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Cited by 1,032Microbial Natural Products and BiosynthesisPlant-Microbe Interactions and ImmunityPlant and fungal interactions

Natural Products from Plant-Associated Microorganisms: Distribution, Structural Diversity, Bioactivity, and Implications of Their Occurrence

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Gunatilaka, A. A. Leslie·2006·Journal of Natural Products
DOI 10.1021/np058128nPMC PMC3362121
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Abstract

A growing body of evidence suggests that plant-associated microorganisms, especially endophytic and rhizosphere bacteria and fungi, represent a huge and largely untapped resource of natural products with chemical structures that have been optimized by evolution for biological and ecological relevance. A diverse array of bioactive small molecule natural products has been encountered in these microorganisms. The structures of over 230 metabolites isolated and characterized from over 70 plant-associated microbial strains during the past four years are presented with information on their hosts, culture conditions, and biological activities. Some significant biological and ecological implications of their occurrence are also reviewed.

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Authors
Gunatilaka, A. A. L.
Affiliations
University of Arizona (US)
Corresponding author
Gunatilaka, A. A. Leslie
ORCID
Gunatilaka, A. A. Leslie
Venue
Journal of Natural Products
Publisher
American Chemical Society (ACS)
Published
2006-03-01
Volume
69
Issue
3
Pages
509-526
ISSN
  • 0163-3864 (ISSN-L)
  • 1520-6025
DOI
10.1021/np058128n
PMC
PMC3362121
OpenAlex
W2120763351
Cited by
1,032
References
121
Citations by year
2026: 13 · 2025: 32 · 2024: 54 · 2023: 42 · 2022: 69 · 2021: 67 · 2020: 79 · 2019: 85 · 2018: 62 · 2017: 58 · 2016: 49 · 2015: 74 · 2014: 66 · 2013: 58 · 2012: 61
FWCI
2.66
Type
journal article
Language
en
Open access
Locations
  • Journal of Natural Products (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Cancer Institute (R01 CA90265, R01CA090265)
Topics
  • Health Sciences › Medicine › Pharmacology › Microbial Natural Products and Biosynthesis
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant-Microbe Interactions and Immunity
  • Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Plant and fungal interactions
Keywords
plant-associated microorganisms, endophytic bacteria, endophytic fungi, rhizosphere bacteria, rhizosphere fungi, natural products, microbial metabolites, structural diversity, biological activity, host-microbe interactions
MeSH terms
Bacteria, Biological Products, Fungi, Plants, Symbiosis, Molecular Structure

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