The DOI matches its Crossref record; 44 of the 45 references it cites were found in a registry or an index.
The Effect of Age on the B-Cell Repertoire
Abstract
The antibody repertoire changes with age. This change reflects, in part, the age-associated impairment in the production of a diverse population of naive B cells in the bone marrow and, in part, by the decreased diversification of B cells in the germinal center where affinity maturation and isotype switching takes place. B cell number is strictly regulated and despite the decreased output of B cells by the bone marrow does not decline during aging. Self-renewal of peripheral B cells is sufficient to assure the stability of peripheral B cell number. However, when B cell production is stressed as, for example, following drug-induced lymphopenia, the rate of recovery of B cell number as well as of B cell diversity is compromised in old compared to young mice. Finally, aging is associated with the appearance of B cell clonal expansions which not only limit the diversity of the B cell repertoire but very likely give rise to monoclonal serum immunoglobulins and B cell neoplasms.
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In the citing paper
“Advancing age is accompanied by profound qualitative changes in the peripheral B cell repertoire with reduced clonotypic diversity and a shift towards autoreactive specificities [65 -68].”
From Is there a role for B cells in Alzheimer's disease? (2026) · cites this paper as [68]
In the citing paper
“During ageing, a remodelling of peripheral B cell subsets occurs with a decline in B cell production in the bone marrow and the expansion of atypical B cell subsets, such as age-associated B cells (ABCs) and double-negative (DN) B cells.”
From Is there a role for B cells in Alzheimer's disease? (2026) · cites this paper as [68]
Citations
Cites
Changes in thymic function with age and during the treatment of HIV infection
Douek, D. C., McFarland, R. D., Keiser, P. H., Gage, E. A., Massey, J. M., Haynes, B. F., Polis, M. A., Haase, A. T., Feinberg, M. B., Sullivan#, J. L., et al. (1998) · Nature · doi:10.1038/25374 · Cited by 1,893
The Protective Efficacy of Polyvalent Pneumococcal Polysaccharide Vaccine
Shapiro, E. D., Berg, A. T., AUSTRIAN, R. C., Schroeder, D., Parcells, V., Margolis, A., Adair, R. K., & Clemens, J. D. (1991) · New England Journal of Medicine · doi:10.1056/nejm199111213252101 · Cited by 1,050
The immunology of exceptional individuals: the lesson of centenarians
Franceschi, C., Monti, D., Sansoni, P., & Cossarizza, A. (1995) · Immunology Today · doi:10.1016/0167-5699(95)80064-6 · Cited by 535
Lymphocyte Phytohemagglutinin Responsiveness, Immunoglobulins and Autoantibodies in Aging Humans
Hallgren, H. M., Buckley, C. E., Gilbertsen, V. A., & Yunis, E. J. (1973) · The Journal of Immunology · doi:10.4049/jimmunol.111.4.1101 · Cited by 282
Goidl, E. A., Innes, J. B., & Weksler, M. E. (1976) · The Journal of Experimental Medicine · doi:10.1084/jem.144.4.1037 · Cited by 240
Self-citationImmunosenescence and germinal center reaction
Zheng, B. Q., Han, S., Takahashi, Y., & Kelsoe, G. H. (1997) · Immunological Reviews · doi:10.1111/j.1600-065x.1997.tb01028.x · Cited by 229
Lam, K., & Rajewsky, K. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.190.4.471 · Cited by 223
Impaired Ability of Bone Marrow Stromal Cells to Support B-Lymphopoiesis With Age
Stephan, R. P., Reilly, C. R., & Witte, P. L. (1998) · Blood · doi:10.1182/blood.v91.1.75 · Cited by 197
Natural and Vaccine-Related Immunity to Streptococcus pneumoniae
Musher, D. M., Chapman, A. J., Goree, A., Jónsson, S., Briles, D. E., & BAUGHN, R. E. (1986) · The Journal of Infectious Diseases · doi:10.1093/infdis/154.2.245 · Cited by 197
Effect of age on humoral immunity, selection of the B‐cell repertoire and B‐cell development
LeMaoult, J., Szabo, P., & Weksler, M. E. (1997) · Immunological Reviews · doi:10.1111/j.1600-065x.1997.tb01032.x · Cited by 179
Self-citation
Research works printed but not linked: 4
- Thomsen O, Kettel K: Die starke der menchlichen Isoagglutinine und entsperchenden Blutkorperchenrezeptoren in verchiende Lebensaltern, Z. Immunitatsforsch 63:67, 1929.
- Goidl EA, Stashak PW, Martin-McEvoy SSJ, Hiernaux JR: Age related changes in serum immunoglobulin isotypes and isotype subclass levels among standard long-lived and autoimmune and immunodeficient strains of mice: Serum Ig increases with age. Aging Immunol Infect Dis 1:227, 1989.
- Rowley MJ, Buchanan H, Mackay IR, Mackay IR: Reciprocal change with age in antibody to extrinsic and intrinsic antigens. Lancet 2:24-26, 1968. · DOI
- Lee JW, Jin F, Weksler ME: The nature and significance of age-associated autoimmunity. In The Molecular Pathology of Autoimmune Diseases, 2nd ed AN Theofilopoulos, C Bona (eds) (in press).
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CD153 promotes B-cell responses to immunization in aged mice
Thomas, A. L., Wayman, J. A., Almanan, M., Ferguson, A., Bejjani, A. T., Miraldi, E. R., Chougnet, C. A., & Hildeman, D. A. (2026) · The Journal of Immunology · doi:10.1093/jimmun/vkag188
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Metadata
- Authors
- Weksler, M. E., & Szabo, P.
- Affiliations
- Cornell University (US)
- Venue
- Journal of Clinical Immunology
- Published
- 2000-07
- Volume
- 20
- Issue
- 4
- Pages
- 240-249
- ISSN
- 0271-9142 (ISSN-L)
- 1573-2592
- OpenAlex
- W1512900561
- Cited by
- 205
- References
- 45
- Citations by year
- 2026: 6 · 2025: 4 · 2024: 3 · 2023: 6 · 2022: 2 · 2021: 7 · 2020: 2 · 2019: 9 · 2018: 4 · 2017: 14 · 2016: 6 · 2015: 6 · 2014: 9 · 2013: 11 · 2012: 15
- FWCI
- 0.64
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Journal of Clinical Immunology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5p01ag014669-03)
- National Institute on Aging (AG-14669)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Immunodeficiency and Autoimmune Disorders
- Health Sciences › Medicine › Pathology and Forensic Medicine › Lymphoma Diagnosis and Treatment
- Keywords
- B cell receptor repertoire, aging, naive B cells, bone marrow, germinal center, affinity maturation, class switch recombination, lymphopenia, B cell clonal expansion, M protein, B-cell malignancies, antibody diversity
- MeSH terms
- Adjuvants, Immunologic, Aged, Aging, Animals, Antibodies, Anti-Idiotypic, Antibody Formation, Antigens, Bacterial, Autoantibodies, Bone Marrow, Cell Division, Clone Cells, Disease Susceptibility, Hematopoiesis, Humans, Lymphopenia, Lymphoproliferative Disorders, Gene Rearrangement, B-Lymphocyte, Autoimmunity, B-Lymphocyte Subsets, Mice, SCID, Lymphocyte Count, Germinal Center, Mice
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