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Cited by 238

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Highly Enantioselective Alkylation Reaction of Enamides by Brønsted-Acid Catalysis

Guo, Qi-Xiang, Peng, Yun-Gui, Zhang, Jin-Wei, Song, Liu, Feng, Zhang, Gong, Liu-Zhu·2009·Organic Letters

Abstract

The H8-BINOL-derived, phosphoric acid catalyzed, highly enatioselective alkylation reaction of enamides with indolyl alcohols has been described. A phosphoric acid derived from H8-BINOL enabled an asymmetric alpha-alkylation of enamides with indolyl alcohols to give beta-aryl 3-(3-indolyl)propanones in high yields (up to 96%) and with excellent enantioselectivity (up to 96% ee).

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Metadata

Authors
Guo, Q.-X., Peng, Y.-G., Zhang, J.-W., Song, L., Feng, Z., & Gong, L.-Z.
Venue
Organic Letters
Published
2009-09-11
Volume
11
Issue
20
Pages
4620-4623
ISSN
  • 1523-7052 (ISSN-L)
  • 1523-7060
OpenAlex
W2081048890
Cited by
238
References
0
FWCI
10.70
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Highly Enantioselective Alkylation Reaction of Enamides by Brønsted-Acid Catalysis. https://app.cochat.ai/papers/10.1021/ol901892s
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Guo, Q.-X., Peng, Y.-G., Zhang, J.-W., Song, L., Feng, Z., & Gong, L.-Z. (2009). Highly Enantioselective Alkylation Reaction of Enamides by Brønsted-Acid Catalysis. Organic Letters. https://doi.org/10.1021/ol901892s

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