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Isolation and Structure Elucidation of New Nitrile and Mustard Oil Glycosides from Moringa oleifera and Their Effect on Blood Pressure
Abstract
Bioassay-guided analysis of an EtOH extract of Moringa oleifera leaves showing hypotensive activity led to the isolation of two nitrile glycosides, niazirin [1] and niazirinin [2], and three mustard oil glycosides, 4-[(4'-O-acetyl-alpha-L-rhamnosyloxy)benzyl]isothiocyanate [4], niaziminin A, and niaziminin B. Glycoside 2 is a new compound. Niaziminins A and B have previously been obtained from the left extract as a mixture, while compound 4 is new from this source. Structural determination was accomplished by means of spectroscopic methods including appropriate 2D nmr experiments and chemical reactions. This is the first report of the isolation of nitriles, an isothiocyanate, and thiocarbamates from the same plant species. Isothiocyanate 4 and the thiocarbamate glycosides niaziminin A and B showed hypotensive activity while nitrile glycosides 1 and 2 were found to be inactive in this regard.
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Citations
Cited by
Moringa oleifera : a food plant with multiple medicinal uses
Anwar, F., Latif, S., Ashraf, M., & Gilani, A. H. (2007) · Phytotherapy Research · doi:10.1002/ptr.2023 · Cited by 1,657
Self-citationBennett, R. N., Mellon, F. A., Foidl, N., Pratt, J. H., Dupont, M. S., Perkins, L., & Kroon, P. A. (2003) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf0211480 · Cited by 444
Singh, B. N., Singh, B. R., Singh, R. L., Prakash, D., Dhakarey, R., Upadhyay, G., & Singh, H. B. (2009) · Food and Chemical Toxicology · doi:10.1016/j.fct.2009.01.034 · Cited by 425
Antiproliferation and induction of apoptosis by Moringa oleifera leaf extract on human cancer cells
Sreelatha, S., Jeyachitra, A., & Padma, P. R. (2011) · Food and Chemical Toxicology · doi:10.1016/j.fct.2011.03.006 · Cited by 334
Ma, Z. F., Ahmad, J., Zhang, H., Khan, I., & Muhammad, S. (2020) · South African Journal of Botany · doi:10.1016/j.sajb.2018.12.002 · Cited by 257
Metadata
- Authors
- Faizi, S., Siddiqui, B. S., Saleem, R., Siddiqui, S., Aftab, K., & Gilani, A.-U. H.
- Venue
- Journal of Natural Products
- Publisher
- American Chemical Society (ACS)
- Published
- 1994-09
- Volume
- 57
- Issue
- 9
- Pages
- 1256-1261
- ISSN
- 0163-3864 (ISSN-L)
- 1520-6025
- OpenAlex
- W2037294472
- Cited by
- 253
- References
- 0
- FWCI
- 2.46
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Isolation and Structure Elucidation of New Nitrile and Mustard Oil Glycosides from Moringa oleifera and Their Effect on Blood Pressure. https://app.cochat.ai/papers/10.1021/np50111a011
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- Faizi, S., Siddiqui, B. S., Saleem, R., Siddiqui, S., Aftab, K., & Gilani, A.-U. H. (1994). Isolation and Structure Elucidation of New Nitrile and Mustard Oil Glycosides from Moringa oleifera and Their Effect on Blood Pressure. Journal of Natural Products. https://doi.org/10.1021/np50111a011
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