Evaluation of Anti-Inflammatory Activity of Prenylated Substances Isolated from Morus alba and Morus nigra
Abstract
Chromatographic separation of root extracts of Morus alba and M. nigra led to the identification of the 2-arylbenzofurans moracin C (1), mulberrofuran Y (2), and mulberrofuran H (3), and the prenylated flavonoids kuwanon E (4), kuwanon C (5), sanggenon H (6), cudraflavone B (7), and morusinol (8), and the Diels-Alder adducts soroceal (9), and sanggenon E (10). The cytotoxicity and their antiphlogistic activity, determined as the attenuation of the secretion of TNF-α and IL-1β and the inhibition of NF-κB nuclear translocation in LPS-stimulated macrophages, were evaluated for compounds 1-10.
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Morusinol reportedly regulates beta3-integrin, tumor necrosis factor, and interleukin 1 beta involved in osteoclastogenesis.
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From Targeting Msx2 as a brake in the fusion fate of osteoclasts and an anabolic therapy in pre-clinical models of osteoporosis (2025) · cites this paper as [36]
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- Authors
- Zelová, H., Hanáková, Z., Čermáková, Z., Šmejkal, K., Dalĺ Acqua, S., Babula, P., Cvačka, J., & Hošek, J.
- Affiliations
- University of Veterinary Sciences Brno (CZ)
- Department of Drug Sciences, University of Padua, I-351 31 Padua, Italy
- Czech Academy of Sciences (CZ)
- Corresponding author
- Hošek, Jan
- Venue
- Journal of Natural Products
- Publisher
- American Chemical Society (ACS)
- Published
- 2014-06-05
- Volume
- 77
- Issue
- 6
- Pages
- 1297-1303
- ISSN
- 0163-3864 (ISSN-L)
- 1520-6025
- OpenAlex
- W2331795948
- Cited by
- 99
- References
- 51
- Citations by year
- 2026: 3 · 2025: 13 · 2024: 7 · 2023: 8 · 2022: 9 · 2021: 12 · 2020: 6 · 2019: 6 · 2018: 13 · 2017: 5 · 2016: 9 · 2015: 7 · 2014: 1
- FWCI
- 3.14
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Natural Products (publishedVersion)
- PubMed (publishedVersion)
- ASEP (submittedVersion, public-domain)
- Padua Research Archive (University of Padova) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bioactive natural compounds
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Phytochemistry and Biological Activities
- Health Sciences › Medicine › Pharmacology › Synthesis of Organic Compounds
- Keywords
- Morus alba, Morus nigra, prenylated flavonoids, 2-arylbenzofurans, anti-inflammatory activity, cytotoxicity, TNF-α, IL-1β, NF-κB nuclear translocation, LPS-stimulated macrophages, root extract, Diels-Alder adducts
- MeSH terms
- Animals, Anti-Inflammatory Agents, Benzofurans, Benzopyrans, Flavonoids, Humans, Lipopolysaccharides, Macrophages, Tumor Necrosis Factor-alpha, Molecular Structure, NF-kappa B, Plant Roots, Plant Bark, Morus, Mice, Prenylation
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