Isolation and Hypoglycemic Activity of Eleutherans A, B, C, D, E, F, and G: Glycans of Eleutherococcus senticosus Roots

Hikino, Hiroshi; Takahashi, Michiko; Otake, Kazuko; Konno, Chohachi

doi:10.1021/np50044a015

Cited by 56Natural Antidiabetic Agents StudiesMedicinal Plants and Bioactive CompoundsMedicinal Plant Research

Isolation and Hypoglycemic Activity of Eleutherans A, B, C, D, E, F, and G: Glycans of Eleutherococcus senticosus Roots

Hikino, Hiroshi, Takahashi, Michiko, Otake, Kazuko, Konno, Chohachi·1986·Journal of Natural Products

DOI 10.1021/np50044a015

Open this paper in CoChat — free account

Abstract

Intraperitoneal injection of an aqueous extract of the crude drug "shigoka" (Siberian ginseng), Eleutherococcus senticosus roots, remarkably diminished plasma-sugar level in mice. Fractionation of the extract by monitoring the activity yielded seven glycans, eleutherans A, B, C, D, E, F, and G, which exerted marked hypoglycemic effects in normal and alloxan-induced hyperglycemic mice.

Integrity signals

Registry

Crossref · 10.1021/np50044a015

Cites

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Extracts of Eleutherococcus senticosus root stimulate the immune system, influence adaptation against external factors, improve mental and physical conditions and memory functions, and have a hypoglycaemic and anti-inflammatory effect.
“Extracts of Eleutherococcus senticosus root are obtained, stimulating the immune system, influencing adaptation against external factors, improving mental and physical conditions and memory functions, and have a hypoglycaemic effect and are anti-inflammatory [13,45,46].”
From Plant Adaptogens—History and Future Perspectives (2021) · cites this paper as [13]

