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Novel Bioactivities of Curcuma longa Constituents
Abstract
Bioassay-directed fractionation of ethyl acetate extract from Curcuma longa Linn. rhizomes yielded three curcuminoids, which displayed topoisomerase I and II enzyme inhibition activity. Curcumin III (3) was the most active curcuminoid, inhibiting topoisomerase at 25 micrograms mL-1. Curcumin I (1) and curcumin II (2) inhibited the topoisomerases at 50 micrograms mL-1. Fractionation of the volatile oil from the rhizomes afforded ar-turmerone (4), which displayed mosquitocidal activity with an LD100 of 50 micrograms mL-1 on Aedes aegyptii larvae. Bioassay-directed fractionation of hexane extract from the turmeric leaves yielded labda-8(17),12-diene-15,16 dial (5) with antifungal activity against Candida albicans at 1 micrograms mL-1 and inhibited the growth of Candida kruseii and Candida parapsilosis at 25 micrograms mL-1. In addition, 5 displayed 100% mosquitocidal activity on A. aegyptii larvae at 10 micrograms mL-1.
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Cited by
CURCUMIN: THE INDIAN SOLID GOLD
Aggarwal, B. B., Sundaram, C., Malani, N., & Ichikawa, H. (2007) · ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY · doi:10.1007/978-0-387-46401-5_1 · Cited by 1,647
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Chainani-Wu, N. (2003) · The Journal of Alternative and Complementary Medicine · doi:10.1089/107555303321223035 · Cited by 1,106
Sandur, S. K., Pandey, M. K., Sung, B., Ahn, K. S., Murakami, A., Sethi, G., Limtrakul, P., Badmaev, V., & Aggarwal, B. B. (2007) · Carcinogenesis · doi:10.1093/carcin/bgm123 · Cited by 687
Surh, Y.-J. (1999) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/s1383-5742(99)00057-5 · Cited by 633
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Shaalan, E. A.-S., Canyon, D., Younes, M. W. F., Abdel-Wahab, H., & Mansour, A.-H. (2005) · Environment International · doi:10.1016/j.envint.2005.03.003 · Cited by 621
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Cytotoxicity, antioxidant and anti-inflammatory activities of Curcumins I–III from Curcuma longa
Ramsewak, R. S., DeWitt, D. L., & Nair, M. G. (2000) · Phytomedicine · doi:10.1016/s0944-7113(00)80048-3 · Cited by 302
Self-citationSrivastava, S., Saksena, A. K., Khattri, S., Kumar, S., & Dagur, R. S. (2016) · Inflammopharmacology · doi:10.1007/s10787-016-0289-9 · Cited by 143
Metadata
- Authors
- Roth, G. N., Chandra, A., & Nair, M. G.
- Venue
- Journal of Natural Products
- Publisher
- American Chemical Society (ACS)
- Published
- 1998-03-31
- Volume
- 61
- Issue
- 4
- Pages
- 542-545
- ISSN
- 0163-3864 (ISSN-L)
- 1520-6025
- OpenAlex
- W2061317234
- Cited by
- 230
- References
- 0
- FWCI
- 2.83
- Type
- journal article
- Language
- en
- Open access
- closed
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