Molecular mechanisms of chemopreventive effects of selected dietary and medicinal phenolic substances

Surh, Young-Joon

doi:10.1016/s1383-5742(99)00057-5

Cited by 633Phytochemicals and Antioxidant ActivitiesBioactive natural compoundsCurcumin's Biomedical Applications

Molecular mechanisms of chemopreventive effects of selected dietary and medicinal phenolic substances

Surh, Young-Joon·1999·Mutation research. Fundamental and molecular mechanisms of mutagenesis

DOI 10.1016/s1383-5742(99)00057-5

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Abstract

Recently, considerable attention has been focused on identifying naturally occurring chemopreventive substances capable of inhibiting, retarding, or reversing the multi-stage carcinogenesis. A wide array of phenolic substances, particularly those present in dietary and medicinal plants, have been reported to possess substantial anticarcinogenic and antimutagenic activities. The majority of these naturally occurring phenolics retain antioxidative and anti-inflammatory properties which appear to contribute to their chemopreventive or chemoprotective activity. Capsaicin (trans-8-methyl-N-vanillyl-6-nonenamide), a pungent ingredient of hot chili pepper, protects against experimentally-induced mutagenesis and tumorigenesis. It also induces apoptosis in various immortalized or malignant cell lines. Plants of ginger family (Zingiberaceae) have been frequently and widely used as spices and also, in traditional oriental medicine. Curcumin, a yellow ingredient from turmeric (Curcuma longa L., Zingiberaceae), has been extensively investigated for its cancer chemopreventive potential. Yakuchinone A [1-(4'-hydroxy-3'-methoxyphenyl)-7-phenyl-3-heptanone] and yakuchinone B [1-(4'-hydroxy-3'-methoxyphenyl)-7-phenylhept-1-en-3-one] present in Alpinia oxyphylla Miquel (Zingiberaceae) have inhibitory effects on phorbol ester-induced inflammation and skin carcinogenesis in mice, and oxidative stress in vitro. These diarylheptanoids suppress phorbol ester-induced activation of ornithine decarboxylase and production of tumor necrosis factor-alpha or interleukin-1alpha and their mRNA expression. They also nullified the phorbol ester-stimulated induction of activator protein 1 (AP-1) in cultured human promyelocytic leukemia (HL-60) cells. In addition, both yakuchinone A and B induced apoptotic death in HL-60 cells. Ginger (Zingiber officinale Roscoe, Zingiberaceae) contains such pungent ingredients as [6]-gingerol and [6]-paradol, which also have anti-tumor promotional and antiproliferative effects. Resveratrol (3, 5,4'-trihydroxy-trans-stilbene), a phytoalexin found in grapes and other dietary and medicinal plants, and (-)-epigallocatechin gallate, a major antioxidative green tea polyphenol, exert striking inhibitory effects on diverse cellular events associated with multi-stage carcinogenesis. In addition, these compounds have ability to suppress proliferation of human cancer cells via induction of apoptosis.

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Cancer preventive compounds may stimulate anticancer immunity, inhibit inflammation, angiogenesis and tumor invasion, or protect from UV-radiation damage.
“Cancer preventive compounds may stimulate anticancer immunity, inhibit inflammation, angiogenesis and tumor invasion, or protect from UV-radiation damage [144,145,146,147].”
From Anticancer and Cancer Preventive Properties of Marine Polysaccharides: Some Results and Prospects (2013) · cites this paper as [144]

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Authors: Surh, Y.-J.
Affiliations: Seoul National University (KR)
Corresponding author: Surh, Young-Joon
ORCID: Surh, Young-Joon
Venue: Mutation research. Fundamental and molecular mechanisms of mutagenesis
Publisher: Elsevier BV
Published: 1999-07
Volume: 428
Issue: 1-2
Pages: 305-327
ISSN: 0027-5107 (ISSN-L)
1386-1964
DOI: 10.1016/s1383-5742(99)00057-5
OpenAlex: W2081093364
Cited by: 633
References: 237
Citations by year: 2025: 5 · 2024: 12 · 2023: 7 · 2022: 10 · 2021: 9 · 2020: 13 · 2019: 20 · 2018: 30 · 2017: 23 · 2016: 23 · 2015: 19 · 2014: 26 · 2013: 23 · 2012: 35
FWCI: 2.32
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Mutation research. Fundamental and molecular mechanisms of mutagenesis (publishedVersion)
PubMed (publishedVersion)
Seoul National University Open Repository (Seoul National University) (submittedVersion)
Funders: Ministry of Health and Welfare
Korea Science and Engineering Foundation
Seoul National University (HMP-96-D-2-1034)
Topics: Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bioactive natural compounds
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Curcumin's Biomedical Applications
Keywords: chemoprevention, phenolic compounds, dietary phytochemicals, medicinal plants, capsaicin, curcumin, diarylheptanoids, ginger, resveratrol, epigallocatechin gallate, apoptosis, oxidative stress, anti-inflammatory activity, anticarcinogenic activity, ornithine decarboxylase
MeSH terms: Resveratrol, Animals, Capsaicin, Catechin, Catechols, Curcumin, Diet, Fatty Alcohols, Humans, Neoplasms, Neoplasms, Experimental, Phenols, Plants, Edible, Plants, Medicinal, Stilbenes, Mice

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Molecular mechanisms of chemopreventive effects of selected dietary and medicinal phenolic substances

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