The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
A Drug-Loaded Aptamer−Gold Nanoparticle Bioconjugate for Combined CT Imaging and Therapy of Prostate Cancer
Abstract
Computed tomography (CT) is one of the most useful diagnostic tools among commonly used biomedical imaging techniques, which also include magnetic resonance imaging (MRI), positron emission tomography (PET), and ultrasound. However, currently available CT contrast agents, which are based on small iodinated molecules, possess a number of limitations, including a lack of targeted molecular imaging, short imaging time, and renal toxicity. Here, we report a multifunctional nanoparticle for targeted molecular CT imaging and therapy of prostate cancer. By functionalizing the surface of gold nanoparticles (GNPs) with a prostate-specific membrane antigen (PSMA) RNA aptamer that binds to PSMA, we established a targeted molecular CT imaging system capable of specific imaging of prostate cancer cells that express the PSMA protein. The resulting PSMA aptamer-conjugated GNP showed more than 4-fold greater CT intensity for a targeted LNCaP cell than that of a nontargeted PC3 cell. Furthermore, the PSMA aptamer-conjugated GNPs after loading of doxorubicin were significantly more potent against targeted LNCaP cells than against nontargeted PC3 cells.
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Cites
Multifunctional polymeric micelles as cancer-targeted, MRI-ultrasensitive drug delivery systems
Nasongkla, N., Bey, E., Ren, J., Ai, H., Khemtong, C., Guthi, J. S., Chin, S.-F., Sherry, A. D., Boothman, D. A., & Gao, J. (2006) · Nano Letters · doi:10.1021/nl061412u · Cited by 1,238
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Gold Nanomaterials at Work in Biomedicine
Yang, X., Yang, M., Pang, B., Vara, M., & Xia, Y. (2015) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00193 · Cited by 1,162
Recent Progress in Cancer Thermal Therapy Using Gold Nanoparticles
Abadeer, N. S., & Murphy, C. J. (2016) · The Journal of Physical Chemistry C · doi:10.1021/acs.jpcc.5b11232 · Cited by 919
Lee, N., Choi, S. H., & Hyeon, T. (2013) · Advanced Materials · doi:10.1002/adma.201300081 · Cited by 657
Unique Roles of Gold Nanoparticles in Drug Delivery, Targeting and Imaging Applications
Kong, F.-Y., Zhang, J.-W., Li, R.-F., Wang, Z.-X., Wang, W.-J., & Wang, W. (2017) · Molecules · doi:10.3390/molecules22091445 · Cited by 615
Various methods of gold nanoparticles (GNPs) conjugation to antibodies
Jazayeri, M. H., Amani, H., Pourfatollah, A. A., Pazoki-Toroudi, H., & Sedighimoghaddam, B. (2016) · Sensing and Bio-Sensing Research · doi:10.1016/j.sbsr.2016.04.002 · Cited by 528
Metadata
- Authors
- Kim, D., Jeong, Y. Y., & Jon, S.
- Venue
- ACS Nano
- Publisher
- American Chemical Society (ACS)
- Published
- 2010-06-15
- Volume
- 4
- Issue
- 7
- Pages
- 3689-3696
- ISSN
- 1936-0851 (ISSN-L)
- 1936-086X
- OpenAlex
- W1965428790
- Cited by
- 726
- References
- 1
- FWCI
- 28.40
- Type
- journal article
- Language
- en
- Open access
- closed
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