Forskolin as a Tool for Examining Adenylyl Cyclase Expression, Regulation, and G Protein Signaling

Forskolin: unique diterpene activator of adenylate cyclase in membranes and in intact cells.

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Crystal Structure of the Catalytic Domains of Adenylyl Cyclase in a Complex with G sα ·GTPγS

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Differential Targeting of β-Adrenergic Receptor Subtypes and Adenylyl Cyclase to Cardiomyocyte Caveolae

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Structure of the adenylyl cyclase catalytic core

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Compartmentation of G Protein-Coupled Signaling Pathways in Cardiac Myocytes

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Direct Demonstration of Mechanically Induced Release of Cellular UTP and Its Implication for Uridine Nucleotide Receptor Activation

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Stimulation of forskolin of intact S49 lymphoma cells involves the nucleotide regulatory protein of adenylate cyclase.

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RGS-PX1, a GAP for Gα s and Sorting Nexin in Vesicular Trafficking

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Inhibition of cyclin-dependent kinases 2 and 4 activities as well as induction of cdk inhibitors p21 and p27 during growth arrest of human breast carcinoma cells by (?)-epigallocatechin-3-gallate

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Reconstitution of catecholamine-stimulated adenylate cyclase activity using three purified proteins.

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Activation of Cyclic AMP‐Generating Systems in Brain Membranes and Slices by the Diterpene Forskolin: Augmentation of Receptor‐Mediated Responses

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Forskolin, adenylate cyclase, and cell physiology: an overview.

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Cellular Release of and Response to ATP as Key Determinants of the Set-Point of Signal Transduction Pathways

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Stoichiometry and Compartmentation in G Protein-Coupled Receptor Signaling: Implications for Therapeutic Interventions Involving Gs

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Identification of a Giα Binding Site on Type V Adenylyl Cyclase

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Quantitation of extracellular UTP using a sensitive enzymatic assay

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Localization of Adenylyl Cyclase Isoforms and G Protein-Coupled Receptors in Vascular Smooth Muscle Cells: Expression in Caveolin-Rich and Noncaveolin Domains

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Regulation of forskolin interactions with type I, II, V, and VI adenylyl cyclases by Gs.alpha.

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Structure-activity relationships for activation of adenylate cyclase by the diterpene forskolin and its derivatives

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Stoichiometry of receptor‐G s ‐adenylate cyclase interactions

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Selective enhancement of beta-adrenergic receptor signaling by overexpression of adenylyl cyclase type 6: colocalization of receptor and adenylyl cyclase in caveolae of cardiac myocytes.

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Regulation of the Ca2+-inhibitable Adenylyl Cyclase Type VI by Capacitative Ca2+ Entry Requires Localization in Cholesterol-rich Domains

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Increased expression of adenylylcyclase type VI proportionately increases β-adrenergic receptor-stimulated production of cAMP in neonatal rat cardiac myocytes

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Quantification of signalling components and amplification in the β-adrenergic-receptor-adenylate cyclase pathway in isolated adult rat ventricular myocytes

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Reconstitution of a hormone-sensitive adenylate cyclase system. The pure beta-adrenergic receptor and guanine nucleotide regulatory protein confer hormone responsiveness on the resolved catalytic unit.

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Binding of [3H]forskolin to rat brain membranes.

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Interactions of Forskolin and ATP with the Cytosolic Domains of Mammalian Adenylyl Cyclase

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Properties of the adenylate cyclase catalytic unit from caudate nucleus.

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Interaction of forskolin with the P-glycoprotein multidrug transporter

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Selective Enhancement of β-Adrenergic Receptor Signaling by Overexpression of Adenylyl Cyclase Type 6: Colocalization of Receptor and Adenylyl Cyclase in Caveolae of Cardiac Myocytes

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[3H]forskolin. Direct photoaffinity labeling of the erythrocyte D-glucose transporter.

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Alteration in Gs-mediated signal transduction in S49 lymphoma cells treated with inhibitors of microtubules.

