The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Rapid Reaction of Hydrogen Sulfide with the Neutrophil Oxidant Hypochlorous Acid to Generate Polysulfides
Abstract
H₂S has been recognized as a signaling molecule and mediator of inflammation. Here, we report the kinetics and mechanism of its reaction with the neutrophil oxidant hypochlorous acid. Stopped flow studies, carried out at high pH, showed this reaction to be extremely fast, with a second-order rate constant extrapolated to be 2 × 10⁹ M⁻¹ s⁻¹ at pH 7.4. The reaction produces polysulfides rather than polythionates and may represent a novel pathway for protein Cys-sulfhydration, a recently proposed mechanism for H₂S signaling.
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Citations
Cites
H 2 S as a Physiologic Vasorelaxant: Hypertension in Mice with Deletion of Cystathionine γ-Lyase
Yang, G., Wu, L., Jiang, B., Yang, W., Qi, J., Cao, K., Meng, Q., Mustafa, A. K., Mu, W., Zhang, S., et al. (2008) · Science · doi:10.1126/science.1162667 · Cited by 2,310
Cited by
Chemical Biology of H2S Signaling through Persulfidation
Filipovic, M. R., Zivanovic, J., Alvarez, B., & Banerjee, R. (2018) · Chemical Reviews · doi:10.1021/acs.chemrev.7b00205 · Cited by 1,046
Physiological roles of hydrogen sulfide in mammalian cells, tissues, and organs
Cirino, G., Szabo, C., & Papapetropoulos, A. (2023) · Physiological Reviews · doi:10.1152/physrev.00028.2021 · Cited by 553
Enzymology of H 2 S Biogenesis, Decay and Signaling
Kabil, O., & Banerjee, R. (2014) · Antioxidants & Redox Signaling · doi:10.1089/ars.2013.5339 · Cited by 473
Ono, K., Akaike, T., Sawa, T., Kumagai, Y., Wink, D. A., Tantillo, D. J., Hobbs, A. J., Nagy, P., Xian, M., Lin, J., et al. (2014) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2014.09.007 · Cited by 422
Self-citationSignaling Molecules: Hydrogen Sulfide and Polysulfide
Kimura, H. (2015) · Antioxidants & Redox Signaling · doi:10.1089/ars.2014.5869 · Cited by 351
Metadata
- Authors
- Nagy, P., & Winterbourn, C. C.
- Venue
- Chemical Research in Toxicology
- Publisher
- American Chemical Society (ACS)
- Published
- 2010-09-16
- Volume
- 23
- Issue
- 10
- Pages
- 1541-1543
- ISSN
- 0893-228X (ISSN-L)
- 1520-5010
- OpenAlex
- W1975509532
- Cited by
- 212
- References
- 1
- FWCI
- 2.43
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
