Growth limiting substrate affects antibiotic production and associated metabolic fluxes in Streptomyces clavuligerus
Integrity signals
Registry
Cites
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Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Production of clavulanic acid could be improved by refining the composition of the fermentation media.
“Given that both arginine and glyceraldehyde-3-phosphate play an important role in primary metabolism, the production of clavulanic acid could be improved by refining the composition of the fermentation media (Kirk et al., 2000).”
From Fermentation Conditions that Affect Clavulanic Acid Production in Streptomyces clavuligerus: A Systematic Review (2016) · cites this paper as Kirk et al., 2000
Cited by
Sorted by citations
Ser, H.-L., Law, J. W.-F., Chaiyakunapruk, N., Jacob, S. A., Palanisamy, U. D., Chan, K.-G., Goh, B.-H., & Lee, L.-H. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.00522 · Cited by 90 · see citing works
“Given that both arginine and glyceraldehyde-3-phosphate play an important role in primary metabolism, the production of clavulanic acid could be improved by refining the composition of the fermentation media (Kirk et al., 2000).”
Background
- Authors
- Kirk, S., Avignone-Rossa, C. A., & Bushell, M. E.
- Affiliations
- University of Surrey (GB)
- Venue
- Biotechnology Letters
- Published
- 2000-11
- Volume
- 22
- Issue
- 22
- Pages
- 1803-1809
- ISSN
- 0141-5492 (ISSN-L)
- 1573-6776
- OpenAlex
- W265480990
- Cited by
- 50
- References
- 0
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2023: 1 · 2022: 1 · 2021: 3 · 2020: 2 · 2019: 1 · 2018: 2 · 2017: 1 · 2016: 2 · 2015: 2 · 2014: 1 · 2013: 5 · 2012: 1
- FWCI
- 0.66
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Biotechnology Letters (publishedVersion)
- Open Research (University of Surrey) (submittedVersion)
- Surrey Research Insight Open Access (The University of Surrey) (submittedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology › Microbial Natural Products and Biosynthesis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial Metabolic Engineering and Bioproduction
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Keywords
- clavulanic acid biosynthesis, Streptomyces clavuligerus, nutrient limitation, carbon limitation, nitrogen limitation, phosphate limitation, metabolic flux analysis, anaplerotic metabolism, alpha-ketoglutarate, TCA cycle, antibiotic production, chemostat culture
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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