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Cited by 15HIV Research and TreatmentT-cell and Retrovirus StudiesGenomics and Chromatin Dynamics

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Deletion Analysis of Both the Long Terminal Repeat and the Internal Promoters of the Human Foamy Virus

Yang, Ping, Zemba, Motomi, Aboud, Mordechai, Flügel, Rolf M., Löchelt, Martin·1997·Virus Genes
DOI 10.1023/a:1007994527345
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Abstract

Deletion analyses of the long terminal repeat (LTR) and internal promoters (IP) of human foamy virus (HFV) showed that a negative acting element resides in the U5 region of the 5' LTR reducing reporter gene expression tenfold. The basal activity of the IP was higher than that obtained with LTR promoter constructs and strongly elevated in permissive BHK-21 cells whereas semi-permissive COS-7 cells showed low basal activity. Since the basal activity of the IP is critical for initiating HFV gene expression by providing Bel 1 transactivator early after infection, the basal activity of the IP may be the crucial factor that contributes to whether cells are permissive for HFV infection or not. Deletion mutagenesis allowed to define the minimal IP region. A region strongly transactivated by Bel 1 extends from -136 to +58 relative to the cap site of the IP. The major Bel 1 response element of the IP required for transactivation is located upstream of the cap site between -136 and -88 relative to the internal cap site. A DNA fragment reported to be protected by recombinant Bel 1 was deleted with marginal reduction of Bel 1 transactivation. HFV gene expression directed by the IP and LTR promoters is thus multiply regulated by positive and negative acting response elements in cis and their binding partners in trans.

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Crossref · 10.1023/a:1007994527345

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  • In spumaviruses, transcription from the LTR promoter depends on Tas expressed from the IP; use of the IP allows enough Tas to accumulate, facilitating efficient binding to the LTR promoter rather than to the IP, enabling efficient transcription of viral transcripts that express structural and enzymatic proteins.

    “In spumaviruses, since transcription from the LTR promoter depends on Tas (trans-activator of spumavirus), which is expressed from the IP, use of the IP allows enough Tas to accumulate, facilitating its efficient binding to the LTR promoter rather than to the IP. This enables efficient transcription of viral transcripts that express structural and enzymatic proteins (Yang et al. 1997, Kang et al.”

    From Beyond reverse transcription: molecular mechanisms and emerging paradigms in retroviral replication (2026) · cites this paper as Yang et al. 1997

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Metadata

Authors
Yang, P., Zemba, M., Aboud, M., Flügel, R. M., & Löchelt, M.
Affiliations
  • German Cancer Research Center (DE)
  • Ben-Gurion University of the Negev (IL)
ORCID
Yang, Ping
Venue
Virus Genes
Publisher
Springer Science and Business Media LLC
Published
1997-07
Volume
15
Issue
1
Pages
17-23
ISSN
  • 0920-8569 (ISSN-L)
  • 1572-994X
DOI
10.1023/a:1007994527345
OpenAlex
W2260381594
Cited by
15
References
0
Citations by year
2025: 1 · 2018: 1 · 2013: 1 · 2012: 2
FWCI
0.40
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Virus Genes (publishedVersion)
  • PubMed (publishedVersion)
Funders
Deutscher Akademischer Austauschdienst
Topics
  • Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and Retrovirus Studies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Keywords
human foamy virus, long terminal repeat, internal promoter, U5 region, permissive cells, viral gene expression regulation
MeSH terms
Animals, Cells, Cultured, Cricetinae, Humans, Promoter Regions, Genetic, Regulatory Sequences, Nucleic Acid, Repetitive Sequences, Nucleic Acid, Viral Proteins, Spumavirus, Genome, Viral, Gene Deletion, COS Cells

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