Phenolics and polyphenolics in foods, beverages and spices: Antioxidant activity and health effects –A review
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This review reports on the latest research results and applications of phenolic and polyphenolic compounds. Phenolic compounds, ubiquitous in plants, are an essential part of the human diet and are of considerable interest due to their antioxidant properties and potential beneficial health effects. These compounds range structurally from a simple phenolic molecule to complex high-molecular-weight polymers. There is increasing evidence that consumption of a variety of phenolic compounds present in foods may lower the risk of health disorders because of their antioxidant activity. When added to foods, antioxidants control rancidity development, retard the formation of toxic oxidation products, maintain nutritional quality, and extend the shelf-life of products. Due to safety concerns and limitation on the use of synthetic antioxidants, natural antioxidants obtained from edible materials, edible by-products and residual sources have been of increasing interest. This contribution summarizes both the synthetic and natural phenolic antioxidants, emphasizing their mode of action, health effects, degradation products and toxicology. In addition, sources of phenolic antioxidants are discussed in detail.
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Polyphenols exhibit anti-inflammatory, antibacterial, antifungal, antiviral, antiallergic, anticancer and anticoagulant properties.
“They exhibit anti-inflammatory, antibacterial, antifungal, antiviral, antiallergic, anticancer and anticoagulant properties [190,191,192,193,197].”
From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [192]
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“Phenolic acids als have the ability t inactivate radicals by mo oel ctr nic transfer, and s me can chelate the transition metals involved in the Fento reaction thus preventing the formation of the highly reactive hydroxyl radical [55,56].”
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“While research often focuses on isolated phenolic compounds as potential additives (as they are well-known, potent antioxidants and generally account for low toxicity), these same compounds are present at proper concentrations in EOs extracted from plants and thus can be used to provide extra properties to biodegradab…”
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“Many exogenous small molecule antioxidants such as polyphenols [18,19] are commonly isolated from a broad variety of plants [20], and their potency is extensively studied [21–27]; however, their bioavailability is frequently poor [28,29].”
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Biodegradable active, intelligent, and smart packaging materials for food applications
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New Advances in Metabolic Syndrome, from Prevention to Treatment: The Role of Diet and Food
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“Compared to organic antioxidants, natural products present better biosafety during treatment [9,10].”
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de Camargo, A. C., Regitano-D’Arce, M. A. B., Rasera, G. B., Canniatti‐Brazaca, S. G., do Prado‐Silva, L., Alvarenga, V. O., Sant’Ana, A. S., & Shahidi, F. (2017) · Food Chemistry · doi:10.1016/j.foodchem.2017.05.046 · Cited by 201 · see citing works
Polyphenols and their potential role to fight viral diseases: An overview
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“Therefore, polyphenols are widely promoted to be used as functional foods or in drugs preparations accepted for human consumption around the world (Cheynier, 2012; Shahidi and Ambigaipalan, 2015; Cory et al., 2018).”
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Natural antioxidants in processing and storage stability of sheep and goat meat products
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Food flavonols: Nutraceuticals with complex health benefits and functionalities
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“Various types of polyphenols are present in plant-based foods, which vary in their levels, physicochemical characteristics, and nutritional effects (Shahidi and Ambigaipalan 2015).”
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“Today, almost all processed foods contain synthetic antioxidants and, despite being reported safe in the past, several studies have addressed their danger for human health, among which liver, kidney, and lungs damages, mutagenesis, carcinogenesis, and many others [19].”
