The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Managing Solids in Microreactors for the Upstream Continuous Processing of Fine Chemicals
Abstract
The management of solid compounds is a major challenge facing the upstream, continuous processing of pharmaceuticals and fine chemicals. Many reactions relevant to fine chemical production either react with or form insoluble materials, which become problematic in continuous flow microreactors. The deposition, growth, or bridging of compounds can limit fluid flow from the micro- to the mesoscale, and thereby render continuous reactors inoperable. A comprehensive approach for managing solids consists of solids identification, the development of the root failure mechanism(s), and the application of active and passive techniques for the prevention and remediation. This review examines the basic principles of microreactor design for reactions that involve solids, toward the goal of performing the continuous flow processing of fine chemicals.
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Citations
Cites
The origins and the future of microfluidics
Whitesides, G. M. (2006) · Nature · doi:10.1038/nature05058 · Cited by 9,687
Microchemical systems for continuous-flow synthesis
Hartman, R. L., & Jensen, K. F. (2009) · Lab on a Chip · doi:10.1039/b906343a · Cited by 508
Self-citation
Cited by
The Hitchhiker’s Guide to Flow Chemistry
Plutschack, M. B., Pieber, B., Gilmore, K., & Seeberger, P. H. (2017) · Chemical Reviews · doi:10.1021/acs.chemrev.7b00183 · Cited by 1,995
Flow chemistry syntheses of natural products
Pastre, J. C., Browne, D. L., & Ley, S. V. (2013) · Chemical Society Reviews · doi:10.1039/c3cs60246j · Cited by 658
Flow chemistry—Microreaction technology comes of age
Jensen, K. F. (2017) · AIChE Journal · doi:10.1002/aic.15642 · Cited by 508
Metadata
- Authors
- Hartman, R. L.
- Venue
- Organic Process Research & Development
- Publisher
- American Chemical Society (ACS)
- Published
- 2012-04-16
- Volume
- 16
- Issue
- 5
- Pages
- 870-887
- ISSN
- 1083-6160 (ISSN-L)
- 1520-586X
- OpenAlex
- W2072567782
- Cited by
- 260
- References
- 2
- FWCI
- 11.16
- Type
- journal article
- Language
- en
- Open access
- closed
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