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Novel Tricyclic Diterpenoids from Euphorbia micractina
Abstract
From the Me(2)CO extract of the whole plant of Euphorbia micractina, four new diterpenoids with a novel carbon skeleton, euphactins A-D [1-4], have been isolated. Their structures were elucidated by spectroscopic methods including 2D nmr techniques and X-ray crystallographic analysis.
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Anthracyclines exert antitumor activity mainly by inhibiting topoisomerase II.
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From Marine Natural Products: A Source of Novel Anticancer Drugs (2019) · cites this paper as [216]
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BindingDB Entry 50031306: Chemical Constituents of the Roots of Euphorbia micractina.
BindingDB (2010) · UC San Diego · doi:10.7270/q2ht2pfd
Metadata
- Authors
- Shi, J.-G., Jia, Z.-J., & Cui, Y.-X.
- Venue
- Journal of Natural Products
- Publisher
- American Chemical Society (ACS)
- Published
- 1995-01
- Volume
- 58
- Issue
- 1
- Pages
- 51-56
- ISSN
- 0163-3864 (ISSN-L)
- 1520-6025
- OpenAlex
- W2064745628
- Cited by
- 18
- References
- 0
- Citations by year
- 2019: 3 · 2018: 1 · 2015: 1 · 2014: 1 · 2013: 1
- FWCI
- 0.37
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Natural Products (publishedVersion)
- Lanzhou University Institutional Repository (submittedVersion)
- Funders
- National Science Foundation
- Topics
- Physical Sciences › Chemistry › Organic Chemistry › Bioactive Natural Diterpenoids Research
- Physical Sciences › Chemistry › Organic Chemistry › Biological Activity of Diterpenoids and Biflavonoids
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Drug Discovery › Phytochemical compounds biological activities
- Keywords
- tricyclic diterpenoids, novel carbon skeleton, structure elucidation, natural product isolation, plant secondary metabolites
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