The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Adriamycin-Induced DNA Damage Mediated by Mammalian DNA Topoisomerase II
Abstract
Adriamycin (doxorubicin), a potent antitumor drug in clinical use, interacts with nucleic acids and cell membranes, but the molecular basis for its antitumor activity is unknown. Similar to a number of intercalative antitumor drugs and nonintercalative epipodophyllotoxins (VP-16 and VM-26), adriamycin has been shown to induce single- and double-strand breaks in DNA. These strand breaks are unusual because a covalently bound protein appears to be associated with each broken phosphodiester bond. In studies in vitro, mammalian DNA topoisomerase II mediates DNA damage by adriamycin and other related antitumor drugs.
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Cites
Fridovich (1978) · doi:10.1126/science.210504 · Cited by 3,329
Gellert, M. (1981) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.50.070181.004311 · Cited by 989
Tewey, K. M., Chen, G. L., Nelson, E. M., & Liu, L. F. (1984) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)47282-6 · Cited by 887
Self-citationThe Anticancer Agent Adriamycin Can Be Actively Cytotoxic Without Entering Cells
Triton, T. R., & Yee, G. (1982) · Science · doi:10.1126/science.7089561 · Cited by 571
Nelson, E. M., Tewey, K. M., & Liu, L. F. (1984) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.81.5.1361 · Cited by 558
Self-citationLIU, L., LIU, C., & ALBERTS, B. (1980) · Cell · doi:10.1016/s0092-8674(80)80046-8 · Cited by 550
Self-citationCleavage of DNA by mammalian DNA topoisomerase II.
Liu, L. F., Rowe, T. C., Yang, L., Tewey, K. M., & Chen, G. L. (1983) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)43815-4 · Cited by 533
Self-citationChen, G. L., Yang, L., Rowe, T. C., Halligan, B. D., Tewey, K. M., & Liu, L. F. (1984) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)90729-5 · Cited by 492
Self-citationA homogeneous type II DNA topoisomerase from HeLa cell nuclei.
Miller, K. G., Liu, L. F., & Englund, P. T. (1981) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)52552-2 · Cited by 356
Self-citationDouble strand DNA cleavage by type II DNA topoisomerase from Drosophila melanogaster.
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Cited by
Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I.
Hsiang, Y. H., Hertzberg, R., Hecht, S., & Liu, L. F. (1985) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)38654-4 · Cited by 2,362
Self-citationDoxorubicin pathways: pharmacodynamics and adverse effects
Thorn, C. F., Oshiro, C., Marsh, S., Hernandez-Boussard, T., McLeod, H., Klein, T. E., & Altman, R. B. (2011) · Pharmacogenetics and Genomics · doi:10.1097/fpc.0b013e32833ffb56 · Cited by 1,648
Inhibition of Mitochondrial Translation as a Therapeutic Strategy for Human Acute Myeloid Leukemia
Škrtić, M., Sriskanthadevan, S., Jhas, B., Gebbia, M., Wang, X., Wang, Z., Hurren, R., Jitkova, Y., Gronda, M., Maclean, N., et al. (2011) · Cancer Cell · doi:10.1016/j.ccr.2011.10.015 · Cited by 678
Andrew MacKay, J., Chen, M., McDaniel, J. R., Liu, W., Simnick, A. J., & Chilkoti, A. (2009) · Nature Materials · doi:10.1038/nmat2569 · Cited by 580
Fischer, M., Grossmann, P., Padi, M., & DeCaprio, J. A. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkw523 · Cited by 330
Metadata
- Authors
- Tewey, K. M., Rowe, T. C., Yang, L., Halligan, B. D., & Liu, L. F.
- Venue
- Science
- Published
- 1984-10-26
- Volume
- 226
- Issue
- 4673
- Pages
- 466-468
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2016254453
- Cited by
- 1,538
- References
- 14
- FWCI
- 10.62
- Type
- journal article
- Language
- en
- Open access
- closed
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- Tewey, K. M., Rowe, T. C., Yang, L., Halligan, B. D., & Liu, L. F. (1984). Adriamycin-Induced DNA Damage Mediated by Mammalian DNA Topoisomerase II. Science. https://doi.org/10.1126/science.6093249
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
