The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Isolation of an Antiviral Polysaccharide, Nostoflan, from a Terrestrial Cyanobacterium, Nostoc flagelliforme
Abstract
A novel acidic polysaccharide, nostoflan, was isolated from a terrestrial cyanobacterium, Nostoc flagelliforme. Nostoflan exhibited a potent anti-herpes simplex virus type 1 (HSV-1) activity with a selectivity index (50% cytotoxic concentration/50% inhibitory concentration against viral replication) of 13,000. Sugar composition and methylation analyses revealed that it was mainly composed of -->4)-D-Glcp-(1-->, -->6,4)-D-Glcp-(1-->, -->4)-D-Galp-(1-->, -->4)-D-Xylp-(1-->, D-GlcAp-(1-->, D-Manp-(1--> with a ratio of ca. 1:1:1:1:0.8:0.2. Two pyridylaminated oligosaccharides were prepared by partial acid hydrolysis and pyridylamination. On the basis of MALDI-TOF-MS and NMR analyses, they were found to be beta-D-Glcp-(1-->4)-D-Xyl-PA and beta-D-GlcAp-(1-->6)-beta-D-Glcp-(1-->4)-D-Gal-PA. From these results, nostoflan might be mainly composed of the following two types of sugar sequence: -->4)-beta-D-Glcp-(1-->4)-D-Xylp-(1--> and -->4)-[beta-D-GlcAp-(1-->6)-]-beta-D-Glcp-(1-->4)-D-Galp-(1-->. Besides anti-HSV-1 activity, nostoflan showed potent antiviral activities against HSV-2, human cytomegalovirus, and influenza A virus, but no activity against adenovirus and coxsackie virus was observed. Therefore, nostoflan has a broad antiviral spectrum against enveloped viruses whose cellular receptors are carbohydrates. Furthermore, nostoflan showed no antithrombin activity, unlike sulfated polysaccharides.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
New method for quantitative determination of uronic acids
Blumenkrantz, N., & Asboe-Hansen, G. (1973) · Analytical Biochemistry · doi:10.1016/0003-2697(73)90377-1 · Cited by 7,140
Hayashi, T., Hayashi, K., Maeda, M., & Kojima, I. (1996) · Journal of Natural Products · doi:10.1021/np960017o · Cited by 422
Self-citation
Cited by
Bioactivities, isolation and purification methods of polysaccharides from natural products: A review
Shi, L. (2016) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2016.06.100 · Cited by 559
Innovative natural functional ingredients from microalgae
Plaza, M., Herrero, M., Cifuentes, A., & Ibáñez, E. (2009) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf901070g · Cited by 509
Cyanobacteria: an emerging source for drug discovery
Singh, R. K., Tiwari, S. P., Rai, A. K., & Mohapatra, T. M. (2011) · The Journal of Antibiotics · doi:10.1038/ja.2011.21 · Cited by 370
Andrade, L. M. (2018) · MOJ Food Processing & Technology · doi:10.15406/mojfpt.2018.06.00144 · Cited by 272
Yu, H., Jia, S., & Dai, Y. (2009) · Journal of Applied Phycology · doi:10.1007/s10811-008-9341-5 · Cited by 158
Bioactive compounds from microalgae: Current development and prospects
Fu, W., Nelson, D. R., Yi, Z., Xu, M., Khraiwesh, B., Jijakli, K., Chaiboonchoe, A., Alzahmi, A., Al-Khairy, D., Brynjolfsson, S., et al. (2017) · Studies in natural products chemistry · doi:10.1016/b978-0-444-63929-5.00006-1 · Cited by 121
Antiviral Cyanometabolites—A Review
Mazur-Marzec, H., Cegłowska, M., Konkel, R., & Pyrć, K. (2021) · Biomolecules · doi:10.3390/biom11030474 · Cited by 64
Cyanotherapeutics: An emerging field for future drug discovery
Tiwari, A. K., & Tiwari, B. S. (2020) · Applied Phycology · doi:10.1080/26388081.2020.1744480 · Cited by 49
Dhandayuthapani, K., Malathy, S., Mulla, S. I., & Gupta, S. K. (2021) · Algae · doi:10.1007/978-981-15-7518-1_7 · Cited by 19
Metadata
- Authors
- Kanekiyo, K., Lee, J.-B., Hayashi, K., Takenaka, H., Hayakawa, Y., Endo, S., & Hayashi, T.
- Venue
- Journal of Natural Products
- Publisher
- American Chemical Society (ACS)
- Published
- 2005-06-11
- Volume
- 68
- Issue
- 7
- Pages
- 1037-1041
- ISSN
- 0163-3864 (ISSN-L)
- 1520-6025
- OpenAlex
- W2033526052
- Cited by
- 195
- References
- 2
- FWCI
- 8.57
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
