The DOI matches its Crossref record; 39 of the 40 references it cites were found in a registry or an index.
Modulation of the phenotypic and functional properties of phagocytic macrophages by wear particles from orthopaedic implants
Abstract
An attempt was made to assess the local chronic inflammatory response in patients with failed orthopaedic implant that is clinically associated with osteolysis, bone and bone marrow necrosis. The main objective was to analyse the heterogeneity of the macrophage functional subsets in the bone-implant interface membrane and to evaluate their possible role in the development of an erosive inflammatory lesion within the bone. Immunohistology was performed on 21 specimens of the bone-implant interface obtained from 17 patients during revision arthroplasty, and synovial membranes from rheumatoid (RA, n=4), and osteoarthritis (OA, n=4) patients. Three well-characterized monoclonal antibodies (MAb) recognizing antigenic determinants on specific functional subsets of macrophages (Mphi) were used. RFD1 (interdigitating reticulum cells/antigen presenting cells, (APC), RFD7 (mature phagocytic macrophages), and RFD9 epithelioid cells and foreign body giant cells (FBGC). RFD1 was expressed on a variable number of perivascular and synovial lining Mphi in both RA and OA synovia, at a frequency of 25%-40%. In cases with total joint replacements, the interface showed a marked increase in the expression of RFD1 (20%-90%). A considerably greater percentage of RFD1 positive Mphi and FBGC was noted in the interfaces from cases with a high level of detectable metal particulate wear debris (mean 80%, range 60%-90%) than in cases with polyethylene wear debris (mean 30%, range 0%-50%), p 0.0001. RFD7…
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“Foreign body giant cells in tissue removed from human implant surgeries have been shown in situ to express macrophage-associated membrane molecules such as CD45 (leukocyte common antigen), CD13, CD14, CD15A (Hapten X), CD37, CD39, CD43, and HLA-DR; receptors such as CD16 (FcRIII), CD31 (FcRII), CD35 (C3b receptor), CD71 (transferrin receptor); and adhesion molecules such as CD11a,b,c, CD18 (leukoc”
From Foreign body reaction to biomaterials (2008) · cites this paper as [76]
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Cited by
Foreign body reaction to biomaterials
Anderson, J. M., Rodriguez, A., & Chang, D. T. (2008) · Seminars in Immunology · doi:10.1016/j.smim.2007.11.004 · Cited by 5,138
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Self-citationLocalized Immunosuppressive Environment in the Foreign Body Response to Implanted Biomaterials
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Metadata
- Authors
- AL-SAFFAR, N., REVELL, P. A., & KOBAYASHI, A.
- Affiliations
- The Royal Free Hospital (GB)
- ORCID
- KOBAYASHI, A
- Venue
- Journal of Materials Science: Materials in Medicine
- Published
- 1997-11
- Volume
- 8
- Issue
- 11
- Pages
- 641-648
- ISSN
- 0957-4530 (ISSN-L)
- 1573-4838
- OpenAlex
- W348347653
- Cited by
- 38
- References
- 40
- Citations by year
- 2025: 1 · 2021: 2 · 2020: 1 · 2017: 1 · 2016: 1 · 2014: 1 · 2012: 1
- FWCI
- 1.50
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springernature.com/gp/researchers/text-and-data-mining (tdm)
- www.springernature.com/gp/researchers/text-and-data-mining (vor)
- Locations
- Journal of Materials Science Materials in Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Orthopaedic implants and arthroplasty
- Health Sciences › Medicine › Surgery › Orthopedic Infections and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Keywords
- macrophage heterogeneity, metal wear debris, bone-implant interface, chronic inflammation, osteolysis, foreign body giant cells, antigen-presenting macrophages, synovial macrophages, rheumatoid arthritis, osteoarthritis, total joint arthroplasty, revision arthroplasty, polyethylene wear debris
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- AL-SAFFAR, N., REVELL, P. A., & KOBAYASHI, A. (1997). Modulation of the phenotypic and functional properties of phagocytic macrophages by wear particles from orthopaedic implants. Journal of Materials Science: Materials in Medicine. https://doi.org/10.1023/a%3A1018575504518
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
