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Sesquiterpenes from Clove (Eugenia caryophyllata) as Potential Anticarcinogenic Agents
Abstract
Bioassay-directed fractionation of clove terpenes from the plant Eugenia caryophyllata has led to the isolation of the following five active known compounds: beta-caryophyllene [1], beta-caryophyllene oxide [2], alpha-humulene [3], alpha-humulene epoxide I [4], and eugenol [5]. Their structures were determined on the basis of spectral analysis (hreims, 1H and 13C nmr). These compounds showed significant activity as inducers of the detoxifying enzyme glutathione S-transferase in the mouse liver and small intestine. The ability of natural anticarcinogens to induce detoxifying enzymes has been found to correlate with their activity in the inhibition of chemical carcinogenesis. Thus, these sesquiterpenes show promise as potential anticarcinogenic agents.
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Cited by
Shahidi, F., & Ambigaipalan, P. (2015) · Journal of Functional Foods · doi:10.1016/j.jff.2015.06.018 · Cited by 3,081
Chaieb, K., Hajlaoui, H., Zmantar, T., Kahla‐Nakbi, A. B., Rouabhia, M., Mahdouani, K., & Bakhrouf, A. (2007) · Phytotherapy Research · doi:10.1002/ptr.2124 · Cited by 934
β‐caryophyllene and β‐caryophyllene oxide—natural compounds of anticancer and analgesic properties
Fidyt, K., Fiedorowicz, A., Strządała, L., & Szumny, A. (2016) · Cancer Medicine · doi:10.1002/cam4.816 · Cited by 674
Lee, K.-G., & Shibamoto, T. (2001) · Food Chemistry · doi:10.1016/s0308-8146(01)00161-3 · Cited by 400
CRAIG, W. J. (1997) · Journal of the American Dietetic Association · doi:10.1016/s0002-8223(97)00765-7 · Cited by 318
Metadata
- Authors
- Zheng, G.-Q., Kenney, P. M., & Lam, L. K. T.
- Venue
- Journal of Natural Products
- Publisher
- American Chemical Society (ACS)
- Published
- 1992-07
- Volume
- 55
- Issue
- 7
- Pages
- 999-1003
- ISSN
- 0163-3864 (ISSN-L)
- 1520-6025
- OpenAlex
- W2042644050
- Cited by
- 346
- References
- 0
- FWCI
- 1.22
- Type
- journal article
- Language
- en
- Open access
- closed
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- Zheng, G.-Q., Kenney, P. M., & Lam, L. K. T. (1992). Sesquiterpenes from Clove (Eugenia caryophyllata) as Potential Anticarcinogenic Agents. Journal of Natural Products. https://doi.org/10.1021/np50085a029
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