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P2Y11 Receptors Activate Adenylyl Cyclase and Contribute to Nucleotide-promoted cAMP Formation in MDCK-D1Cells

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A Key Role for Protein Kinase A in Homologous Desensitization of the β2-Adrenergic Receptor Pathway in S49 Lymphoma Cells

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The stoichiometry of expression of protein components of the stimulatory adenylyl cyclase cascade and the regulation of information transfer

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Derivatization of the human erythrocyte glucose transporter using a novel forskolin photoaffinity label.

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Agonist regulation of adenylate cyclase activity in neuroblastoma × glioma hybrid NG108-15 cells transfected to co-express adenylate cyclase type II and the β2-adrenoceptor. Evidence that adenylate cyclase is the limiting component for receptor-mediated stimulation of adenylate cyclase activity

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Direct evidence for the role of the coupling proteins in forskolin activation of adenylate cyclase.

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Forskolin photoaffinity labels with specificity for adenylyl cyclase and the glucose transporter

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Molecular mechanism of β‐adrenergic receptor blockers with intrinsic sympathomimetic activity

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Inducible expression of beta 1- and beta 2-adrenergic receptors in rat C6 glioma cells: functional interactions between closely related subtypes.

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Colchicine and cytochalasin B enhance cyclic AMP accumulation via postreceptor actions.

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A direct effect of forskolin on sodium channel bursting

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[5] High-affinity binding sites for [3H]forskolin

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Affinity labeling of forskolin‐binding proteins comparison between glucose carrier and adenylate cyclase

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[125I]-labeled forskolin analogs which discriminate adenylyl cyclase and a glucose transporter: pharmacological characterization and localization of binding sites in rat brain by in vitro receptor autoradiography.

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Differential identification and localization of adenylyl cyclase and glucose transporter in brain using iodinated derivatives of forskolin

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Interaction of aminoalkylcarbamates of forskolin with adenylyl cyclase: synthesis of an iodinated derivative of forskolin with high affinity for adenylyl cyclase.

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Phorbol-Ester Mediated Suppression of hASH1 Synthesis: Multiple Ways to Keep the Level Down

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Switching of G-protein Usage by the Calcium-sensing Receptor Reverses Its Effect on Parathyroid Hormone-related Protein Secretion in Normal Versus Malignant Breast Cells

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Night/Day Changes in Pineal Expression of >600 Genes

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Physiological roles of mammalian transmembrane adenylyl cyclase isoforms

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TLR4-Initiated and cAMP-Mediated Abrogation of Bacterial Invasion of the Bladder

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New Dietary Supplements for Obesity: What We Currently Know

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G Proteins in Cancer: The Prostate Cancer Paradigm

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Activation of Pregnane X Receptor (PXR) and Constitutive Androstane Receptor (CAR) by Herbal Medicines

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Cyclic AMP Signaling in Pancreatic Islets

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Cyclic AMP mediates keratinocyte directional migration in an electric field

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Expression of the neurotrophin receptor trkB is regulated by the cAMP/CREB pathway in neurons

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Ribosomal Protein S6: A Potential Therapeutic Target against Cancer?

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l-DOPA-induced dyskinesia in hemiparkinsonian rats is associated with up-regulation of adenylyl cyclase type V/VI and increased GABA release in the substantia nigra reticulata

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Caveolin-1 and Lipid Microdomains Regulate Gs Trafficking and Attenuate Gs/Adenylyl Cyclase Signaling

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Identification of CCAAT/Enhancer-binding Proteins as Exchange Protein Activated by cAMP-activated Transcription Factors That Mediate the Induction of the SOCS-3 Gene

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Coronin 1 Regulates Cognition and Behavior through Modulation of cAMP/Protein Kinase A Signaling

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INT-767 prevents NASH and promotes visceral fat brown adipogenesis and mitochondrial function

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Mouse sperm K+ currents stimulated by pH and cAMP possibly coded by Slo3 channels

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Hypotensive action of naturally occurring diterpenes: A therapeutic promise for the treatment of hypertension

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The calcium-sensing receptor couples to Gαs and regulates PTHrP and ACTH secretion in pituitary cells

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Morphine Induces CD4+ T Cell IL-4 Expression through an Adenylyl Cyclase Mechanism Independent of the Protein Kinase A Pathway

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Adenylyl cyclases as innovative therapeutic goals

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