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CASE REPORT: Combination Therapy with Bifidobacterium breve, Lactobacillus casei, and Galactooligosaccharides Dramatically Improved the Intestinal Function in a Girl with Short Bowel Syndrome: A Novel Synbiotics Therapy for Intestinal Failure
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In a child with 25 cm of residual small intestine and severe dysbiosis, a synbiotic combination rapidly restored healthier anaerobic flora, reduced pathogenic overgrowth, resolved infections, metabolic instability, and feeding intolerance, and enabled transition off parenteral nutrition.
“In one case, a child with only 25 cm of residual small intestine and severe dysbiosis, a synbiotic combination (Bifidobacterium breve, Lactobacillus casei, galacto-oligosaccharides) rapidly restored a healthier anaerobic flora, reduced pathogenic overgrowth, and led to resolution of infections, metabolic instability, and feeding intolerance, ultimately enabling transition off parenteral nutrition”
From Pre-, Pro-, Post- and Synbiotics in Pediatric Short Bowel Syndrome: A Narrative Review of Current Evidence (2026) · cites this paper as [25]
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KISA BAĞIRSAK SENDROMUNDA TIBBİ BESLENME TEDAVİSİ VE BAĞIRSAK ADAPTASYONUNDA BESİN MÜDAHALELERİ
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Höllwarth, M. E. (2020) · Springer eBooks · doi:10.1007/978-3-662-43588-5_80 · Cited by 1
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Letter to the editor: “What every intensivist should know about type D hyperlactatemia”
Moury, J., Gennart, T., Blackman, S., Lissnyder, N. D., Errais, O., & Honoré, P. M. (2025) · Journal of Critical Care · doi:10.1016/j.jcrc.2025.155138 · Cited by 1
Reduced sepsis with enteral antibiotics in children with intestinal failure
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Probiotics and the Immunocompromised Host
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“For example, Kanamori et al. [ 33 ] reported a 4-yearold with parenteral nutrition-dependent short bowel syndrome secondary to gastroschisis who was treated with a mixture of Bifidobacterium breve , L. casei , and galactose oligosaccharides.”
BackgroundKaufman, S. S. (2010) · Elsevier eBooks · doi:10.1016/b978-1-4377-0774-8.10036-3
Venick, R. S. (2021) · Elsevier eBooks · doi:10.1016/b978-0-323-67293-1.00035-9
Höllwarth, M. E. (2017) · Springer eBooks · doi:10.1007/978-3-642-38482-0_80-1
Höllwarth, M. E. (2019) · Springer eBooks · doi:10.1007/978-3-642-38482-0_80-2
Vanderhoof, J. A., & Young, R. J. (2004) · CRC Press eBooks · doi:10.1201/9780203504581.ch12
Andhary, V. S., Razan, R. A., & Partiwi, I. G. A. N. (2025) · Jurnal Gastrohepatologi Anak Indonesia/Archives of Pediatric Gastroenterology, Hepatology, and Nutrition · doi:10.58427/apghn.4.1.2025.23-30
Venick, R. S. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-11760-2.00035-5
The effect of a prebiotic with a probiotic on symptoms and quality of life in ulcerative colitis
Haskey, N. (2007) · University Library - University of Saskatchewan (University of Saskatchewan)
Morotti, F., Fiore, G., Mari, A., Bona, F., Dolor, J., Giorgio, V., Nibali, R. C., Coletta, R., Lacitignola, L., Leon, F. F., et al. (2026) · European Journal of Pediatrics · doi:10.1007/s00431-026-07376-6
Metadata
- Authors
- Kanamori, Y., Hashizume, K., Sugiyama, M., Morotomi, M., & Yuki, N.
- Affiliations
- The University of Tokyo (JP)
- Yakult Central Institute (JP)
- Venue
- Digestive Diseases and Sciences
- Published
- 2001-09
- Volume
- 46
- Issue
- 9
- Pages
- 2010-2016
- ISSN
- 0163-2116 (ISSN-L)
- 1573-2568
- OpenAlex
- W2143349234
- Cited by
- 85
- References
- 30
- Citations by year
- 2026: 1 · 2025: 3 · 2023: 2 · 2022: 1 · 2021: 5 · 2020: 2 · 2019: 4 · 2018: 1 · 2017: 2 · 2016: 3 · 2015: 1 · 2014: 3 · 2013: 4 · 2012: 4
- FWCI
- 8.50
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Digestive Diseases and Sciences (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Health Sciences › Nursing › Nutrition and Dietetics › Clinical Nutrition and Gastroenterology
- Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
- Keywords
- short bowel syndrome, synbiotics, Bifidobacterium breve, Lactobacillus casei, galactooligosaccharides, intestinal failure, intestinal function, probiotics, prebiotics, pediatric patients
- MeSH terms
- Bifidobacterium, Body Weight, Child, Preschool, Cholinesterases, Drug Therapy, Combination, Feces, Female, Gastrointestinal Motility, Humans, Intestinal Absorption, Lacticaseibacillus casei, Oligosaccharides, Radiography, Short Bowel Syndrome, Probiotics
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