The DOI matches its Crossref record; 39 of the 40 references it cites were found in a registry or an index.
Alterations in antioxidant enzymes and oxidative damage in experimental diabetic rat tissues: Effect of vanadate and fenugreek (Trigonella foenum graecum)
Abstract
With the premise that oxygen free radicals may be responsible for the severity and complications of diabetes, the level of antioxidant enzymes catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GPx) as well as the oxidative damage were examined in the tissues of control, diabetic and treated rats. After 3 weeks of diabetes, the activity of CAT was significantly increased in heart in diabetes (about 6-fold) but decreased in liver. The SOD activity decreased significantly in liver but increased in brain. The activity of GPx decreased significantly in liver and increased in kidney. A significant increase was observed in oxidative damage in heart and kidney and a small increase in brain with decrease in liver and muscle. Vanadate and fenugreek (Trigonella foenum graecum) administration to diabetic animals showed a reversal of the disturbed antioxidant levels and peroxidative damage. Results suggest that oxidative stress play a key role in the complications of diabetes. Vanadate and fenugreek seeds showed an encouraging antioxidant property and can be valuable candidates in the treatment of the reversal of the complications of diabetes.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“The study with Shihao et al. on traumatic brain injury (TBI) in rats reported that peritoneal injection of Ecdy (16 mg/kg) for seven days resulted in signi cant decreases in the neuronal death rate, brain water content, MDA content, and a noticeable increase in SOD enzymes in the hippocampus compared with TBI group”
Citations
Cites
PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT
Lowry, O., Rosebrough, N., Farr, A. L., & Randall, R. (1951) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)52451-6 · Cited by 317,331
Marklund, S. L., & MARKLUND, G. (1974) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1974.tb03714.x · Cited by 10,382
Role of Oxidative Stress in Development of Complications in Diabetes
Baynes, J. (1991) · Diabetes · doi:10.2337/diab.40.4.405 · Cited by 3,826
Glutathione peroxidase activity in selenium-deficient rat liver
Lawrence, R. A., & Burk, R. F. (1976) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(76)90747-6 · Cited by 3,536
Aebi, H. E. (1974) · Elsevier eBooks · doi:10.1016/b978-0-12-091302-2.50032-3 · Cited by 2,136
The measurement and mechanism of lipid peroxidation in biological systems
Gutteridge, J. M. C., & Halliwell, B. B. (1990) · Trends in Biochemical Sciences · doi:10.1016/0968-0004(90)90206-q · Cited by 1,297
Oberley, L. W. (1988) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(88)90036-6 · Cited by 1,105
Effect of Vanadate on Elevated Blood Glucose and Depressed Cardiac Performance of Diabetic Rats
Heyliger, C. E., Tahiliani, A. G., & McNeill, J. H. (1985) · Science · doi:10.1126/science.3156405 · Cited by 711
Wohaieb, S. A., & Godin, D. V. (1987) · Diabetes · doi:10.2337/diab.36.9.1014 · Cited by 686
Insulin-like stimulation of glucose oxidation in rat adipocytes by vanadyl (IV) ions
Shechter, Y., & KARLISH, S. J. D. (1980) · Nature · doi:10.1038/284556a0 · Cited by 555
Research works printed but not linked: 2
- Genet S, Kale RK, Baquer NZ: Effect of vanadate, insulin and fenugreek (Trigonella foenum graecum) on creatine kinase level in tissue of diabetic rats. Ind J Exp Biol 37: 200–202, 1999
- Moorthy R, Prabu KM, Murthy PS: Studies on the isolation and effect of orally active hypoglycemic principle from the seeds of fenugreek (Trigonella Foenum Graecum). Diabetes Bull 9: 69–72, 1989
Cited by
Crans, D. C., Smee, J. J., Gaidamauskas, E., & Yang, L. (2004) · Chemical Reviews · doi:10.1021/cr020607t · Cited by 1,364
Leads from Indian medicinal plants with hypoglycemic potentials
Mukherjee, P. K., Maiti, K., Mukherjee, K., & Houghton, P. J. (2006) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2006.03.021 · Cited by 524
Fenugreek (Trigonella foenum-graecum): A Review of Health Beneficial Physiological Effects
Srinivasan, K. (2006) · Food Reviews International · doi:10.1080/87559120600586315 · Cited by 377
Antioxidant Potential of Spices and Their Active Constituents
Srinivasan, K. (2012) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2011.585525 · Cited by 314
Catalase Protects Cardiomyocyte Function in Models of Type 1 and Type 2 Diabetes
Ye, G., Metreveli, N. S., Donthi, R. V., Shen, X., Xu, M., Carlson, E. C., & Epstein, P. N. (2004) · Diabetes · doi:10.2337/diabetes.53.5.1336 · Cited by 278
Metadata
- Authors
- Genet, S., Kale, R. K., & Baquer, N. Z.
- Affiliations
- Jawaharlal Nehru University (IN)
- Corresponding author
- Baquer, Najma Z.
- ORCID
- Genet, Solomon
- Venue
- Molecular and Cellular Biochemistry
- Published
- 2002-07
- Volume
- 236
- Issue
- 1-2
- Pages
- 7-12
- ISSN
- 0300-8177 (ISSN-L)
- 1573-4919
- OpenAlex
- W255295199
- Cited by
- 258
- References
- 40
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 4 · 2023: 10 · 2022: 6 · 2021: 12 · 2020: 6 · 2019: 10 · 2018: 11 · 2017: 16 · 2016: 15 · 2015: 13 · 2014: 18 · 2013: 25 · 2012: 16
- FWCI
- 3.80
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springernature.com/gp/researchers/text-and-data-mining (tdm)
- www.springernature.com/gp/researchers/text-and-data-mining (vor)
- Locations
- Molecular and Cellular Biochemistry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
- Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
- Physical Sciences › Chemistry › Inorganic Chemistry › Vanadium and Halogenation Chemistry
- Keywords
- diabetes mellitus, oxidative stress, antioxidant enzymes, catalase, superoxide dismutase, glutathione peroxidase, lipid peroxidation, vanadate, fenugreek, diabetes complications, tissue distribution of enzymes, heart, liver, kidney, brain
- MeSH terms
- Alloxan, Animals, Antioxidants, Body Weight, Brain, Catalase, Diabetes Mellitus, Experimental, Female, Glutathione Peroxidase, Insulin, Kidney, Liver, Organ Size, Plant Extracts, Superoxide Dismutase, Time Factors, Vanadates, Lipid Peroxidation, Rats, Wistar, Oxidative Stress, Trigonella, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Alterations in antioxidant enzymes and oxidative damage in experimental diabetic rat tissues: Effect of vanadate and fenugreek (Trigonella foenum graecum). https://app.cochat.ai/papers/10.1023/a:1016103131408
- The paper
- Genet, S., Kale, R. K., & Baquer, N. Z. (2002). Alterations in antioxidant enzymes and oxidative damage in experimental diabetic rat tissues: Effect of vanadate and fenugreek (Trigonella foenum graecum). Molecular and Cellular Biochemistry. https://doi.org/10.1023/a%3A1016103131408
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