Sorted by citations

A review of natural products and plants as potential antidiabetic drugs
Ivorra, M. D., Payá, M., & Villar, A. (1989) · Journal of Ethnopharmacology · doi:10.1016/0378-8741(89)90001-9 · Cited by 432 · see citing works
Eleutherococcus senticosus (Rupr. & Maxim.) Maxim. (Araliaceae) as an adaptogen: a closer look
Davydov, M., & Krikorian, A. D. (2000) · Journal of Ethnopharmacology · doi:10.1016/s0378-8741(00)00181-1 · Cited by 256 · see citing works
“Later, additional chemical work on the isolation of various constituents and studies on their chemistry were done by German (cf. e.g. Wagner et al., 1982; von Wagner et al., 1984), Chinese (cf. e.g. Fang et al., 1985) and Japanese scientists (cf. e.g. Hikino et al., 1986).”
Background
Natural Products Used for Diabetes
Shapiro, K., & Gong, W. C. (2002) · Journal of the American Pharmaceutical Association (1996) · doi:10.1331/108658002763508515 · Cited by 195 · see citing works
Bioactive polysaccharides from plants
Srivastava, R., & Kulshreshtha, D. K. (1989) · Phytochemistry · doi:10.1016/0031-9422(89)80245-6 · Cited by 176 · see citing works
Evaluation of the Ergogenic Properties of Ginseng
Bahrke, M. S., & Morgan, W. P. (1994) · Sports Medicine · doi:10.2165/00007256-199418040-00003 · Cited by 143 · see citing works
Antidiabetic effect of compounds isolated from plants
G., R. M. P., Zavala-Sánchez, M. Á., G., S. P., et al. (1998) · Phytomedicine · doi:10.1016/s0944-7113(98)80060-3 · Cited by 123 · see citing works
Plant Adaptogens—History and Future Perspectives
Todorova, V., Ivanov, K., Delattre, C., Nalbantova, V., Karcheva-Bahchevanska, D., & Ivanova, S. (2021) · Nutrients · doi:10.3390/nu13082861 · Cited by 121 · see citing works
Nature's own pharmacy: The diabetes perspective
Gray, A. M., & Flatt, P. R. (1997) · Proceedings of The Nutrition Society · doi:10.1079/pns19970051 · Cited by 101 · see citing works
Decreasing, Null and Increasing Effects of Eight Popular Types of Ginseng on Acute Postprandial Glycemic Indices in Healthy Humans: The Role of Ginsenosides
Sievenpiper, J. L., Arnason, J. T., Leiter, L. A., & Vuksan, V. V. V. (2004) · Journal of the American College of Nutrition · doi:10.1080/07315724.2004.10719368 · Cited by 99 · see citing works
The Ecology and Biology of Panax quinquefolium L. (Araliaceae) in Illinois
Anderson, R. C., Fralish, J. S., Armstrong, J. E., et al. (1993) · The American Midland Naturalist · doi:10.2307/2426517 · Cited by 83 · see citing works
Comparison between the Biological Active Compounds in Plants with Adaptogenic Properties (Rhaponticum carthamoides, Lepidium meyenii, Eleutherococcus senticosus and Panax ginseng)
Todorova, V., Ivanov, K., & Ivanova, S. (2021) · Plants · doi:10.3390/plants11010064 · Cited by 56 · see citing works
Pharmacognosy: phytomedicines and their mechanisms
Larkins, N., & Wynn, S. G. (2004) · Veterinary Clinics of North America Small Animal Practice · doi:10.1016/j.cvsm.2003.09.006 · Cited by 52 · see citing works
Release of acetylcholine by syringin, an active principle of Eleutherococcus senticosus, to raise insulin secretion in Wistar rats
Liu, K. Y., Wu, Y., Liu, I.-M., Yu, W. C., & Cheng, J. (2008) · Neuroscience Letters · doi:10.1016/j.neulet.2008.01.054 · Cited by 51 · see citing works
Phytochemicals as potential hypoglycemic agents
Lambaxc, S. S., Buch, K. Y., Lewis, H., et al. (2000) · Studies in natural products chemistry · doi:10.1016/s1572-5995(00)80012-5 · Cited by 50 · see citing works
Herbal Medicines in Pregnancy and Lactation: An Evidence-Based Approach
Mills, E. J., Duguoa, J.-J., Perri, D., & Koren, G. (2006) · Cited by 50 · see citing works
Effect of Asian and Siberian Ginseng on Serum Digoxin Measurement by Five Digoxin Immunoassays
Dasgupta, A., Wu, S., Actor, J. K., et al. (2003) · American Journal of Clinical Pathology · doi:10.1309/34bjecp7uk6fh13v · Cited by 44 · see citing works
Study of interaction between syringin and human serum albumin by multi-spectroscopic method and atomic force microscopy
Gao, W., Li, N., Chen, Y., et al. (2010) · Journal of Molecular Structure · doi:10.1016/j.molstruc.2010.08.042 · Cited by 43 · see citing works
Syringin attenuates insulin resistance via adiponectin-mediated suppression of low-grade chronic inflammation and ER stress in high-fat diet-fed mice
Kim, B., Kim, M.-S., & Hyun, C. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2017.05.003 · Cited by 42 · see citing works
Interactions between herbs and antidiabetics: an overview of the mechanisms, evidence, importance, and management
