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Trichodermamides A and B, Cytotoxic Modified Dipeptides from the Marine-Derived Fungus Trichoderma virens
Abstract
Trichodermamides A (1) and B (2), two modified dipeptides, have been isolated from cultures of the marine-derived fungus Trichoderma virens. The trichodermamides possess a rare cyclic O-alkyl-oxime functionality incorporated into a six-membered ring. The structure of trichodermamide B was established by X-ray diffraction analysis, while the structure assignment of trichodermamide A, and determination of the absolute stereochemistry, was accomplished by spectral and chemical methods. Trichodermamide B displayed significant in vitro cytotoxicity against HCT-116 human colon carcinoma with an IC(50) of 0.32 microg/mL.
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Citations
Cited by
Faulkner, D. J. (1990) · Natural Product Reports · doi:10.1039/np9900700269 · Cited by 4,866
Trichoderma: The “Secrets” of a Multitalented Biocontrol Agent
Sood, M., Kapoor, D., Kumar, V., Sheteiwy, M. S., Ramakrishnan, M., Landi, M., Araniti, F., & Sharma, A. (2020) · Plants · doi:10.3390/plants9060762 · Cited by 650
Marine natural products of fungal origin
Saleem, M., Ali, M. S., Hussain, S., Jabbar, A., Ashraf, M., & Lee, Y. S. (2007) · Natural Product Reports · doi:10.1039/b607254m · Cited by 326
Bhadury, P., Mohammad, B. T., & Wright, P. C. (2006) · Journal of Industrial Microbiology & Biotechnology · doi:10.1007/s10295-005-0070-3 · Cited by 250
Metadata
- Authors
- Garo, E., Starks, C. M., Jensen, P. R., Fenical, W., Lobkovsky, E., & Clardy, J.
- Venue
- Journal of Natural Products
- Publisher
- American Chemical Society (ACS)
- Published
- 2003-02-12
- Volume
- 66
- Issue
- 3
- Pages
- 423-426
- ISSN
- 0163-3864 (ISSN-L)
- 1520-6025
- OpenAlex
- W1977345467
- Cited by
- 189
- References
- 0
- FWCI
- 3.39
- Type
- journal article
- Language
- en
- Open access
- closed
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- Garo, E., Starks, C. M., Jensen, P. R., Fenical, W., Lobkovsky, E., & Clardy, J. (2003). Trichodermamides A and B, Cytotoxic Modified Dipeptides from the Marine-Derived Fungus Trichoderma virens. Journal of Natural Products. https://doi.org/10.1021/np0204390
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