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Power of Selective Genotyping in Genetic Association Analyses of Quantitative Traits
Abstract
A power calculation is described in which the power of selective genotyping in genetic association studies of quantitative traits is evaluated. The method of selective genotyping implies the selection of the extremely high and low scoring individuals from the continuous distribution of a quantitative trait. The selected individuals are genotyped and association is tested. In the power calculation the following parameters are varied: total sample size of the phenotyped group (1000, 1500, 2000); selection of extremely high and low scoring individuals (2.5%, 5%, 10%); allele frequency of the risk increasing allele (0.10 to 0.90); mode of inheritance and proportion of variance explained by the quantitative trait locus (QTL) (omega 2 = 0.01, 0.05, 0.10). We conclude that the method of selective genotyping is a powerful method to detect association for a quantitative trait.
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Selective genotyping, in which individuals are sampled from the opposite tails of a quantitative trait, can substantially increase the power of population-based association studies.
“Our alternative approach of selective genotyping, in which individuals are sampled from the opposite tails of a quantitative trait, can substantially increase the power of population-based associations studies (Schork et al., 2000; Van Gestel et al., 2000).”
From Hypnotizability and Catechol-O-Methyltransferase (COMT) polymorphysms in Italians (2014) · cites this paper as Van Gestel et al., 2000
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Metadata
- Authors
- Van Gestel, S., Houwing-Duistermaat, J. J., Adolfsson, R., van Duijn, C. M., & Van Broeckhoven, C.
- Affiliations
- Umeå University (SE)
- Erasmus University Rotterdam (NL)
- Corresponding author
- Adolfsson, Rolf
- Venue
- Behavior Genetics
- Published
- 2000-03
- Volume
- 30
- Issue
- 2
- Pages
- 141-146
- ISSN
- 0001-8244 (ISSN-L)
- 1573-3297
- OpenAlex
- W1531142817
- Cited by
- 108
- References
- 0
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 13 · 2023: 1 · 2022: 1 · 2021: 4 · 2019: 4 · 2018: 3 · 2017: 4 · 2016: 2 · 2015: 4 · 2014: 7 · 2013: 3 · 2012: 5
- FWCI
- 1.75
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Behavior Genetics (publishedVersion)
- PubMed (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
- Funders
- Fonds Wetenschappelijk Onderzoek
- Vlaamse regering
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Mapping and Diversity in Plants and Animals
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and phenotypic traits in livestock
- Keywords
- selective genotyping, genetic association studies, quantitative traits, statistical power, sample size, allele frequency, mode of inheritance, quantitative trait loci, heritability
- MeSH terms
- Chromosome Mapping, Genotype, Humans, Models, Genetic, Phenotype, Selection, Genetic, Quantitative Trait, Heritable
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