Rehman, S. U., Choi, M. S., Choe, K., & Yoo, H. H. (2014) · Archives of Pharmacal Research · doi:10.1007/s12272-014-0517-z · Cited by 41 · see citing works
Effect of Asian and Siberian Ginseng on Serum Digoxin Measurement by Five Digoxin Immunoassays
Actor, J. K., Wells, A., Olsen, M., et al. (2003) · American Journal of Clinical Pathology · doi:10.1309/34bj-ecp7-uk6f-h13v · Cited by 37 · see citing works
“Recently, Li et al3 isolated a new ligand glycoside named eleutheroside E(2) from Siberian ginseng.”
Background
Immunomopharmacological effects of polysaccharides from Acanthopanax senticosus on experimental animals
Shen, M. L., Zhai, S. K., Chen, H., et al. (1991) · International Journal of Immunopharmacology · doi:10.1016/0192-0561(91)90075-i · Cited by 36 · see citing works
Natural Products and Diabetes Treatment
Gori, M., & Campbell, R. K. (1998) · The Science of Diabetes Self-Management and Care · doi:10.1177/014572179802400210 · Cited by 30 · see citing works
Effect of Brazilian, Indian, Siberian, Asian, and North American Ginseng on Serum Digoxin Measurement by Immunoassays and Binding of Digoxin-like Immunoreactive Components of Ginseng With Fab Fragment of Antidigoxin Antibody (Digibind)
Dasgupta, A., & Reyes, M. A. (2005) · American Journal of Clinical Pathology · doi:10.1309/utft-k2lh-1rmh-cbd7 · Cited by 27 · see citing works
Effect of Brazilian, Indian, Siberian, Asian, and North American Ginseng on Serum Digoxin Measurement by Immunoassays and Binding of Digoxin-like Immunoreactive Components of Ginseng With Fab Fragment of Antidigoxin Antibody (Digibind)
Dasgupta, A., & Reyes, M. A. (2005) · American Journal of Clinical Pathology · doi:10.1309/utftk2lh1rmhcbd7 · Cited by 27 · see citing works
Ginseng: Cardiotonic in adult rat cardiomyocytes, cardiotoxic in neonatal rat cardiomyocytes
Poindexter, B. J., Allison, A. W., Bick, R. J., & Dasgupta, A. (2006) · Life Sciences · doi:10.1016/j.lfs.2006.07.038 · Cited by 22 · see citing works
Lupane-glycoside ofAcanthopanax trifoliatus formatristigmatis leaves
Yook, C., Chang, S., Lai, J. H., et al. (1999) · Archives of Pharmacal Research · doi:10.1007/bf02975337 · Cited by 21 · see citing works
Naturoceutical Agents in the Management of Cardiovascular Disease
Hermann, D. D. (2002) · American Journal of Cardiovascular Drugs · doi:10.2165/00129784-200202030-00005 · Cited by 20 · see citing works
Eleutherococcus senticosus as a crude medicine: Review of biological and pharmacological effects
Yan-Lin, S., Lin-De, L., & Hong, S. (2011) · Journal of Medicinal Plants Research · doi:10.5897/jmpr.9000557 · Cited by 19 · see citing works
Role of sympathetic tone in the loss of syringin-induced plasma glucose lowering action in conscious Wistar rats
Niu, H., Hsu, F., & Liu, I.-M. (2008) · Neuroscience Letters · doi:10.1016/j.neulet.2008.08.066 · Cited by 18 · see citing works
Eleutherococcus senticosus: Studies and effects
Arouca, A. B., & Kassisse, D. M. G. (2013) · Health · doi:10.4236/health.2013.59205 · Cited by 16 · see citing works
“…SENTICOSUS The active components of Eleutherococcus senticosus, the eleutherosides, were initially coded from A to F [12], and years later, Hikino et al. (1986) [13] studied seven eleutherosides coded as A, B, C, D, E, F and G, and through acid hydrolysis of these components, obtained the…”
Method
Is ginseng free from adverse effects?
Xie, J.-T. M. (2002) · Oriental Pharmacy and Experimental Medicine · doi:10.3742/opem.2002.2.2.080 · Cited by 16 · see citing works
Eleutherococcus root: a comprehensive review of its phytochemistry and pharmacological potential in the context of its adaptogenic effect
Patyra, A., Kołtun-Jasion, M., Kupniewska, K., Parzonko, A., & Kiss, A. K. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1683795 · Cited by 10 · see citing works
Eleutherococcus Senticosus
Sonnenbora, U., & Hänsel, R. (1993) · Adverse effects of herbal drugs · doi:10.1007/978-3-642-48906-8_12 · Cited by 8 · see citing works
Cutting Propagation and Seedling Growth Effect According to Fertilizer Application of Elsholtzia minima Nakai
Kim, T.-K., Kim, H.-C., Song, J.-Y., et al. (2015) · 한국자원식물학회지 · doi:10.7732/kjpr.2015.28.2.243 · Cited by 5 · see citing works
“발근 및 뿌리생장에 대한 전처리제의 효과 발근억제 또는 저해작용을 하는 물질로는 abscisin acid, cinnamic acid, caffeic acid, phenolic acid, Tannin류 등이 있 다(Hicino et al., 1986).”
Influential
Relationship between age, size, fecundity and climatic factors in Panax wangianus an endangered medicinal plant in the sacred grove forest of North-East India
