The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Precise Characterization of Human Histones in the H2A Gene Family by Top Down Mass Spectrometry
Abstract
Top Down analysis revealed that at least fourteen genes encoding histone H2A are coexpressed in HeLa cells. Characterization of these species 1 revealed that all except H2A.Z and H2A.F/Z were α- N -acetylated, H2A.O and H2A.C,D,I,N,P were the most abundant, and those exceeding ∼10% abundance lacked post-translational modifications. This unequivocal identification of H2A forms illustrates the advantages of Top Down Mass Spectrometry and provides a global perspective of H2A regulation through the cell cycle. Keywords: histone H2A • Fourier transform mass spectrometry (FTMS) • Top Down • post-translational modification (PTM) • SILAC • cell cycle • ubiquitination • electron capture dissociation (ECD) • histone code • chromatin
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Cites
Histone acetylation in chromatin structure and transcription
Grunstein, M. (1997) · Nature · doi:10.1038/38664 · Cited by 2,884
Cited by
Lysine propionylation and butyrylation are novel post-translational modifications in histones
Chen, Y., Sprung, R., Tang, Y., Ball, H., Sangras, B., Kim, S. C., Falck, J. R., Peng, J., Gu, W., & Zhao, Y. (2007) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m700021-mcp200 · Cited by 764
Mapping intact protein isoforms in discovery mode using top-down proteomics
Tran, J. C., Zamdborg, L., Ahlf, D. R., Lee, J. E., Catherman, A. D., Durbin, K. R., Tipton, J. D., Vellaichamy, A., Kellie, J. F., Li, M., et al. (2011) · Nature · doi:10.1038/nature10575 · Cited by 665
Self-citationProgress in Top-Down Proteomics and the Analysis of Proteoforms
Toby, T. K., Fornelli, L., & Kelleher, N. L. (2016) · Annual Review of Analytical Chemistry · doi:10.1146/annurev-anchem-071015-041550 · Cited by 576
Self-citationDecoding protein modifications using top-down mass spectrometry
Siuti, N., & Kelleher, N. L. (2007) · Nature Methods · doi:10.1038/nmeth1097 · Cited by 503
Self-citationMass Spectrometry-Based Detection and Assignment of Protein Posttranslational Modifications
Doll, S., & Burlingame, A. L. (2015) · ACS Chemical Biology · doi:10.1021/cb500904b · Cited by 261
Metadata
- Authors
- Boyne, M. T., Pesavento, J. J., Mizzen, C. A., & Kelleher, N. L.
- Venue
- Journal of Proteome Research
- Publisher
- American Chemical Society (ACS)
- Published
- 2006-01-10
- Volume
- 5
- Issue
- 2
- Pages
- 248-253
- ISSN
- 1535-3893 (ISSN-L)
- 1535-3907
- OpenAlex
- W2003650751
- Cited by
- 158
- References
- 1
- FWCI
- 8.14
- Type
- journal article
- Language
- en
- Open access
- closed
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- Boyne, M. T., Pesavento, J. J., Mizzen, C. A., & Kelleher, N. L. (2006). Precise Characterization of Human Histones in the H2A Gene Family by Top Down Mass Spectrometry. Journal of Proteome Research. https://doi.org/10.1021/pr050269n
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