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Application of a Biomagnetic Measurement System (BMS) to the Evaluation of Gastrointestinal Transit of Intestinal Pressure-Controlled Colon Delivery Capsules (PCDCs) in Human Subjects
Abstract
Purpose For determination of the transit time through various parts of the gastrointestinal (GI) tract, we developed a method that provides the location of disintegration and drug release. This method involves GI magnetomarkergraphy (GIMG) using a 129-channel Shimadzu vector biomagnetic measurement system (BMS). Methods To magnetically label the pressure-controlled colon delivery capsule (PCDC) containing 75.0 +/- 0.5 mg of caffeine as a tracer drug, small capsule caps containing 90 mg of ferric oxide powdered magnetite (Fe2O3) were attached to PCDCs. After orally administration to fasted human volunteers, saliva samples were collected hourly and salivary caffeine concentration was measured. At the same time, locations of the magnetic PCDC were detected by BMS just after the PCDCs were magnetized with the coils of a magnetic resonance imaging (MRI) system. The magnetic field distributions were analyzed and the estimated positions were shown on the MRI picture of the same subject's abdominal structure. Results We magnetized PCDC with permanent magnets or an electromagnet before ingestion and the estimated locations of PCDC in the GI tract exhibited high estimation error. In order to increase the precision of estimated localization of PCDCs, PCDCs were magnetized within the coils of the MRI. As a result, these PCDCs had strong magnetic dipoles that were parallel to the sensor unit of BMS in every measurement, and therefore the spatial resolution of the PCDC's two-dimensional po…
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“while small intestine transit time is considered constant at approximately 4 h.90”
From Current Advances in Chitosan Nanoparticles Based Oral Drug Delivery for Colorectal Cancer Treatment (2022) · cites this paper as [90]
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Hua, S. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.00524 · Cited by 527
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Metadata
- Authors
- Hu, Z., Mawatari, S., Shibata, N., Takada, K., Yoshikawa, H., Arakawa, A., & Yosida, Y.
- Affiliations
- Kyoto Pharmaceutical University (JP)
- University of Toyama (JP)
- Shimadzu (Japan) (JP)
- Corresponding author
- Takada, Kanji
- Venue
- Pharmaceutical Research
- Published
- 2000-02
- Volume
- 17
- Issue
- 2
- Pages
- 160-167
- ISSN
- 0724-8741 (ISSN-L)
- 1573-904X
- OpenAlex
- W345357030
- Semantic Scholar
- 594ae4ed360cab28e4a8a0cb2e61bf57a29aa9dd
- Cited by
- 46
- References
- 20
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 3 · 2022: 3 · 2021: 2 · 2020: 3 · 2019: 2 · 2018: 2 · 2017: 1 · 2015: 2 · 2014: 1 · 2013: 2 · 2012: 1
- FWCI
- 2.90
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springernature.com/gp/researchers/text-and-data-mining (tdm)
- www.springernature.com/gp/researchers/text-and-data-mining (vor)
- Locations
- Pharmaceutical Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Physical Sciences › Engineering › Electrical and Electronic Engineering › Magnetic Field Sensors Techniques
- Keywords
- gastrointestinal transit, colon-targeted drug delivery, capsule localization, magnetic field distribution, human volunteers
- MeSH terms
- Abdomen, Administration, Oral, Central Nervous System Stimulants, Caffeine, Capsules, Colon, Humans, Intestinal Absorption, Magnetic Resonance Imaging, Pressure, Saliva, Suppositories, Reproducibility of Results, Drug Delivery Systems
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- The paper
- Hu, Z., Mawatari, S., Shibata, N., Takada, K., Yoshikawa, H., Arakawa, A., & Yosida, Y. (2000). Application of a Biomagnetic Measurement System (BMS) to the Evaluation of Gastrointestinal Transit of Intestinal Pressure-Controlled Colon Delivery Capsules (PCDCs) in Human Subjects. Pharmaceutical Research. https://doi.org/10.1023/a%3A1007561129221
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