Cited by 206T-cell and B-cell ImmunologyImmunodeficiency and Autoimmune DisordersLymphoma Diagnosis and Treatment

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The Effect of Age on the B-Cell Repertoire

Weksler, Marc E., Szabo, Paul·2000·Journal of Clinical Immunology

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Abstract

The antibody repertoire changes with age. This change reflects, in part, the age-associated impairment in the production of a diverse population of naive B cells in the bone marrow and, in part, by the decreased diversification of B cells in the germinal center where affinity maturation and isotype switching takes place. B cell number is strictly regulated and despite the decreased output of B cells by the bone marrow does not decline during aging. Self-renewal of peripheral B cells is sufficient to assure the stability of peripheral B cell number. However, when B cell production is stressed as, for example, following drug-induced lymphopenia, the rate of recovery of B cell number as well as of B cell diversity is compromised in old compared to young mice. Finally, aging is associated with the appearance of B cell clonal expansions which not only limit the diversity of the B cell repertoire but very likely give rise to monoclonal serum immunoglobulins and B cell neoplasms.

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Authors: Weksler, M. E., & Szabo, P.
Affiliations: Cornell University (US)
Venue: Journal of Clinical Immunology
Publisher: Springer Science and Business Media LLC
Published: 2000-07
Volume: 20
Issue: 4
Pages: 240-249
ISSN: 0271-9142 (ISSN-L)
1573-2592
DOI: 10.1023/a:1006659401385
OpenAlex: W1512900561
Cited by: 205
References: 45
Citations by year: 2026: 6 · 2025: 4 · 2024: 3 · 2023: 6 · 2022: 2 · 2021: 7 · 2020: 2 · 2019: 9 · 2018: 4 · 2017: 14 · 2016: 6 · 2015: 6 · 2014: 9 · 2013: 11 · 2012: 15
FWCI: 0.64
Type: journal article
Language: en
Open access: closed
Licence: www.springernature.com/gp/researchers/text-and-data-mining (tdm)
www.springernature.com/gp/researchers/text-and-data-mining (vor)
Locations: Journal of Clinical Immunology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5p01ag014669-03)
National Institute on Aging (AG-14669)
Topics: Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Immunology and Microbiology › Immunology › Immunodeficiency and Autoimmune Disorders
Health Sciences › Medicine › Pathology and Forensic Medicine › Lymphoma Diagnosis and Treatment
Keywords: B cell receptor repertoire, aging, naive B cells, bone marrow, germinal center, affinity maturation, class switch recombination, lymphopenia, B cell clonal expansion, M protein, B-cell malignancies, antibody diversity
MeSH terms: Adjuvants, Immunologic, Aged, Aging, Animals, Antibodies, Anti-Idiotypic, Antibody Formation, Antigens, Bacterial, Autoantibodies, Bone Marrow, Cell Division, Clone Cells, Disease Susceptibility, Hematopoiesis, Humans, Lymphopenia, Lymphoproliferative Disorders, Gene Rearrangement, B-Lymphocyte, Autoimmunity, B-Lymphocyte Subsets, Mice, SCID, Lymphocyte Count, Germinal Center, Mice

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The Effect of Age on the B-Cell Repertoire

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