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Cited by 57Helicobacter pylori-related gastroenterology studiesNeuroendocrine Tumor Research AdvancesGastric Cancer Management and Outcomes

The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.

Gastric Carcinoid Tumors Without Autoimmune Gastritis in Japan: A Relationship with Helicobacter pylori Infection

Sato, Yuichi, Iwafuchi, Mitsuya, Ueki, Jun-ichi, Yoshimura, Akira, Mochizuki, Tsutomu, Motoyama, Hirotaka, Sugimura, Kazuhito, Honma, Terasu, Narisawa, Rintaro, Ichida, Takafumi, Asakura, Hitoshi, Van Thiel, David H.·2002·Digestive Diseases and Sciences
DOI 10.1023/a:1017972204219
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Abstract

In Japan, most cases of gastric carcinoid tumor (GCT) are unassociated with either autoimmune gastritis (AIG) showing type-A chronic atrophic gastritis (CAG-A) or Zollinger-Ellison syndrome (ZES). However, the pathogenesis of this tumor remains unknown. Recent studies have determined that Helicobacter pylori infection induces gastric carcinoid in Mongolian gerbils and that H. pylori lipopolysaccharide exerts a mitogenic effect on ECL cells. We examined five patients with histologically diagnosed GCT, 40 patients with H. pylori-positive gastric ulcer (Hp+GU), 24 patients with H. pylori-positive duodenal ulcer (Hp+DU), and 12 patients with AIG showing CAG-A topographically. We compared the prevalence of H. pylori infection, and the levels of gastrin and pepsinogen (PG) in the serum of patients with GCT with those of patients with Hp+GU, or Hp+DU, and AIG. We also investigated the histological characteristics of the tumor and the gastric corpus mucosa in the GCT patients. The levels of serum gastrin and PG I and II were measured using an RIA kit. In all five (100%) patients with GCT, H. pylori infection was present, without any evidence of AIG or ZES. The serum levels of gastrin in the GCT patients were higher than those in either Hp+GU or Hp+DU patients and lower than those in the AIG patients. In contrast, serum PG I levels and the PG I/II ratio were lower in the GCT group than in the Hp+GU or Hp+DU groups. Histologically, all GCTs were ECL cell tumors and peritumoral corporal mucosal atrophy was observed in four of the five patients with GCT. In conclusions, H. pylori infection and hypergastrinemia were found in the patients with GCT without AIG. This finding suggests that H. pylori infection may induce corporal mucosal atrophy and hypergastrinemia that can produce a GCT with time.

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Crossref · 10.1023/a:1017972204219

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Research works printed but not linked: 1

  1. Chittajulla RS, Ardill JES, McColl KEL: The degree of hypergastrinemia induced by Helicobacter pylori is the same in duodenal ulcer patients and asymptomatic volunteers. Eur J Gastroenterol 4:49–53, 1992

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Metadata

Authors
Sato, Y., Iwafuchi, M., Ueki, J.-I., Yoshimura, A., Mochizuki, T., Motoyama, H., Sugimura, K., Honma, T., Narisawa, R., Ichida, T., Asakura, H., & Van Thiel, D. H.
Affiliations
  • Niigata University (JP)
  • Niigata Prefectural Central Hospital (JP)
ORCID
Venue
Digestive Diseases and Sciences
Publisher
Springer Science and Business Media LLC
Published
2002-03
Volume
47
Issue
3
Pages
579-585
ISSN
  • 0163-2116 (ISSN-L)
  • 1573-2568
DOI
10.1023/a:1017972204219
OpenAlex
W1562732190
Cited by
57
References
47
Citations by year
2026: 1 · 2025: 2 · 2024: 3 · 2023: 4 · 2021: 5 · 2020: 5 · 2019: 4 · 2018: 2 · 2017: 1 · 2016: 2 · 2015: 2 · 2014: 2 · 2013: 2 · 2012: 3
FWCI
2.54
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Digestive Diseases and Sciences (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Gastroenterology › Helicobacter pylori-related gastroenterology studies
  • Health Sciences › Medicine › Oncology › Neuroendocrine Tumor Research Advances
  • Health Sciences › Medicine › Oncology › Gastric Cancer Management and Outcomes
Keywords
gastric carcinoid, Helicobacter pylori infection, autoimmune gastritis, hypergastrinemia, pepsinogen, atrophic gastritis, Zollinger-Ellison syndrome, gastric ulcer, duodenal ulcer, carcinogenesis
MeSH terms
Adult, Aged, Aged, 80 and over, Autoimmune Diseases, Carcinoid Tumor, Duodenal Ulcer, Female, Gastrins, Gastritis, Gastritis, Atrophic, Humans, Male, Middle Aged, Peptic Ulcer, Stomach Neoplasms, Helicobacter pylori, Helicobacter Infections, Pepsinogen C, Pepsinogen A

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