Venugopal, N., & Ahuja, P. (2011) · Journal of Forestry Research · doi:10.1007/s11676-011-0115-6 · Cited by 5 · see citing works
“…(Carpenter et al. 1982; Lewis et al. 1982; Schlessman 1985 1987), chemical composition (Shim et al. 1983; Tomoda et al. 1985; Hansen et al. 1986; Hikino et al. 1986; Oshima et al. 1987), medicinal properties (Hu 1976; Carlson 1986; Dubrick 1983) and growth, yield and rates Journal of Forestry…”
Background
The range of medicinal plants influencing mental and physical performance
Li, T. S. C. (2003) · Elsevier eBooks · doi:10.1533/9781855736900.38 · Cited by 4 · see citing works
Pflanzliche Immunstimulanzien in der Selbstmedikation
Bauer, R. (1998) · Pharmazie in unserer Zeit · doi:10.1002/pauz.19980270405 · Cited by 4 · see citing works
Selective Plant Extracts and their Combination as the Nutritional Therapeutic Remedies
Antoshechkin, A. G. (2016) · Journal of Nutritional Therapeutics · doi:10.6000/1929-5634.2016.05.01.1 · Cited by 3 · see citing works
Effectiveness of activated charcoal and equilibrium dialysis in removing Asian, American, Siberian and Indian ginseng from human serum
Dasgupta, A., & Veras, E. F. T. (2006) · Clinica Chimica Acta · doi:10.1016/j.cca.2005.12.005 · Cited by 3 · see citing works
Influence of the Plant Extract Complex “AdMax” on Global Gene Expression Levels in Cultured Human Fibroblasts
Antoshechkin, A. G., Olalde, J., Antoshechkina, M., Briuzgin, V., & Platinskiy, L. (2008) · Journal of Dietary Supplements · doi:10.1080/19390210802414337 · Cited by 3 · see citing works
Adaptogens - use, history and future
Marciniak, A., Nemeczek, S., Walczak, K., Walczak, P., MERKISZ, K., Grzybowski, J., Grzywna, N., JASKUŁA, K., & ORŁOWSKI, W. (2023) · Quality in Sport · doi:10.12775/qs.2023.09.01.002 · Cited by 3 · see citing works
Effect of Chinese Medicines Chan Su, Asian Ginseng, Siberian Ginseng, and American Ginseng on a New Digoxin Immunoassay Based on Luminescent Oxygen Channeling Technology
Dasgupta, A., Syklawer, E., Johnson, M. J., et al. (2011) · Therapeutic Drug Monitoring · doi:10.1097/ftd.0b013e3182252103 · Cited by 2 · see citing works
Acanthopanax senticosus (Rupr. et Maxim.) Harms
Tang, W., & Eisenbrand, G. (1992) · Springer eBooks · doi:10.1007/978-3-642-73739-8_1 · Cited by 2 · see citing works
Inhibitory Effects of the Extracts from Eleutherococcus senticosus Maxim. on Histamine-release from Rat's Mast Cell
Jeong, J.-H., Kim, Y. S., Baek, S., & Park, K. (2011) · 한국자원식물학회지 · doi:10.7732/kjpr.2011.24.3.324 · Cited by 1 · see citing works
“Indeed, many previous reports were also used root part for their experiments (Hikino et al., 1986; Niu et al., 2008; Davydov and Krikorian, 2000), and suggested that eleutheroside B in root bark has crucial role in various physiological disorder.”
BackgroundResult
Preparation of Ginseng Concentrate with High Content of Acidic Polysaccharide from White Tail Ginseng Marc
강태화, 박경준, & 강성태 (2004) · Journal of the Korean Society of Food Science and Nutrition · doi:10.3746/jkfn.2004.33.4.736 · Cited by 1 · see citing works
How to use the monographs
(2013) · Elsevier eBooks · doi:10.1016/b978-0-443-06992-5.00010-4 · Cited by 1 · see citing works
Nutrition, Immunity, and Alternative Medicine
Gundling, K. E., Borchers, A. T., & Gershwin, M. E. (2000) · Humana Press eBooks · doi:10.1007/978-1-59259-709-3_23
Drug Interactions with Ginkgo Biloba and Ginseng
Tholpady, A., & Risin, S. A. (2010) · doi:10.1002/9780470910108.ch15
Treatment of Diabetes Mellitus with Ginseng?
Chavez, M. L. (2001) · Journal of Herbal Pharmacotherapy · doi:10.1080/j157v01n02_09
The pharmacology of oral agents used to treat diabetes mellitus
Chan, A. W., & MacFarlane, I. A. (1988) · Practical Diabetes · doi:10.1002/pdi.1960050205
Radix Acanthopanacis senticosi Ciwujia
Wagner, H., Bauer, R., Melchart, D., Xiao, P., & Staudinger, A. (2011) · Springer eBooks · doi:10.1007/978-3-7091-0763-8_38
Short Communication: Metabolic Syndrome and Adaptogenic Nutritional Supplement “AdMax”
Antoshechkin, A. G. (2016) · Journal of Nutritional Therapeutics · doi:10.6000/1929-5634.2015.04.04.4
METHODOLOGY
Mills, E. J., Dugoua, J.-J., Perri, D., & Koren, G. (2006) · CRC Press eBooks · doi:10.1201/b13984-5
The current state of diabetes treatment
Danquah, M. K., & Jeevanandam, J. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-85396-5.00007-5
E
Blaschek, W., Hänsel, R., Keller, K., et al. (1998) · Springer eBooks · doi:10.1007/978-3-642-58928-7_5

