The DOI matches its Crossref record; 11 of the 12 references it cites were found in a registry or an index.
Isolation of a petite mutant from a histidine auxotroph of Candida albicans and its characterization
Abstract
Respiration-deficient (petite) mutations have been induced in various yeasts, which are categorized as petite-positive. Candida albicans was classified among the petite-negative yeasts. Since then, a few reports have appeared, describing the isolation of petite mutants in C. albicans. We report in the present study on the isolation of a petite mutant of C. albicans-SAR1. This mutant was isolated from a histidine auxotroph of C. albicans after mutagenesis with N-methyl-N'-nitro-N-nitrosoguanidine, thus our petite mutant carries a double mutation. SAR1 was characterized morphologically, biochemically and ultrastructurally. The results revealed differences from the wild type in respect to morphological, physiological and biochemical characteristics. Electron microscopy showed that the cells of the petite mutant contain only very few mitochondria that looked 'thread like' without any cristae. The significance of the mutation in the virulence of the mutant vs. that of the wild-type is being assessed.
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“Other C. albicans petite strains have been described, but most are induced by harsh chemical treatments, and therefore, correlations of specific mitochondrial dysfunctions with azole resistance are more difficult to interpret (15–17).”
From Azole Susceptibility and Transcriptome Profiling in Candida albicans Mitochondrial Electron Transport Chain Complex I Mutants (2013) · cites this paper as [17]
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Cites
Sherman, F., Fink, G. R., & Hicks, J. B. (1979) · Cold Spring Harbor Laboratory eBooks · Cited by 7,430
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Induction of petite mutation and inhibition of synthesis of respiratory enzymes in various yeasts
Bulder, C. J. E. A. (1964) · Antonie van Leeuwenhoek · doi:10.1007/bf02046695 · Cited by 162
ADVANCES IN THE STUDY OF RESPIRATION-DEFICIENT (RD) MUTATION IN YEAST AND OTHER MICROORGANISMS
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Ferguson, L. R., & von Borstel, R. C. (1992) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/0027-5107(92)90042-z · Cited by 93
Lethality of the petite mutation in petite negative yeasts
Bulder, C. J. E. A. (1964) · Antonie van Leeuwenhoek · doi:10.1007/bf02046758 · Cited by 92
DIAGNOSTIC COLOR DIFFERENTIATION PLATES FOR HEREDITARY RESPIRATION DEFICIENCY IN YEAST
Nagai, S. (1963) · Journal of Bacteriology · doi:10.1128/jb.86.2.299-302.1963 · Cited by 50
Induction of petite mutation with acriflavine and elevated temperature inCandida albicans
Aoki, S., & Ito‐Kuwa, S. (1987) · Medical Mycology · doi:10.1080/02681218780000611 · Cited by 36
Selection and characterization of acriflavine-induced mutants of Candida albicans
Watkins, P. D., Brandt, P. M., & McClary, D. O. (1974) · Antonie van Leeuwenhoek · doi:10.1007/bf00394562 · Cited by 20
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The helicase CaHmi1p is required for wild-type mitochondrial DNA organization in Candida albicans
Jõers, P., Gerhold, J. M., Sedman, T., Kuusk, S., & Sedman, J. (2006) · FEMS Yeast Research · doi:10.1111/j.1567-1364.2006.00132.x · Cited by 15
Antifungal Targets, Mechanisms of Action, and Resistance in Candida albicans
Akins, R. A., & Sobel, J. D. (2009) · Humana Press eBooks · doi:10.1007/978-1-59745-180-2_29 · Cited by 12
Sigi mon amour, ci-gît l'amour
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Metadata
- Authors
- Roth-Ben Arie, Z., Altboum, Z., Berdicevsky, I., & Segal, E.
- Affiliations
- Israel Institute for Biological Research (IL)
- Technion – Israel Institute of Technology (IL)
- Tel Aviv University (IL)
- ORCID
- Segal, E.
- Venue
- Mycopathologia
- Published
- 1998-03
- Volume
- 141
- Issue
- 3
- Pages
- 127-135
- ISSN
- 0301-486X (ISSN-L)
- 1573-0832
- OpenAlex
- W1515397945
- Cited by
- 11
- References
- 12
- Citations by year
- 2012: 1
- FWCI
- 0.47
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Mycopathologia (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Keywords
- petite mutants, Candida albicans, histidine auxotrophs, N-methyl-N'-nitro-N-nitrosoguanidine mutagenesis, double mutations, mitochondrial ultrastructure, mitochondrial cristae, yeast morphology, yeast physiology, virulence
- MeSH terms
- Candida albicans, Cloning, Molecular, Methylnitronitrosoguanidine, Microscopy, Electron, Mutagens, Mycology, Mutagenesis
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