The DOI matches its Crossref record.
The Cytosporones, New Octaketide Antibiotics Isolated from an Endophytic Fungus
Abstract
[structure] Organic extracts from cultures of endophytic fungi collected in the Guanacaste Conservation Area of Costa Rica were screened for antibiotic activity. Two endophytes CR200 (Cytospora sp.) and CR146 (Diaporthe sp.) were found to have potent antibiotic activity. Bioassay-guided fractionation of the extracts from these fungi led to the identification of cytosporones D and E, antibacterial active trihydroxybenzene lactones, and three related but inactive metabolites. The five new octaketides were characterized using X-ray crystallography and NMR.
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Citations
Cited by
Gunatilaka, A. A. L. (2006) · Journal of Natural Products · doi:10.1021/np058128n · Cited by 1,032
Heterogeneous Catalysis for Tandem Reactions
Climent, M. J., Corma, A., Iborra, S., & Sabater, M. J. (2014) · ACS Catalysis · doi:10.1021/cs401052k · Cited by 361
Natural Products as Fungicide and Their Role in Crop Protection
Santra, H. K., & Banerjee, D. (2020) · Natural Bioactive Products in Sustainable Agriculture · doi:10.1007/978-981-15-3024-1_9 · Cited by 90
Metadata
- Authors
- Brady, S. F., Wagenaar, M. M., Singh, M. P., Janso, J. E., & Clardy, J.
- Venue
- Organic Letters
- Publisher
- American Chemical Society (ACS)
- Published
- 2000-11-22
- Volume
- 2
- Issue
- 25
- Pages
- 4043-4046
- ISSN
- 1523-7052 (ISSN-L)
- 1523-7060
- OpenAlex
- W2952225583
- Cited by
- 203
- References
- 0
- FWCI
- 0.83
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: The Cytosporones, New Octaketide Antibiotics Isolated from an Endophytic Fungus. https://app.cochat.ai/papers/10.1021/ol006680s
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- Brady, S. F., Wagenaar, M. M., Singh, M. P., Janso, J. E., & Clardy, J. (2000). The Cytosporones, New Octaketide Antibiotics Isolated from an Endophytic Fungus. Organic Letters. https://doi.org/10.1021/ol006680s
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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