Enantioselective synthesis of Janus kinase inhibitor INCB018424 via an organocatalytic aza-Michael reaction

Lin, Qiyan, Meloni, David, Pan, Yongchun, Xia, Michael, Rodgers, James, Shepard, Stacey, Li, Mei, Galya, Laurine +4 more·2009·Organic Letters
DOI 10.1021/ol900350k

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  66. Additional file 7 of N6-methyladenosine modification positively regulate Japanese encephalitis virus replication
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  68. Additional file 3 of N6-methyladenosine modification positively regulate Japanese encephalitis virus replication
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  78. BindingDB Entry 50034482: Discovery of kinase spectrum selective macrocycle (16E)-14-methyl-20-oxa-5,7,14,26-tetraazatetracyclo[19.3.1.1(2,6).1(8,12)]heptacosa-1(25),2(26),3,5,8(27),9,11,16,21,23-decaene (SB1317/TG02), a potent inhibitor of cyclin dependent kinases (CDKs), Janus kinase 2 (JAK2), and fms-like tyrosine kinase
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  79. BindingDB Entry 50017048: Small Molecule Kinase Inhibitor Drugs (1995-2021): Medical Indication, Pharmacology, and Synthesis.
    BindingDB · 2023 · UC San Diego
  80. BindingDB Entry 50047435: Design, synthesis and preliminary biological evaluation of 4-aminopyrazole derivatives as novel and potent JAKs inhibitors.
    BindingDB · 2017 · UC San Diego
  81. BindingDB Entry 50040914: Structure-based discovery of C-2 substituted imidazo-pyrrolopyridine JAK1 inhibitors with improved selectivity over JAK2.
    BindingDB · 2013 · UC San Diego
  82. BindingDB Entry 50020989: Synthesis and clinical application of small-molecule inhibitors of Janus kinase.
    BindingDB · 2025 · UC San Diego
  83. BindingDB Entry 50014226: The synthesis and bioactivity of pyrrolo[2,3-d]pyrimidine derivatives as tyrosine kinase inhibitors for NSCLC cells with EGFR mutations.
    BindingDB · 2022 · UC San Diego
  84. BindingDB Entry 50040407: Discovery and optimization of C-2 methyl imidazopyrrolopyridines as potent and orally bioavailable JAK1 inhibitors with selectivity over JAK2.
    BindingDB · 2013 · UC San Diego