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Scalable biocatalytic C–H oxyfunctionalization reactions
Chakrabarty, S., Wang, Y., Perkins, J. C., & Narayan, A. R. H. (2020) · Chemical Society Reviews · doi:10.1039/d0cs00440e · Cited by 180 · see citing works
Biochemistry of Antioxidants: Mechanisms and Pharmaceutical Applications
Losada‐Barreiro, S., Bayındır, Z. S., Paiva‐Martins, F., & Bravo‐Díaz, C. (2022) · Biomedicines · doi:10.3390/biomedicines10123051 · Cited by 178 · see citing works
Mocan, A., Zengin, G., Simirgiotis, M. J., Schafberg, M., Mollica, A., Vodnar, D. C., Crișan, G., & Rohn, S. (2017) · Journal of Enzyme Inhibition and Medicinal Chemistry · doi:10.1080/14756366.2016.1243535 · Cited by 177 · see citing works
de Camargo, A. C., Regitano-D’Arce, M. A. B., Biasoto, A. C. T., & Shahidi, F. (2016) · Food Chemistry · doi:10.1016/j.foodchem.2016.05.047 · Cited by 176 · see citing works
Biochemical and Structural Analysis of Substrate Specificity of a Phenylalanine Ammonia-Lyase
Jun, S., Sattler, S. A., Cortez, G. S., Vermerris, W., Sattler, S. E., & Kang, C. (2017) · PLANT PHYSIOLOGY · doi:10.1104/pp.17.01608 · Cited by 174 · see citing works
Arvaniti, O. S., Samaras, Y., Gatidou, G., Τhomaidis, Ν. S., & Stasinakis, A. S. (2019) · Food Research International · doi:10.1016/j.foodres.2019.01.055 · Cited by 173 · see citing works
Lü, F., Kuhnle, G. K., & Cheng, Q. (2018) · Food Control · doi:10.1016/j.foodcont.2018.05.018 · Cited by 171 · see citing works
Yan, C., Jin, J., Wang, J., Zhang, F., Tian, Y., Liu, C., Zhang, F., Cao, L., Zhou, Y., & Han, Q. (2021) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2022.214595 · Cited by 171 · see citing works
Ge, S., Duo, L., Wang, J., GegenZhula, Yang, J., Li, Z., & Tu, Y. (2021) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2021.113877 · Cited by 168 · see citing works
Moazzen, A., Öztinen, N., Ak-sakallı, E., & Koşar, M. (2022) · Heliyon · doi:10.1016/j.heliyon.2022.e10467 · Cited by 167 · see citing works
“ABTS þ radical cation decolorization assay and 2,2-diphenyl-1-picrylhydrazyl (DPPH ) radical scavenging assay are methods that are based on electron donation of antioxidants to reduce the radical (Shahidi and Ambigaipalan, 2015).”
MethodIsmail, B. B., Pu, Y., Guo, M., Ma, X., & Liu, D. (2018) · Food Chemistry · doi:10.1016/j.foodchem.2018.10.056 · Cited by 166 · see citing works
Bener, M., Şen, F. B., Önem, A. N., Bekdeşer, B., Çeli̇k, S. E., Lalikoğlu, M., Aşçı, Y. S., Çapanoğlu, E., & Apak, R. (2022) · Food Chemistry · doi:10.1016/j.foodchem.2022.132633 · Cited by 169 · see citing works
Fruit Juice Industry Wastes as a Source of Bioactives
Kandemir, K., Piskin, E., Xiao, J., Tomaş, M., & Çapanoğlu, E. (2022) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.2c00756 · Cited by 172 · see citing works
Phenolic compounds in agri-food by-products, their bioavailability and health effects
Shahidi, F., Vamadevan, V., Oh, W. Y., & Peng, H. (2019) · Journal of Food Bioactives · doi:10.31665/jfb.2019.5178 · Cited by 166 · see citing works
Martinez-Gomez, A., Caballero, I., & Blanco, C. A. (2020) · Biomolecules · doi:10.3390/biom10030400 · Cited by 164 · see citing works
“The classification of the different phenols is done according to their structure, so we have phenolics acids, flavonoids, stilbenes, coumarins, lignans, tannins, chalcones flavonols, flavononols, flavones, flavanols, flavanones, anthocyanidins and isoflavonoids [49,50].”
BackgroundNatural Antioxidant Evaluation: A Review of Detection Methods
Mendonça, J. D. S., Guimarães, R. D. C. A., Zorgetto-Pinheiro, V. A., Fernandes, C. D. P., Marcelino, G., Bogo, D., Freitas, K. D. C., Hiane, P. A., Melo, E. S. D. P., Vilela, M. L. B., et al. (2022) · Molecules · doi:10.3390/molecules27113563 · Cited by 164 · see citing works
- Authors
- Shahidi, F., & Ambigaipalan, P.
- Affiliations
- Memorial University of Newfoundland (CA)
- Corresponding author
- Shahidi, Fereidoon
- Venue
- Journal of Functional Foods
- Publisher
- Elsevier BV
- Published
- 2015-10
- Volume
- 18
- Pages
- 820-897
- ISSN
- 1756-4646 (ISSN-L)
- OpenAlex
- W1174839022
- Cited by
- 3,081
- References
- 950
- Citations by year
- 2026: 376 · 2025: 283 · 2024: 293 · 2023: 315 · 2022: 355 · 2021: 413 · 2020: 314 · 2019: 283 · 2018: 209 · 2017: 144 · 2016: 86 · 2015: 8 · 2014: 1
- FWCI
- 102.36
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Functional Foods (publishedVersion, cc-by-nc-nd)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Physical Sciences › Chemistry › Organic Chemistry › Edible Oils Quality and Analysis
- Physical Sciences › Chemistry › Organic Chemistry › Free Radicals and Antioxidants
- Keywords
- phenolic compounds, polyphenols, antioxidant activity, natural antioxidants, synthetic antioxidants, dietary antioxidants, beverages, spices, health effects, oxidative degradation products, toxicology, shelf life extension, rancidity prevention, functional foods
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