Authors: Hikino, H., Takahashi, M., Otake, K., & Konno, C.
Venue: Journal of Natural Products
Publisher: American Chemical Society (ACS)
Published: 1986-03
Volume: 49
Issue: 2
Pages: 293-297
ISSN: 0163-3864 (ISSN-L)
1520-6025
DOI: 10.1021/np50044a015
OpenAlex: W2058055907
Cited by: 56
References: 0
Citations by year: 2025: 1 · 2023: 2 · 2022: 1 · 2021: 2 · 2017: 1 · 2016: 2 · 2015: 1 · 2014: 2 · 2013: 2
FWCI: 0.97
Type: journal article
Language: en
Open access: closed
Locations: Journal of Natural Products (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Medicinal Plants and Bioactive Compounds
Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
Keywords: Eleutherococcus senticosus, Siberian ginseng, glycans, hypoglycemic activity, alloxan-induced hyperglycemia, plasma glucose, root extract, natural product isolation
MeSH terms: Animals, Carbohydrates, Chemistry, Chromatography, DEAE-Cellulose, Electrophoresis, Paper, Electrophoresis, Polyacrylamide Gel, Panax, Hypoglycemic Agents, Male, Mice, Inbred Strains, Plants, Medicinal, Polysaccharides, Mice, Chemical Phenomena

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Isolation and Hypoglycemic Activity of Eleutherans A, B, C, D, E, F, and G: Glycans of Eleutherococcus senticosus Roots

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cited by

Related

Record

About these checks