The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
Camptothecin and Taxol: Historic Achievements in Natural Products Research
Abstract
The research team of Dr. Monroe E. Wall and Dr. Mansukh C. Wani of Research Triangle Institute discovered two first-in-class life-saving chemotherapeutic agents. Camptothecin, first isolated and identified from Camptotheca acuminata, was found to kill cancer cells uniquely via topoisomerase I poisoning. Presently, two first-generation analogues of camptothecin are used to treat ovarian, colorectal, and small-cell lung cancers, and several second-generation analogues are in clinical trials. Taxol, first isolated and identified by Wall and Wani from Taxus brevifolia, was found to inhibit cancer cell growth via the stabilization of microtubules. In 1992, taxol was approved for refractory ovarian cancer and today is used against breast and non-small cell lung cancers and in Kaposi's sarcoma. While there have been numerous reviews of these molecules individually, this review offers an integrated account of the research team of "Wall and Wani" and the significance of their discoveries to chemistry, biology, and clinical medicine.
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Cites
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Cited by
Charting, Navigating, and Populating Natural Product Chemical Space for Drug Discovery
Lachance, H., Wetzel, S., Kumar, K., & Waldmann, H. (2012) · Journal of Medicinal Chemistry · doi:10.1021/jm300288g · Cited by 398
Kellogg, J. J., Todd, D. A., Egan, J. M., Raja, H. A., Oberlies, N. H., Kvalheim, O. M., & Cech, N. B. (2016) · Journal of Natural Products · doi:10.1021/acs.jnatprod.5b01014 · Cited by 189
Self-citationFeng, G., Zhang, X.-S., Zhang, Z.-K., Ye, H.-C., Liu, Y.-Q., Yang, G.-Z., Chen, C., Chen, M., Yan, C., Wang, L.-Y., et al. (2019) · Postharvest Biology and Technology · doi:10.1016/j.postharvbio.2018.09.019 · Cited by 52
Metadata
- Authors
- Oberlies, N. H., & Kroll, D. J.
- Venue
- Journal of Natural Products
- Publisher
- American Chemical Society (ACS)
- Published
- 2004-01-16
- Volume
- 67
- Issue
- 2
- Pages
- 129-135
- ISSN
- 0163-3864 (ISSN-L)
- 1520-6025
- OpenAlex
- W2096956453
- Cited by
- 353
- References
- 17
- FWCI
- 3.61
- Type
- journal article
- Language
- en
- Open access
- closed
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