Cited by 99Bioactive natural compoundsPhytochemistry and Biological ActivitiesSynthesis of Organic Compounds

Evaluation of Anti-Inflammatory Activity of Prenylated Substances Isolated from Morus alba and Morus nigra

Zelová, Hana, Hanáková, Zuzana, Čermáková, Zuzana, Šmejkal, Karel, Dalĺ Acqua, Stefano, Babula, Petr, Cvačka, Josef, Hošek, Jan·2014·Journal of Natural Products

Abstract

Chromatographic separation of root extracts of Morus alba and M. nigra led to the identification of the 2-arylbenzofurans moracin C (1), mulberrofuran Y (2), and mulberrofuran H (3), and the prenylated flavonoids kuwanon E (4), kuwanon C (5), sanggenon H (6), cudraflavone B (7), and morusinol (8), and the Diels-Alder adducts soroceal (9), and sanggenon E (10). The cytotoxicity and their antiphlogistic activity, determined as the attenuation of the secretion of TNF-α and IL-1β and the inhibition of NF-κB nuclear translocation in LPS-stimulated macrophages, were evaluated for compounds 1-10.

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Crossref · 10.1021/np401025f

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Authors
Zelová, H., Hanáková, Z., Čermáková, Z., Šmejkal, K., Dalĺ Acqua, S., Babula, P., Cvačka, J., & Hošek, J.
Affiliations
  • University of Veterinary Sciences Brno (CZ)
  • Department of Drug Sciences, University of Padua, I-351 31 Padua, Italy
  • Czech Academy of Sciences (CZ)
Corresponding author
Hošek, Jan
Venue
Journal of Natural Products
Published
2014-06-05
Volume
77
Issue
6
Pages
1297-1303
ISSN
  • 0163-3864 (ISSN-L)
  • 1520-6025
OpenAlex
W2331795948
Cited by
99
References
51
Citations by year
2026: 3 · 2025: 13 · 2024: 7 · 2023: 8 · 2022: 9 · 2021: 12 · 2020: 6 · 2019: 6 · 2018: 13 · 2017: 5 · 2016: 9 · 2015: 7 · 2014: 1
FWCI
3.14
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Natural Products (publishedVersion)
  • PubMed (publishedVersion)
  • ASEP (submittedVersion, public-domain)
  • Padua Research Archive (University of Padova) (submittedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bioactive natural compounds
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Phytochemistry and Biological Activities
  • Health Sciences › Medicine › Pharmacology › Synthesis of Organic Compounds
Keywords
Morus alba, Morus nigra, prenylated flavonoids, 2-arylbenzofurans, anti-inflammatory activity, cytotoxicity, TNF-α, IL-1β, NF-κB nuclear translocation, LPS-stimulated macrophages, root extract, Diels-Alder adducts
MeSH terms
Animals, Anti-Inflammatory Agents, Benzofurans, Benzopyrans, Flavonoids, Humans, Lipopolysaccharides, Macrophages, Tumor Necrosis Factor-alpha, Molecular Structure, NF-kappa B, Plant Roots, Plant Bark, Morus, Mice, Prenylation

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