Structural and catalytic chemistry of magnesium-dependent enzymes

Cowan, J.A.

doi:10.1023/a:1016022730880

Cited by 436Enzyme Structure and FunctionMetalloenzymes and iron-sulfur proteinsMetal-Catalyzed Oxygenation Mechanisms

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Structural and catalytic chemistry of magnesium-dependent enzymes

Cowan, J.A.·2002·Biometals

DOI 10.1023/a:1016022730880

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Ribosomes and other negatively charged macromolecules and metabolites buffer free Mg2+ near 1 mM, with a range of ~0.3 to 3 mM.
“Collectively, ribosomes and other negatively charged macromolecules and metabolites buffer free Mg2+ near 1 mM, with a range of ∼0.3 to 3 mM.5,8,71,72”
From Metals in Motion: Understanding Labile Metal Pools in Bacteria (2025) · cites this paper as [71]
A subset of Mg2+-dependent enzymes form relatively stable associations with Mg2+ (Kd of 10-100 μM).
“Although many Mg2+-dependent enzymes bind to ATP:Mg2+ (or other substrate:Mg2+ complexes), a subset form relatively stable associations with Mg2+ (Kd of 10–100 μM),71 and it is possible that some of this Mg2+ may be functionally sequestered.”
From Metals in Motion: Understanding Labile Metal Pools in Bacteria (2025) · cites this paper as [71]

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Authors: Cowan, J. A.
Affiliations: The Ohio State University (US)
Corresponding author: Cowan, J.A.
ORCID: Cowan, J.A.
Venue: Biometals
Publisher: Springer Science and Business Media LLC
Published: 2002-09
Volume: 15
Issue: 3
Pages: 225-235
ISSN: 0966-0844 (ISSN-L)
1572-8773
DOI: 10.1023/a:1016022730880
OpenAlex: W1537110470
Cited by: 428
References: 33
Citations by year: 2026: 25 · 2025: 34 · 2024: 23 · 2023: 24 · 2022: 25 · 2021: 22 · 2020: 28 · 2019: 17 · 2018: 36 · 2017: 20 · 2016: 14 · 2015: 25 · 2014: 26 · 2013: 16 · 2012: 25
FWCI: 0.27
Type: journal article
Language: en
Open access: closed
Licence: www.springernature.com/gp/researchers/text-and-data-mining (tdm)
www.springernature.com/gp/researchers/text-and-data-mining (vor)
Locations: BioMetals (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Structural Biology › Enzyme Structure and Function
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Metalloenzymes and iron-sulfur proteins
Physical Sciences › Chemistry › Inorganic Chemistry › Metal-Catalyzed Oxygenation Mechanisms
Keywords: magnesium-dependent enzyme, enzyme structure, enzyme catalysis, metalloenzymes, magnesium ions, enzyme active site
MeSH terms: Catalysis, Enzymes, Magnesium, Nucleic Acids, Phosphorylation, Molecular Structure

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