The DOI matches its Crossref record.
Processing of Serum Proteins Underlies the Mass Spectral Fingerprinting of Myocardial Infarction
Abstract
The MALDI-TOF spectra of peptides from the sera of normal and myocardial infarction patients produced patterns that provided an accurate diagnostic of MI. In myocardial infarction, the spectral pattern originated from the cleavage of complement C3 alpha chain to release the C3f peptide and cleavage of fibrinogen to release peptide A. The fibrinogen peptide A and complement C3f peptide were in turn progressively truncated by aminopeptidases to produce two families of fragments that formed the characteristic spectral pattern of MI. Time course and inhibitor studies demonstrated that the peptide patterns in the serum reflect the balance of disease-specific-protease and aminopeptidase activity ex vivo.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Mass Spectrometry as a Diagnostic and a Cancer Biomarker Discovery Tool
Diamandis, E. P. (2004) · Molecular & Cellular Proteomics · doi:10.1074/mcp.r400007-mcp200 · Cited by 631
Stenvinkel, P., Carrero, J. J. A. A., Axelsson, J., Lindholm, B., Heimbu[Combining Diaeresis]rger, O., & Massy, Z. (2008) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.03670807 · Cited by 561
Progress and Challenges in Screening for Early Detection of Ovarian Cancer
Jacobs, I. J., & Menon, U. (2004) · Molecular & Cellular Proteomics · doi:10.1074/mcp.r400006-mcp200 · Cited by 458
DeSouza, L., Diehl, G., Rodrigues, M. J., Guo, J., Romaschin, A. D., Colgan, T. J., & Siu, K. W. M. (2005) · Journal of Proteome Research · doi:10.1021/pr049821j · Cited by 362
The MALDI-TOF Mass Spectrometric View of the Plasma Proteome and Peptidome
Hortin, G. L. (2006) · Clinical Chemistry · doi:10.1373/clinchem.2006.069252 · Cited by 351
Practical Points in Urinary Proteomics
Thongboonkerd, V. (2007) · Journal of Proteome Research · doi:10.1021/pr070328s · Cited by 208
Metadata
- Authors
- Marshall, J., Kupchak, P., Zhu, W., Yantha, J., Vrees, T., Furesz, S., Jacks, K., Smith, C., Kireeva, I., Zhang, R., Takahashi, M., Stanton, E., & Jackowski, G.
- Venue
- Journal of Proteome Research
- Publisher
- American Chemical Society (ACS)
- Published
- 2003-05-14
- Volume
- 2
- Issue
- 4
- Pages
- 361-372
- ISSN
- 1535-3893 (ISSN-L)
- 1535-3907
- OpenAlex
- W2055118323
- Cited by
- 229
- References
- 0
- FWCI
- 7.57
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
