · see citing works
A partnership between biology and engineering
Brent, R. (2004) · Nature Biotechnology · doi:10.1038/nbt1004-1211 · Cited by 111 · see citing works
Skirtach, A. G., Karageorgiev, P., Geest, B. G. D., et al. (2008) · Advanced Materials · doi:10.1002/adma.200701542 · Cited by 93 · see citing works
The inside scoop—evaluating gene delivery methods
Bonetta, L. P. (2005) · Nature Methods · doi:10.1038/nmeth1105-875 · Cited by 62 · see citing works
Site-specific incorporation of photoisomerizable azobenzene groups into ribonuclease S
Liu, D. M., Karanicolas, J., Yu, C., et al. (1997) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/s0960-894x(97)10044-0 · Cited by 56 · see citing works
Inhibition of the tissue reaction to a biodegradable biomaterial by monoclonal antibodies to IFN-?
Khouw, I. M. S. L., van Wachem, P. B., de Leij, L. F. M. H., & van Luyn, M. J. A. (1998) · Journal of Biomedical Materials Research · doi:10.1002/(sici)1097-4636(199808)41:2 · Cited by 53 · see citing works
Nanocarrier Stimuli‐Activated Gene Delivery
Howard, K. A., Dong, M., Oupický, D., et al. (2006) · Small · doi:10.1002/smll.200600328 · Cited by 48 · see citing works
Photo-responsive oligonucleotides carrying azobenzene at the 2′-position of uridine
Asanuma, H., Yoshida, T., Ito, T., et al. (1999) · Tetrahedron Letters · doi:10.1016/s0040-4039(99)01547-6 · Cited by 35 · see citing works
Expression of Plasmid DNA Released from DNA Conjugates of Gold Nanorods
Horiguchi, Y., Niidome, T., Yamada, S., Nakashima, N., & Niidome, Y. (2007) · Chemistry Letters · doi:10.1246/cl.2007.952 · Cited by 27 · see citing works
Guarneri, V., Bengala, C., Orlandini, C., et al. (2004) · Bone Marrow Transplantation · doi:10.1038/sj.bmt.1704619 · Cited by 12 · see citing works
Single cell resolution in regulation of gene expression
Bahcall, O. G. (2005) · Molecular Systems Biology · doi:10.1038/msb4100020 · Cited by 12 · see citing works
Brandt, B., Griwatz, C., Heidl, S., et al. (1996) · Clinical & Experimental Metastasis · doi:10.1007/bf00123399 · Cited by 7 · see citing works
Metafectene is Superior to Lipofectamine in the Transfection of Gsα Prostate Cancer Cells
Iczkowski, K. A., Omara-Opyene, A. L., & Klösel, R. (2004) · Molecular Biotechnology · doi:10.1385/mb:28:2:097 · Cited by 7 · see citing works
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- [7]Hamad-Schifferli K Schwartz JJ Santos AT Zhang S Jacobsen JM Nature 2002 415 152 155 11805829
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In vitro and ex vivo strategies for intracellular delivery
Stewart, M. P., Sharei, A., Ding, X., Sahay, G., Langer, R., & Jensen, K. F. (2016) · Nature · doi:10.1038/nature19764 · Cited by 885 · see citing works
Recent Advances in Nanomicelles Delivery Systems.
Tawfik, S. M., Azizov, S., Elmasry, M. R., Sharipov, M., & Lee, Y.-I. (2020) · Nanomaterials · doi:10.3390/nano11010070 · Cited by 156 · see citing works
“This enables the wide application of NIR irradiation for targeted drug delivery, which has been explored in recent years [179,180].”
BackgroundControlled-Release System of Small Molecules Triggered by the Photothermal Effect of Polypyrrole
Zhang, H., Xiong, L., Liao, X., & Huang, K. (2016) · Macromolecular Rapid Communications · doi:10.1002/marc.201500523 · Cited by 25 · see citing works
- Authors
- Lee, S. E., Liu, G. L., Kim, F., & Lee, L. P.
- Affiliations
- University of Illinois Urbana-Champaign (US)
- Corresponding author
- Lee, Luke P.
- Venue
- Nano Letters
- Publisher
- American Chemical Society (ACS)
- Published
- 2009-01-07
- Volume
- 9
- Issue
- 2
- Pages
- 562-570
- ISSN
- 1530-6984 (ISSN-L)
- 1530-6992
- PMC
- PMC2776650
- OpenAlex
- W2076719191
- Cited by
- 224
- References
- 42
- Citations by year
- 2025: 3 · 2024: 10 · 2023: 10 · 2022: 7 · 2021: 3 · 2020: 4 · 2019: 4 · 2018: 19 · 2017: 9 · 2016: 16 · 2015: 17 · 2014: 16 · 2013: 26 · 2012: 29
- FWCI
- 10.73
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nano Letters (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Physical Science Consortium
- National Institutes of Health
- National Eye Institute (3PN2 EY01824, PN2EY018241)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
- Physical Sciences › Materials Science › Electronic, Optical and Magnetic Materials › Gold and Silver Nanoparticles Synthesis and Applications
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Advanced biosensing and bioanalysis techniques
- Keywords
- optical switches, gold nanoparticles, nanoplasmonics, gene interference, oligonucleotides, near-infrared light, spatiotemporal control, intracellular delivery
- MeSH terms
- Cell Line, DNA, Gold, Erb-b2 Receptor Tyrosine Kinases, RNA Interference, Metal Nanoparticles
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